Palavras-chave
Flavonóides
Neurodegeneração
Terapias antioxidantes
Como Citar
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Resumo
Objetivo: Revisar sistematicamente as evidências científicas sobre o potencial neuroprotetor da polidatina e da quercetina em doenças neurodegenerativas. Métodos: Trata-se de uma revisão sistemática qualitativa e descritiva, realizada nas bases de dados PubMed e SciELO, utilizando os descritores MeSH e DeCS combinados por operadores booleanos. Foram incluídos estudos publicados entre 2020 e 2025. Resultados: Foram selecionados 9 estudos acerca da temática, sendo extraídos: o antioxidante, o título e o ano de publicação, o objetivo, a metodologia, o mecanismo de ação e a conclusão para a realização da análise. Os resultados indicaram que a polidatina e a quercetina apresentaram atividades neuroprotetoras consideradas relevantes, atuando na modulação de vias biológicas associadas à neurodegeneração e na atenuação de sintomas. Considerações finais: Os dados analisados fortalecem que os antioxidantes são uma alternativa promissora, com uma gama de atividades, não apenas minimizando sintomas das doenças neurodegenerativas e os efeitos colaterais causados pelos fármacos atuais, mas também de modular os processos biológicos que conduzem à neurodegeneração.
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