Palavras-chave
Terapia com Luz de Baixa Intensidade
Síndrome de Down
Leucemia Linfoide
Como Citar
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Resumo
Objetivo: Relatar o caso clínico com uso da Fotobiomodulação (FBM) no tratamento de mucosite oral (MO) em uma paciente de 15 anos, com síndrome de Down (SD) e leucemia linfóide aguda (LLA), diagnosticada com LLA, o tratamento realizado e conclusão do caso. Detalhamento do Caso: Paciente branca, sexo feminino, 15 anos, diagnosticada com LLA e em tratamento quimioterápico com metotrexato em altas doses, desenvolveu MO, manifestando lesões orais dolorosas que dificultavam a alimentação. Como tratamento iniciou-se a terapia com FBM, ajustando a abordagem conforme a colaboração variável da paciente. Após algumas sessões, observou-se uma melhora significativa na cicatrização das lesões e na redução da dor, permitindo a retomada da alimentação oral sem desconforto significativo. Considerações Finais: A experiência clínica observada neste estudo sublinha a relevância e importância de se utilizar a FBM como uma intervenção valiosa para o manejo da MO em pacientes vulneráveis, incluindo também pacientes com SD e em tratamento quimioterápico.
Referências
AL-ANSARI S, et al. Oral mucositis induced by anticancer therapies. Current oral health reports, 2015; 2: 202-211.
AMADORI F, et al. Low-level laser therapy for treatment of chemotherapy-induced oral mucositis in childhood: a randomized double-blind controlled study. Lasers in medical science, 2016; 31: 1231-1236.
AMARO JS, et al. Fotobiomodulação como tratamento auxiliar de mucosite oral em pacientes submetidos a tratamentos antineoplásicos: revisão integrativa. Research, Society and Development, 2022; 11(8): e15511830827.
BASSO FG, et al. Biomodulation of inflammatory cytokines related to oral mucositis by low‐level laser therapy. Photochemistry and photobiology, 2015; 91(4): 952-956.
CHIANG JC, et al. Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro. Nature communications, 2018; 9(1): 5180.
CHUNG H, et al. The nuts and bolts of low-level laser (light) therapy. Annals of biomedical engineering, 2012; 40: 516-533.
CRUZ LB, et al. Influence of low‐energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy. Pediatric blood & cancer, 2007; 48(4): 435-440.
DE CASTRO JFL, et al. Low-level laser in prevention and treatment of oral mucositis in pediatric patients with acute lymphoblastic leukemia. Photomedicine and Laser surgery, 2013; 31(12): 613-618.
GOBBO M, et al. Multicenter randomized, double‐blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Pediatric blood & cancer, 2018; 65(8): e27098.
KUHN A, et al. Low-level infrared laser therapy in chemotherapy-induced oral mucositis: a randomized placebo-controlled trial in children. Journal of pediatric hematology/oncology, 2009; 31(1): 33-37.
LAURENT AP, KOTECHA RS, MALINGE S. Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome. Leukemia, 2020; 34(8): 1984-1999.
LIAO W, LIU Y. Treatment outcomes in children with Acute lymphoblastic leukemia with versus without coexisting Down's syndrome: a systematic review and meta-analysis. Medicine, 2020; 99(29): e21015.
MAZHARI F, SHIRAZI AS, SHABZENDEHDAR M. Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta‐analysis. Pediatric Blood & Cancer, 2019; 66(3): e27403.
MURPHY BR, et al. Development of acute lymphoblastic leukemia following treatment for acute myeloid leukemia in children with Down syndrome: A case report and retrospective review of Children's Oncology Group acute myeloid leukemia trials. Pediatric blood & cancer, 2019; 66(8): e27700.
PERALTA-MAMANI M, et al. Low-level laser therapy dosimetry most used for oral mucositis due to radiotherapy for head and neck cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 2019; 138: 14-23.
REDMAN MG, HARRIS K, PHILLIPS BS. Low-level laser therapy for oral mucositis in children with cancer. Archives of Disease in Childhood, 2022; 107(2): 128-133.
REYAD FA, ELSAYED NM, EL CHAZLI Y. Photobiomodulation for chemotherapy‐induced oral mucositis in leukemic children: A randomized controlled clinical trial. Oral diseases, 2023; 29(5): 2239-2247.
REZK-ALLAH SS, et al. Effect of low-level laser therapy in treatment of chemotherapy induced oral mucositis. Journal of lasers in medical sciences, 2019; 10(2): 125.
ROBERTS KG. Genetics and prognosis of ALL in children vs adults. Hematology 2014, The American Society of Hematology Education Program Book, 2018; 2018(1): 137-145.
SONIS ST, et al. Perspectives on cancer therapy‐induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer: Interdisciplinary International Journal of the American Cancer Society, 2004; 100(S9): 1995-2025.
SUNG L, et al. Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ supportive & palliative care, 2017; 7(1): 7-16.
ZIPURSKY A. Susceptibility to leukemia and resistance to solid tumors in Down syndrome. Pediatric research, 2000; 47(6): 704.