Palavras-chave
Perfil imunohematológico
Marcadores informativos de ancestralidade
População miscigenada
Como Citar
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Resumo
Objetivo: Avaliar os perfis hematológicos e linfocitários de indivíduos com COVID-19, bem como, identificar o perfil ancestral por meio de Marcadores Informativos de Ancestralidade de duas cidades da região Nordeste do Brasil. Métodos: Foram analisados os dados de 58 indivíduos com COVID-19 que apresentavam condições clínicas leves (39) e graves (19). O perfil linfocitário foi identificado por imunofenotipagem e genotipagem via análise de PCR e qPCR. Os dados foram analisados por estatística descritiva usando o software IBM SPSS Statistics. O estudo foi aprovado pelo Comitê de Ética em Pesquisa (ICS-UFBA). Resultados: Os indivíduos do grupo grave apresentaram aumento de leucócitos totais e neutrófilos, diminuição de eritrócitos, hemoglobina, hematócrito e de linfócitos em comparação aos indivíduos do grupo leve. Assim como, o grupo grave apresentou diminuição nos perfis celulares de células TCD4+, TCD8+ e linfócitos B. Em relação ao perfil ancestral, ambos os grupos apresentaram maior perfil genômico ancestral europeu. No entanto, o grupo grave apresentou maior percentual de ancestralidade africana em comparação ao grupo leve. Conclusão: A ancestralidade não foi associada à gravidade, mas os resultados correspondem às descobertas de que as respostas imunes dos indivíduos desempenha um papel crucial na COVID-19.
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