Palavras-chave
Terapia de reposição hormonal
Menopausa
Revisão
Como Citar
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Resumo
Objetivo: Avaliar os riscos e benefícios relacionados à terapia de reposição hormonal (TRH) na menopausa. Métodos: Trata-se de uma revisão integrativa de literatura, cuja pergunta norteadora foi: “Quais os riscos e quais os benefícios da utilização de TRH em pacientes na menopausa?”. Para respondê-la, foram realizadas buscas nas plataformas Pubmed, Lilacs e Scielo, com os descritores correspondentes a “Terapia de Reposição Hormonal” e “Menopausa”. Foram incluídos artigos dos últimos 5 anos disponíveis na íntegra sem restrição de idiomas e pertinentes ao tema. Resultados: Foram selecionados 22 estudos para análise dos riscos e benefícios da TRH. Conclusão: A TRH apresentou benefícios sobre a saúde cardiovascular, redução do LDL, densidade mineral óssea e de marcadores inflamatórios, melhoras de sintomas vasomotores e geniturinários, cognição e sono, musculatura do assoalho pélvico e hipoatividade sexual em mulheres na menopausa. Foram apontados malefícios sobre o risco de DAC, demência, tumores do SNC e alterações na função de coagulação, dualidade que pode ser explicada pelo esquema de TRH instituído, bem como pelo momento de início da TRH. Com relação ao câncer de mama, os riscos e benefícios não puderam ser completamente elucidados, já que a modalidade de TRH utilizada parece influenciar os desfechos.
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