Resumo
Objetivo: Discutir o atual conhecimento acerca das complicações e desfechos cardiovasculares desencadeados pela COVID-19 na UTI. Métodos: Para a revisão integrativa, utilizou-se a busca avançada de estudos observacionais e intervencionais, quantitativos e qualitativos, nas plataformas PubMed e VHL, com os seguintes Descritores em Ciências da Saúde (DeCS) em inglês: “Cardiovascular”, “COVID-19”, “Complications” e “Intensive Care Units”, intercalados pelo operador booleano AND. Os trabalhos de 2019 a 2023, gratuitos e em inglês e/ou português foram incluídos, e aqueles que desviaram da pergunta norteadora, excluídos. Resultados: Dos 180 artigos encontrados, 15 satisfizeram os critérios definidos. Observou-se alta prevalência de eventos tromboembólicos, lesões miocárdicas e vasculares em milhares de pacientes com COVID-19 na UTI, com relação direta entre a alteração de marcadores de doença cardiovascular em COVID-19 e maus prognósticos, além de um “efeito cascata” para novas complicações a cada evento. Considerações finais: Com o exposto impacto cardiovascular da COVID-19 em pacientes de UTI, faz-se necessária a adoção de medidas profiláticas baseadas em evidências, a partir de estudos epidemiológicos para maior esclarecimento das ocorrências desses eventos, seguidos de novas coortes prospectivas e ensaios clínicos, para avaliar continuamente esses indivíduos e as intervenções feitas.
Referências
BARDAJÍ A, et al. Prognostic implications of myocardial injury in patients with and without COVID-19 infection treated in a university hospital. Revista española de Cardiologia. 2021; 74(1): 24-32.
BERG DD, et al. Epidemiology of Acute Heart Failure in Critically Ill Patients With COVID-19: An Analysis From the Critical Care Cardiology Trials Network. Journal of cardiac failure. 2022; 28(4): 675-681.
BILALOGLU S, et al. Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System. JAMA. 2020; 324(8): 799-801.
CHUNG MK, et al. COVID-19 and Cardiovascular Disease: From Bench to Bedside. Circ Res. 2021; 128(8): 1214-1236.
CUCINOTTA D E VANELLI M. WHO Declares COVID-19 a Pandemic. Acta Biomédica. 2020; 91(1): 157-160.
GOSHUA G, et al. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol. 2020; 7(8): 575-582.
GOMES BFO, et al. Impacto do Alto Risco Cardiovascular na Mortalidade Hospitalar em Pacientes Internados em Terapia Intensiva por COVID-19. Arquivos brasileiros de cardiologia. 2022; 118(5): 927-934.
HAMEED M, et al. Factors influencing international collaboration on the prevention of COVID-19. Elsevier Public Health Emergency Collection. 2022; 212: 95-101.
HAYEK SS, et al. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. British Medical Journal. 2020; 371: e3513.
HOFFMANN M, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020; 181(2): 271-280.
HUANG C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Elsevier Public Health Emergency Collection. 2020; 395 (10223): 497-506.
IMIG JD. SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection. Clin Sci (Lond). 2022; 136(6): 431-434.
JAIN, V, YUAN JM. Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis. Nature Public Health Emergency Collection. 2020; 65(5): 533-546.
JOHN HOPKINS UNIVERSITY. 2023. In: COVID-19 Map. Baltimore: Coronavirus Resource Center. Disponível em: http://bit.ly/3ZXllNb. Acesso em: 15 jul. 2023.
LA VIA L, et al. Full and simplified assessment of left ventricular diastolic function in covid-19 patients admitted to ICU: Feasibility, incidence, and association with mortality. Echocardiography. 2022; 39(11): 1391-1400.
McCALL PJ, et al. Right ventricular dysfunction in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a multicentre prospective cohort study. Anaesthesia. 2022; 77(7): 772-784.
MEDATALIBEYOGLU A, et al. Cardiovascular view of intermediate and high-risk COVID-19 patients: single-centre experience with low mortality and intensive care hospitalization rates. Cardiovascular Journal of Africa. 2020; 32(2): 79-86.
PARASHER A. COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment. BMJ Journals. 2021; 97(1147): 312-320.
PATEL U, et al. Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association. 2021; 30(7): e105805.
POUW, N. et al. Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study. Plo S one. 2021; 16(3): e248713.
QIAN H, et al. Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: A Retrospective in-ICU Study. J Cardiothorac Vasc Anesth. 2021; 35(3): 846-853.
RELLO J, et al. Update in COVID-2019 in the intensive care unit from the 2020 HELLENIC Athens International symposium. Elsevier Public Health Emergency Collection. 2020; 39(6): 723-730.
SLUIS WM, et al. Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19: A Multicenter Cohort Study. Stroke. 2021; 52(12): 3978-3986.
SULEMANE S, et al. Acute pulmonary embolism in conjunction with intramural right ventricular thrombus in a SARS-CoV-2-positive patient. European Heart Journal. 2020; 115.
VASBINDER A, et al. Relationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19. Circulation: Cardiovascular quality and outcomes. 2020; 15(10): e8942.
