Palavras-chave
Desenvolvimento de medicamentos
Aplicação terapêutica
Como Citar
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Resumo
Objetivo: Sintetizar evidências científicas visando apontar a relevância dos compostos heterocíclicos à química medicinal e saúde humana. Revisão Bibliográfica: Os compostos heterocíclicos são caracterizados pela presença de anel fechado contendo um ou mais átomos diferentes de carbono. Esses compostos têm ganhado significativa atenção devido à grande versatilidade de uso no contexto da saúde. Diversas biomoléculas naturais ou sintéticas são constituídas por anéis heterocíclicos, tais como a molécula de DNA, o ATP, antibióticos utilizados em infecções de importância clínica, a cafeína, anticoagulantes como a varfarina e diversos outros compostos capazes de curar ou melhorar a qualidade de vida dos seres humanos. O interesse da pesquisa relacionada a esses compostos está aumentando rapidamente, devido aos avanços em metodologias sintéticas e a sua versatilidade na interação com alvos biológicos. Na presente revisão, relata-se os recentes avanços de derivados heterocíclicos, como os derivados de piridina, tiofeno, pirrol, cumarinas, furano, quinolina e outros, no desenvolvimento de anti-inflamatórios, anticancerígenos, antibióticos, antifúngicos e outros. Considerações Finais: A pesquisa contínua relacionada à síntese de novas substâncias derivadas de compostos heterocíclicos é essencial para redução da morbi-mortalidade de diversas doenças que afligem a sociedade.
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