Palavras-chave
Mucosite bucal
Neoplasias
Como Citar
Copyright © | Todos os direitos reservados.
A revista detém os direitos autorais exclusivos de publicação deste artigo nos termos da lei 9610/98.
Reprodução parcial
É livre o uso de partes do texto, figuras e questionário do artigo, sendo obrigatória a citação dos autores e revista.
Reprodução total
É expressamente proibida, devendo ser autorizada pela revista.
Resumo
Objetivo: Investigar se a apiterapia é eficaz no tratamento da mucosite oral em pacientes com câncer.
Métodos: Foram realizadas buscas nas seguintes bases de dados até julho de 2024: PubMed/MEDLINE, Scopus, Embase, Web of Science, Cochrane Library, SciELO e Lilacs. As estatísticas Q de Cochrane e I² de Higgins foram utilizadas para detectar heterogeneidade, enquanto o teste de Mantel-Haenszel foi empregado para a síntese dos dados por meio do software RStudio. O risco de viés foi avaliado utilizando a ferramenta Cochrane Riisk of Bias 2. Resultados: Após a busca inicial, foram identificados 857 artigos. Aplicando-se os critérios de elegibilidade, 18 ensaios clínicos randomizados foram incluídos nesta revisão, sendo 11 sobre o mel e 7 sobre o própolis, com baixo risco de viés em três dos estudos com mel e própolis. Os resultados da presente metanálise não demonstraram diferenças estatisticamente significativas para nenhum dos agentes no tratamento e/ou prevenção da mucosite oral (P > 0,05). Além disso, foi observada alta heterogeneidade (I² > 65%) nos grupos tratados com mel para mucosite leve, moderada e grave. Considerações finais: Mel e própolis não se mostraram eficazes para o tratamento ou prevenção da mucosite oral; no entanto, esses resultados devem ser interpretados com cautela, dado que alguns estudos apresentaram alta heterogeneidade.
Referências
AKHAVANKARBASSI MH, et al. Randomized double-blind placebo-controlled trial of propolis for oral mucositis in patients receiving chemotherapy for head and neck cancer. Asian Pacific Journal of Cancer Prevention, 2016; 17(7): 3611-3614.
ALLAIRE J. RStudio: integrated development environment for R. Boston, MA, 2012; 770(394): 165-171.
BADR LK, et al. The efficacy of honey or olive oil on the severity of oral mucositis and pain compared to placebo in children with leukemia. Journal of Pediatric Nursing, 2023; 70: e48-e53.
BOLOURI AJ, et al. Preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers: a triple-blind, randomized, placebo-controlled trial. Iranian Journal of Cancer Prevention, 2015; 8(5).
BOWDEN J, et al. Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Medical Research Methodology, 2011; 11(1): 1-12.
BROWN TJ, GUPTA A. Management of cancer therapy–associated oral mucositis. JCO Oncology Practice, 2020; 16(3): 103-109.
CHARALAMBOUS M, et al. The effect of the use of thyme honey in minimizing radiation-induced oral mucositis in head and neck cancer patients: a randomized controlled trial. European Journal of Oncology Nursing, 2018; 34: 89-97.
CO JL, et al. Effectiveness of honey on radiation-induced oral mucositis: a meta-analysis and systematic review. Head and Neck, 2016; 38(7): 1119-1128.
DASTAN F, et al. Efficacy and safety of propolis mouthwash in management of radiotherapy induced oral mucositis: a randomized, double blind clinical trial. Reports of Practical Oncology & Radiotherapy, 2020; 25(6): 969-973.
DAUGĖLAITĖ G, et al. Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis. Medicina, 2019; 55(2): 25.
FERNANDES PM, et al. Brazilian organic propolis for prevention and treatment of radiation-related oral acute toxicities in head and neck cancer patients: a double-blind randomized clinical trial. Frontiers in Pharmacology, 2022; 13: 973255.
