Palavras-chave
Imunoterapia
Câncer
Como Citar
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Resumo
Objetivo: Mapear as evidências disponíveis sobre a relação entre a doença periodontal e a resposta à imunoterapia em pacientes oncológicos. Revisão bibliográfica: A inflamação periodontal pode modular a resposta imunológica e interferir na eficácia da imunoterapia, tanto pelo aumento da inflamação sistêmica quanto pela alteração do microbioma oral. Patógenos periodontais, como Porphyromonas gingivalis e Fusobacterium nucleatum, têm sido implicados na modulação de vias oncogênicas e imunológicas, contribuindo para a progressão tumoral e para a ocorrência de efeitos adversos durante o tratamento. Estudos recentes reforçam a existência de uma interação bidirecional entre a saúde periodontal e as respostas terapêuticas oncológicas, sugerindo que o controle da inflamação bucal pode impactar positivamente os desfechos clínicos de pacientes submetidos à imunoterapia. Considerações finais: A saúde periodontal pode desempenhar um papel relevante no manejo oncológico de pacientes submetidos à imunoterapia. Apesar das evidências iniciais, ainda não há consenso sobre protocolos específicos, sendo necessários estudos clínicos prospectivos e multicêntricos para validar essa associação e orientar estratégias preventivas e terapêuticas integradas.
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