Palavras-chave
Tiossemicarbazonas
Quimioterapia
Protozoários
Leishmania infantum
Como Citar
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Resumo
Objetivo: Reunir as principais informações disponíveis na literatura sobre os avanços, limitações e perspectivas do uso das tiossemicarbazonas como agente leishmanicida à Leishmania infantum, causador da Leishmaniose Visceral, abordando suas propriedades químicas, mecanismos de ação, resultados de estudos in vitro. Revisão bibliográfica: A leishmaniose visceral (LV) é uma doença tropical negligenciada de alta morbidade e mortalidade, cujo tratamento convencional inclui fármacos como antimoniais pentavalentes, anfotericina B, miltefosina, pentamidina e paromomicina. Apesar de sua eficácia, essas terapias apresentam importantes limitações, como toxicidade sistêmica, alto custo, dificuldades na administração e surgimento de cepas resistentes. Diante desse cenário, as tiossemicarbazonas (TSCs) têm sido investigadas como alternativas promissoras. Trata-se de compostos orgânicos versáteis, com capacidade de modificação estrutural que favorece a atividade antiparasitária e reduz efeitos adversos. Estudos relatam diversos mecanismos de ação, incluindo despolarização mitocondrial, interação com o DNA parasitário, indução de apoptose e inibição de proteínas essenciais. Ensaios in vitro demonstram que derivados de TSCs apresentam atividade leishmanicida significativa, inclusive contra cepas resistentes à terapia convencional. Considerações finais: Segundo a literatura, as tiossemicarbazonas representam uma alternativa promissora para o desenvolvimento de novos tratamentos contra a LV, destacando-se como foco relevante para pesquisas futuras.
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