HAMZAH MH, et al. Propolis mouthwash for preventing radiotherapy-induced mucositis in patients with nasopharyngeal carcinoma. Medical Journal of Malaysia, 2022; 77(4): 462-467.
HAO S, et al. Effect of honey on pediatric radio/chemotherapy-induced oral mucositis: a systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine, 2022; 2022: 6906439.
HAWLEY P, et al. A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Supportive Care in Cancer, 2014; 22: 751-761.
HIGGINS JPT, et al. Assessing risk of bias in a randomized trial. Cochrane Handbook for Systematic Reviews of Interventions, 2021; Chapter 8.
JAHANBANI MAZRAEH E, et al. Assessment of thyme honey oral gel for prevention of chemotherapy-induced oral mucositis in breast cancer patients. Supportive Care in Cancer, 2023; 31(8): 497.
JAYACHANDRAN S, BALAJI N. Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian Journal of Palliative Care, 2012; 18(3): 190.
KHANAL B, et al. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. International Journal of Oral and Maxillofacial Surgery, 2010; 39(12): 1181-1185.
KHANJANI POUR-FARD-PACHEKENARI A, et al. The effect of an oral care protocol and honey mouthwash on mucositis in acute myeloid leukemia patients: a single-blind clinical trial. Clinical Oral Investigations, 2019; 23: 1811-1821.
LALLA RV, et al. Management of oral mucositis in patients who have cancer. Dental Clinics of North America, 2008; 52(1): 61-77.
LIMA ICGDS, et al. Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis. Clinical Oral Investigations, 2021; 25(6): 4115-4124.
MOTALLEBNEJAD M, et al. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract, 2008; 9(3): 40-47.
MÜNSTEDT K, et al. Honey in the management of side effects of radiotherapy-induced oral mucositis: a systematic review. Complementary Therapies in Clinical Practice, 2019; 34: 145-152.
MÜNSTEDT K, MÄNNLE H. Using bee products for the prevention and treatment of oral mucositis induced by cancer treatment. Molecules, 2019; 24(17): 3023.
NONZEE NJ, et al. Evaluating the supportive care costs of severe radiochemotherapy‐induced mucositis and pharyngitis. Cancer, 2008; 113(6): 1446-1452.
PAGE MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. International Journal of Surgery, 2021; 88: 105906.
PATIL K, et al. Effectiveness of topical application of honey in the management of radiation induced oral mucositis. Journal of Indian Academy of Oral Medicine and Radiology, 2022; 34(2): 141-145.
PATIL K, et al. Natural honey as an effective adjunct in the management of radiation induced oral mucositis. Indian Journal of Forensic Medicine & Toxicology, 2021; 15(2): 3698-3706.
SALEHI M, et al. The effect of propolis tablet on oral mucositis caused by chemotherapy. Gazi Medical Journal, 2018; 29(3).
SENER DK, et al. The effect of oral care with chlorhexidine, vitamin E and honey on mucositis in pediatric intensive care patients: a randomized controlled trial. Journal of Pediatric Nursing, 2019; 45: e95-e101.
TIAN X, et al. Impact of honey on radiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis. Annals of Palliative Medicine, 2020; 9(4): 1431-1441.
TOMAŽEVIČ T, JAZBEC J. A double blind randomised placebo controlled study of propolis effectiveness in the treatment of severe oral mucositis in chemotherapy treated children. Complementary Therapies in Medicine, 2013; 21(4): 306-312.
UĞUR Ö, et al. The effect of honey therapy on the management of oral mucositis in head and neck cancer patients with chemoradiotherapy: a randomized controlled study. Journal of Basic and Clinical Health Sciences, 2023; 7: 589-600.
WEHBE R, et al. Bee venom: Overview of main compounds and bioactivities for therapeutic interests. Molecules, 2019; 24(16): 2997.
YANG C, et al. Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: a systematic review and network meta-analysis. International Journal of Nursing Studies, 2019; 89: 80-87.