Palavras-chave
Selênio
Suplementos Dietéticos
Genômica
Como Citar
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Resumo
Objetivo: Nosso objetivo foi elucidar, por meio de revisão sistemática e meta-análise, como a exposição ao selênio pode influenciar a ativação da via de sinalização PI3K/Akt/GLUT-4 em modelos animais de diabetes. Métodos: A busca foi realizada nas bases de dados PubMed/Medline, Cochrane Library, LILACS, Web of Science e Scopus, sem limite temporal, com foco em estudos conduzidos em modelos animais de diabetes. Resultados: Treze artigos foram incluídos nesta revisão. Os resultados mostram que a suplementação com selênio resultou em aumento da expressão da proteína GLUT-4, bem como melhora da glicemia de jejum, insulinemia de jejum e HOMA-IR em modelos animais, contrariando estudos conduzidos em humanos que demonstram um efeito diabetogênico desse mineral em muitos estudos realizados. Da mesma forma, esta meta-análise mostra resultados controversos em relação à modulação da via PI3K/Akt/GLUT-4 e ao metabolismo da glicose em diferentes modelos animais. Considerações finais: A relação entre o selênio e a sinalização da insulina é complexa e depende da dose, do composto e do tecido; é importante interpretar esses resultados com cautela.
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