Google Acadêmico | Citações: 16429 | índice h: 32 | índice i10: 482
Fatores que influenciam desfechos clínicos de adultos admitidos em unidade de terapia intensiva com injúria renal aguda associada à sepse
PDF

Palavras-chave

Injúria Renal Aguda
Terapia de Substituição Renal
Sepse
Unidades de Terapia Intensiva
Cuidados Críticos

Como Citar

Fatores que influenciam desfechos clínicos de adultos admitidos em unidade de terapia intensiva com injúria renal aguda associada à sepse. (2026). Revista Eletrônica Acervo Saúde, 26(2), e22969. https://doi.org/10.25248/reas.e22969.2026

Copyright © | Todos os direitos reservados.

A revista detém os direitos autorais exclusivos de publicação deste artigo nos termos da lei 9610/98.

Reprodução parcial
É livre o uso de partes do texto, figuras e questionário do artigo, sendo obrigatória a citação dos autores e revista.

Reprodução total
É expressamente proibida, devendo ser autorizada pela revista.

Resumo

Objetivo: Identificar os fatores que influenciam os desfechos clínicos de pacientes adultos admitidos em Unidade de Terapia Intensiva com injúria renal aguda associada à sepse (IRA-SA). Métodos: Revisão de escopo. A busca foi realizada nas bases de dados LILACS, PubMed/MEDLINE, Scopus e Web of Science. A amostra contém 19 artigos publicados entre 2020 e 2024. Foram extraídos autores, ano, país, delineamento metodológico e resultados. Em seguida, foram selecionados por leitura de título e resumo e, posteriormente, por leitura completa, com categorização por desfechos clínicos. A síntese dos resultados ocorreu de forma descritiva. Resultados: Os estudos demonstraram que o início precoce da IRA-SA, a persistência da disfunção renal e a maior gravidade clínica se associam a piores desfechos clínicos. Fatores como distúrbios hemodinâmicos, balanço hídrico positivo, biomarcadores emergentes, doença renal crônica, obesidade e diferenças metabólicas influenciaram estes significativamente. Observou-se concentração de estudos asiáticos e ausência de brasileiros. Considerações finais: Os achados reforçam a relevância do reconhecimento precoce da IRA-SA e da estratificação contínua do risco renal. A escassez de estudos nacionais e a heterogeneidade metodológica constituem limitações importantes.

PDF

Referências

AHN YH, et al. Early sepsis-associated acute kidney injury and obesity. JAMA Network Open, 2024; 7(2): e2354923.

LUO X, et al. Early recovery status and outcomes after sepsis-associated acute kidney injury in critically ill patients. Journal of Central South University Medical Sciences, 2022; 47(5): 535–545.

INCI K, et al. Factors and outcomes related to new-onset acute kidney injury in septic medical intensive care unit patients. Northern Clinics of Istanbul, 2024; 11(5): 414–421.

JIANG W, et al. The influence of gender on the epidemiology of and outcome from sepsis-associated acute kidney injury in ICU. European Journal of Medical Research, 2024; 29: 56.

KUWABARA S, et al. The pathophysiology of sepsis-associated AKI. Clinical Journal of the American Society of Nephrology, 2022; 17(7): 1050–1069.

LEGRAND M, et al. Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials. Critical Care, 2024; 28(1): 92.

LIN J, et al. Impact of cumulative fluid balance during continuous renal replacement therapy on mortality in patients with septic acute kidney injury. Frontiers in Medicine, 2021; 8: 762112.

CARLOS LMC, et al. Sepsis-associated acute kidney injury. Critical Care Clinics, 2021; 37(2): 279–301.

MONARD C, et al. Epidemiology and outcomes of early versus late septic acute kidney injury in critically ill patients. Anaesthesia, Critical Care & Pain Medicine, 2024; 43(1): 101332.

NANDAGOPAL N, et al. Comparison of epidemiology and outcomes of acute kidney injury in critically ill patients with and without sepsis. Indian Journal of Critical Care Medicine, 2020; 24(4): 258–262.

KDIGO. Clinical Practice Guideline for Acute Kidney Injury. Kidney International Supplements, 2012; 2(1): 1–138. Disponível em: http://www.kdigo.org/clinical_practice_guidelines/AKI.php. Acessado em: 29 de setembro de 2025.

OUZZANI M, et al. Rayyan—a web and mobile app for systematic reviews. Systematic Reviews, 2016; 5(1): 210.

PEERAPORNRATANA S, et al. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney International, 2019; 96(5): 1083–1099.

PENG J, et al. No sex differences in the incidence, risk factors and clinical impact of acute kidney injury in critically ill patients with sepsis. Frontiers in Immunology, 2022; 13: 895018.

POSTON JT, KOYNER JL. Sepsis associated acute kidney injury. BMJ, 2019; 364: k4891.

PRESCOTT HC, OSTERMANN M. What is new and different in the 2021 Surviving Sepsis Campaign guidelines. Medizinische Klinik Intensivmedizin und Notfallmedizin, 2023; 118(Suppl 2): 75–79.

RUDD KE, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017. Lancet, 2020; 395(10219): 200–211.

OMS. Sepsis. Organização Mundial da Saúde. 2024. Disponível em: https://www.who.int/news-room/fact-sheets/detail/sepsis. Acessado em: 29 set. 2025.

SEYMOUR CW, et al. Assessment of clinical criteria for sepsis: Sepsis-3. JAMA, 2016; 315(8): 762–774.

SINGER M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 2016; 315(8): 801–810.

SONG MJ, et al. Epidemiology of sepsis-associated acute kidney injury in critically ill patients. Critical Care, 2024; 28: 383.

TAKKAVATAKARN K, et al. Machine learning derived serum creatinine trajectories in acute kidney injury in critically ill patients with sepsis. Critical Care, 2024; 28: 156.

TAO X, et al. Combining renal cell arrest and damage biomarkers to predict progressive AKI in patients with sepsis. BMC Nephrology, 2021; 22: 415.

TRICCO AC, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR). Annals of Internal Medicine, 2018; 169(7): 467–473.

UHEL F, et al. Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis. Intensive Care Medicine, 2020; 46(8): 1576–1589.

WANG DH, et al. Attributable mortality of acute kidney injury among critically ill patients with sepsis. BMC Nephrology, 2024; 25: 125.

WANG M, et al. The effects of timing onset and progression of AKI on the clinical outcomes in AKI patients with sepsis. Renal Failure, 2023; 45(1): 1–10.

WANG Z, et al. Acute kidney injury-attributable mortality in critically ill patients with sepsis. PeerJ, 2022; 10: e13184.

WHITE KC, et al. Sepsis-associated acute kidney injury in the intensive care unit. Intensive Care Medicine, 2023; 49(9): 1079–1089.

WHITE KC, et al. Sepsis-associated acute kidney injury in patients with chronic kidney disease. Nephrology, 2024; 29(12): 838–848.

XU H, et al. L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury. Frontiers in Medicine, 2024; 11: 1500995.

YANG Y, et al. Incidence, risk factors and clinical outcomes of septic acute renal injury in cancer patients with sepsis admitted to the ICU. Frontiers in Medicine, 2022; 9: 1015735.

ZARBOCK A, et al. Sepsis-associated acute kidney injury: consensus report of the 28th ADQI workgroup. Nature Reviews Nephrology, 2023; 19(6): 401–417.