Palavras-chave
Estresse oxidativo
Neoplasias da mama
Radioterapia
Vitamina A
Como Citar
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Resumo
Objetivo: Avaliar a associação entre níveis séricos de vitamina A e características tumorais em pacientes com câncer de mama submetidas à radioterapia, com ênfase nos receptores hormonais e no subtipo triplo-negativo. Métodos: Estudo de coorte prospectivo realizado entre fevereiro e junho de 2025 com 50 mulheres com câncer de mama submetidas à cirurgia primária e encaminhadas à radioterapia em centro oncológico no Rio de Janeiro. Coletaram-se dados clínicos e de estilo de vida. A vitamina A sérica foi dosada por cromatografia líquida de alta eficiência antes da radioterapia. Definiu-se deficiência como <0,30 mg/L. Utilizaram-se testes t, qui-quadrado ou Fisher e risco relativo (α=5%). Resultados: A média de idade foi 54,6 ± 12,2 anos; 26% apresentaram deficiência de vitamina A. Tumores ER+ e PR+ apresentaram níveis mais elevados que os negativos. O subtipo triplo-negativo apresentou menores níveis médios e maior prevalência de deficiência (RR=3,43). Não houve associação com IMC, tabagismo, etilismo, HER2 ou quimioterapia prévia. Conclusão: A deficiência de vitamina A associou-se a tumores sem receptores hormonais, especialmente ao subtipo triplo-negativo.
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