Palavras-chave
Sistema imune
Inibidor de tirosina quinase
Suspensão de tratamento
Como Citar
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Resumo
Objetivo: Realizar análise e revisão dos principais artigos disponíveis sobre a influência do sistema imune no sucesso da descontinuação dos inibidores de tirosina quinase na leucemia mieloide crônica. Revisão bibliográfica: O conceito recente de remissão livre de tratamento (RLT) surge como um alvo atrativo, permitindo que pacientes com diagnóstico de leucemia mieloide crônica com respostas moleculares profundas possam descontinuar o tratamento com os inibidores de tirosina quinase (ITQ). O sistema imunológico desempenha um papel fundamental no sucesso da descontinuação dos ITQ. Células natural killers (NK) e células T CD8+ efetoras são essenciais para a vigilância imunológica e controle da doença. Além disso, a presença de células T citotóxicas específicas está associada a uma remissão sustentada. Adicionalmente, o tratamento com ITQ reduz a carga leucêmica, permitindo a reativação das respostas imunes efetivas e a eliminação de células tumorais. Considerações finais: Nesse contexto, há uma necessidade de novas abordagens terapêuticas que reforcem a resposta imunológica e explorem combinações de ITQ com agentes imunoestimuladores, visando otimizar a manutenção da remissão e proporcionar uma terapia mais eficaz e que melhore a qualidade de vida.
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