Resumo
Objetivo: Relatar o caso de paciente com lúpus eritematoso sistêmico (LES) que apresentou hemorragia alveolar difusa de evolução subaguda, evidenciando uma forma incomum de apresentação clínica. Detalhamento do caso: Paciente do sexo feminino, 17 anos, portadora de LES, apresentou quadro respiratório subagudo com evolução de três meses, manifestado por dispneia, febre, dor torácica e alguns episódios de hemoptise. Na admissão, encontrava-se hemodinamicamente estável e eupneica. Exames demonstraram anemia, elevação de provas inflamatórias e consumo de complemento, sem disfunção renal, associado a extensas opacidades em vidro fosco difusas e bilaterais e grave acometimento pulmonar. Após exclusão de diagnósticos diferenciais, estabeleceu-se o diagnóstico de hemorragia alveolar difusa (HAD) associada ao LES. Recebeu pulsoterapia com corticoide e ciclofosfamida, com evolução favorável, sem necessidade de ventilação mecânica e de cuidados críticos. Considerações finais: a HAD subaguda é rara, principalmente quando associada ao LES, reforçando a importância da suspeição diagnóstica em pacientes lúpicos. O manejo oportuno foi determinante para o desfecho favorável.
Referências
AL-ADHOUBI NK, BYSTROM J. Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies. Lupus, 2020; 29(4): 355-363.
ARAUJO DB, et al. Alveolar hemorrhage: distinct features of juvenile and adult onset systemic lupus erythematosus. Lupus, 2012; 21(8): 872-877.
BARBER MRW, et al. Global epidemiology of systemic lupus erythematosus. Nature Reviews Rheumatology, 2021; 17(9): 515-532.
COJOCARU M, et al. Manifestations of systemic lupus erythematosus. Maedica, 2011; 6(4): 330.
DZIEDZIC R, et al. Characteristics of systemic lupus erythematosus patients with diffuse alveolar hemorrhage: clinical features and outcomes from a single-center experience. Journal of Clinical Medicine, 2025; 14(16): 5614.
FREIRE EAM, et al. Medidas de avaliação em lúpus eritematoso sistêmico. Revista Brasileira de Reumatologia, 2011; 51: 75-80.
GARCIA-VILLANUEVA MJ, et al. Diffuse alveolar hemorrhage in patients with systemic lupus erythematosus: data from the Spanish society of rheumathology Lupus Register (RELESSER). Rheumatology International, 2024; 44(11): 2445-2455.
HANNAH JR, D’CRUZ DP. Pulmonary complications of systemic lupus erythematosus. Seminars in Respiratory and Critical Care Medicine, 2019; 40(2): 227-234.
HUO R, et al. Systemic lupus erythematosus with diffuse alveolar hemorrhage. Chinese Medical Journal, 2023; 136(23): 2883-2885.
JAMSHEER F, et al. Diffuse alveolar hemorrhage as a life-threatening complication of systemic lupus erythematosus: a case report. Cureus, 2024; 16(11): e73586.
JAROLIN DM, SOBARZO P. Hemorragia alveolar como forma de debut de lupus eritematoso sistémico. Revista Paraguaya de Reumatología, 2019; 5(1): 27-32.
JIANG M, et al. Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis. Arthritis Research & Therapy, 2021; 23(1): 57.
LATER S, et al. Diffuse Alveolar Hemorrhage as the First Presentation of Systemic Lupus Erythematosus: A Case Report. The American Journal of Case Reports, 2025; 26: e947096.
LAW AH, et al. Diffuse alveolar haemorrhage in systemic lupus erythematosus: A multicentre retrospective study in Singapore. Lupus, 2023; 32(8): 952-963.
LUNDGREN MC, et al. A fatal case of diffuse alveolar hemorrhage in the setting of systemic lupus erythematosus: a case report and review of noninfectious causes of acute pulmonary hemorrhage in adults. Case Reports in Rheumatology, 2021; 2021: 6620701.
LUQUETTI CM, et al. Lúpus eritematoso sistêmico: manifestações clínicas e diagnóstico. Brazilian Journal of Implantology and Health Sciences, 2024; 6(8): 5565-5576.
MARTÍNEZ-MARTÍNEZ MU e ABUD-MENDOZA C. Diffuse alveolar hemorrhage in patients with systemic lupus erythematosus: clinical manifestations, treatment, and prognosis. Reumatología Clínica, 2014; 10(4): 248-253.
MOK CC, LAU CS. Pathogenesis of systemic lupus erythematosus. Journal of Clinical Pathology, 2003; 56(7): 481-490.
MUDGAL M, et al. Connective Tissue Disorder-Induced Diffuse Alveolar Hemorrhage: A Comprehensive Review with an Emphasis on Airway and Respiratory Management. Life, 2025; 15(5): 793.
NOLASCO-AMEZCUA J, et al. Unilateral Alveolar Hemorrhage: A Rare Pulmonary Complication in Systemic Lupus Erythematosus. Cureus, 2024; 16(6): e61491.
RAUNIYAR S, et al. Diffuse alveolar hemorrhage as a rare initial presentation of systemic lupus erythematosus in early pregnancy: a case report. Clinical Case Reports, 2025; 13(9): e70839.
REIBALDI AA, et al. Hemorragia alveolar difusa en pacientes con lupus eritematoso sistémico. Reumatología Clínica, 2022; 18(2): 84-90.
SALAH QM, et al. Diffuse alveolar hemorrhage in an undiagnosed systemic lupus erythematosus patient. Cureus, 2023; 15(5): e38421.
SAWADA T, et al. Systemic lupus erythematosus and immunodeficiency. Immunological Medicine, 2019; 42(1): 1-9.
SHIN JI, et al. Systemic lupus erythematosus and lung involvement: a comprehensive review. Journal of Clinical Medicine, 2022; 11(22): 6714.
SUN Y, et al. Systemic lupus erythematosus–associated diffuse alveolar hemorrhage: a single-center, matched case–control study in China. Lupus, 2020; 29: 1-9.
TA R, et al. Diffuse alveolar hemorrhage in systemic lupus erythematosus: histopathologic features and clinical correlations. Case Reports in Pathology, 2017; 2017: 1936282.
XU L, et al. Risk factors of diffuse alveolar hemorrhage in Chinese patients with systemic lupus erythematosus. Scientific Reports, 2023; 13: 22381.
