Resumo
Objetivo: Avaliar a eficácia da Terapia Fotodinâmica Antimicrobiana (TFDA) em usuários de próteses totais removíveis com Estomatite Protética (EP) associada a Candida albicans. Métodos: Trata-se de uma revisão sistemática, compreendendo estudos publicados entre 2015 e 2025, nas línguas portuguesa e inglesa. Utilizou-se como pergunta norteadora: A terapia fotodinâmica antimicrobiana apresenta eficácia significativa na redução da colonização por C. albicans e na melhora dos sinais e sintomas clínicos em pacientes com estomatite protética? A busca foi realizada nas bases de dados PubMed, Lilacs, MedLine, Livivo e SciELO, além da literatura cinzenta no Google Scholar e Open Grey, por meio dos descritores: "Stomatitis”, “Photodynamic Therapy” e “Candida albicans”, intercalados pelos operadores booleanos “AND”. Resultados: Após os critérios de elegibilidade, foram selecionados seis ensaios clínicos randomizados que compararam a TFDA a terapias medicamentosas, cujos resultados demonstraram que a TFDA apresenta eficácia equivalente e, em alguns casos, superior à dos tratamentos tradicionais, mesmo diante da variabilidade de protocolos. Considerações finais: Os estudos indicam que a TFDA apresenta eficácia significativa na redução das colônias fúngicas e na melhora dos sintomas e sinais clínicos da EP.
Referências
ABUHAJAR E, et al. Management of chronic atrophic candidiasis (denture stomatitis): a narrative review. International Journal of Environmental Research and Public Health, 2023; 20(4): e3029.
AFROOZI B, et al. Comparison of the efficacy of indocyanine green-mediated photodynamic therapy and nystatin therapy in treatment of denture stomatitis. Photodiagnosis and Photodynamic Therapy, 2019; 27: 193–197.
AL-QAHTANI MA. Efficacy of antimicrobial photodynamic therapy in disinfection of Candida biofilms on acrylic dentures: a systematic review. Photodiagnosis and Photodynamic Therapy, 2022; 40: e102980.
ALRABIAH M, et al. Efficacy of photodynamic therapy versus local nystatin in the treatment of denture stomatitis: a randomized clinical study. Photodiagnosis and Photodynamic Therapy, 2019; 28: 98–101.
ALVES F, et al. A randomized clinical trial evaluating photodithazine-mediated antimicrobial photodynamic therapy as a treatment for denture stomatitis. Photodiagnosis and Photodynamic Therapy, 2020; 32: e102041.
BASUNBUL GI. Oral health-related quality of life among denture stomatitis patients with implant overdenture treated with photodynamic therapy. Oral Health & Preventive Dentistry, 2024; 22: 107–114.
BUDTZ-JÖRGENSEN E, HOLMSTRUP P, KROGH P. Fluconazole in the treatment of Candida-associated denture stomatitis. Antimicrobial Agents and Chemotherapy, 1988; 32(12): 1859–1863.
CORREIA JH, et al. Photodynamic therapy review: principles, photosensitizers, applications, and future directions. Pharmaceutics, 2021; 13(9): e1332.
DE SENNA AM, et al. Photodynamic inactivation of Candida spp. on denture stomatitis: a clinical trial involving palatal mucosa and prosthesis disinfection. Photodiagnosis and Photodynamic Therapy, 2018; 22: 212–216.
FIEGLER-RUDOL J, et al. Evaluating the efficacy of Rose Bengal as a photosensitizer in antimicrobial photodynamic therapy against Candida albicans: a systematic review. International Journal of Molecular Sciences, 2025; 26(11): e5034.
LABBAN N, et al. Efficacy of Rose Bengal- and curcumin-mediated photodynamic therapy for the treatment of denture stomatitis in patients with habitual cigarette smoking: a randomized controlled clinical trial. Photodiagnosis and Photodynamic Therapy, 2021; 35: e102380.
ŁOPACIŃSKI M, et al. Riboflavin- and hypericin-mediated antimicrobial photodynamic therapy as alternative treatments for oral candidiasis: a systematic review. Pharmaceutics, 2025; 17(1): e33.
LOPES JP, LIONAKIS MS. Pathogenesis and virulence of Candida albicans. Virulence, 2022; 13(1): 89–121.
MACIEL CM, et al. Methylene blue-mediated photodynamic inactivation followed by low-level laser therapy versus miconazole gel in the treatment of denture stomatitis. Journal of Prosthodontics, 2016; 25(1): 28–32.
MARDANI M, KAMRANI O. Effectiveness of antimicrobial photodynamic therapy with indocyanine green against standard and fluconazole-resistant Candida albicans. Lasers in Medical Science, 2021; 36(9): 1971–1977.
MARTÍNEZ-SERNA IV, et al. Does microwave and hydrogen peroxide disinfection reduce Candida albicans biofilm on polymethyl methacrylate denture surfaces? The Journal of Prosthetic Dentistry, 2022; 128(5): 1068–1074.
MCREYNOLDS DE, et al. Denture stomatitis - An interdisciplinary clinical review. Journal of Prosthodontics, 2023; 32(7): 560-570.
MIMA EG, et al. Comparison of photodynamic therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial. Clinical Microbiology and Infection, 2012; 18(10): 380–388.
NEWTON AV. Denture sore mouth: a possible etiology. British Dental Journal, 1962; 112: 357–360.
RAKASEVIC D, et al. Evaluation of photodynamic therapy efficacy versus conventional antifungal therapy in patients with poor-fitting dentures suffering from denture stomatitis: a prospective clinical study. Photodiagnosis and Photodynamic Therapy, 2024; 45: e103913.
SATALA D, et al. The role of Candida albicans virulence factors in the formation of multispecies biofilms with bacterial periodontal pathogens. Frontiers in Cellular and Infection Microbiology, 2022; 11: e765942.
WIENCH R, et al. Efficacy of toluidine blue-mediated antimicrobial photodynamic therapy on Candida spp.: a systematic review. Antibiotics, 2021; 10(4): e349.
WIENCH R, et al. Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications. International Journal of Molecular Sciences, 2025; 26(16): e8049.
YANG F. Pathogenesis and preventions of denture stomatitis. Journal of Central South University (Medical Sciences), 2023; 48(9): 1411–1418.
