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Apneia obstrutiva do sono como fator associado à hipertensão arterial sistêmica em adultos
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Adultos
Apneia obstrutiva do sono
Hipertensão

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Apneia obstrutiva do sono como fator associado à hipertensão arterial sistêmica em adultos. (2026). Revista Eletrônica Acervo Saúde, 26(6), e23931. https://doi.org/10.25248/reas.e23931.2026

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Resumo

Objetivo: Analisar a associação entre apneia obstrutiva do sono e hipertensão em adultos, avaliando a magnitude dessa relação e sua possível contribuição como fator independente no difícil controle da pressão arterial. Métodos: Trata-se de uma revisão integrativa da literatura realizada através das bases PubMED, Biblioteca Virtual em Saúde (BVS) e Periódico CAPES, usando os descritores: ​​”Sleep Apnea, Obstructive”, “Hypertension”, “Drug”, e obtendo o truncamento de pesquisa: (Sleep Apnea, Obstructive) AND (Hypertension) AND (Drug). Foram encontrados 2.857 artigos, filtrados conforme critérios de inclusão (idiomas português, inglês e espanhol; período de 2021 a 2026; artigos completos) e exclusão (artigos duplicados, resumos, fora do escopo). Resultados: A apneia obstrutiva do sono está fortemente associada ao desenvolvimento, manutenção e maior gravidade da hipertensão arterial, especialmente em casos mais avançados. Seus mecanismos envolvem hipóxia intermitente, ativação simpática, inflamação e disfunção endotelial, contribuindo para maior risco cardiovascular e resistência ao tratamento. Além disso, a identificação e o manejo integrado da AOS são fundamentais para melhorar o controle pressórico e reduzir desfechos adversos. Conclusão: A apneia obstrutiva do sono é um importante fator determinante e agravante da hipertensão arterial. Seu reconhecimento e manejo são essenciais para otimizar o controle pressórico e reduzir o risco cardiovascular.

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Referências

CHARCHAR FJ, et al. Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension. Journal of Hypertension, 2024; 42(1): 23–49.

CHENG H, et al. Efficacy and safety of solriamfetol on excessive daytime sleepiness associated with obstructive sleep apnea in China: A phase 3, multicenter, double-blind, placebo-controlled randomized clinical trial. CNS Drugs, 2026; 40(1): 83–98.

GUO Y, et al. Nocturnal nasal congestion is associated with uncontrolled blood pressure in patients with hypertension comorbid obstructive sleep apnea. European Archives of Oto-Rhino-Laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022; 279(11): 5215–5221.

KANI J, et al. The impact of obstructive sleep apnea and heart rate on arterial stiffness: results from the Tokyo Sleep Heart Study. Hypertension Research, 2025; 48(11): 2792–2800.

KOVBASYUK Z, et al. Obstructive sleep apnea, platelet aggregation, and cardiovascular risk. Journal of the American Heart Association, 2024; 13(15): e034079.

LEE EJ; KIM SJ. Association of obstructive sleep apnea and uncontrolled hypertension in the middle aged 40-59 in Korean population. Journal of Korean Medical Science, 2025; 40(24): e129.

LIN H, et al. Association of estimated pulse wave velocity with all-cause mortality and cardiovascular mortality in obstructive sleep apnea patients: results from NHANES. Frontiers in Cardiovascular Medicine, 2025; 12(1): 1571610.

LIU J, et al. Management of nocturnal hypertension: An expert consensus document from Chinese Hypertension League. Journal of Clinical Hypertension (Greenwich, Conn.), 2024; 26(1): 71–83.

LOH HH, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. Journal of Translational Medicine, 2025; 23(1): 296.

LOWERY MM, et al. Sleep-related hypoxia, right ventricular dysfunction, and survival in patients with group 1 pulmonary arterial hypertension. Journal of the American College of Cardiology, 2023; 82(21): 1989–2005.

LUCCA MB, et al. Effects of chlorthalidone plus amiloride compared with amlodipine on short-term blood pressure variability in individuals with hypertension and obstructive sleep apnea: a randomized controlled trial. Blood Pressure Monitoring, 2023; 28(6): 289–294.

NISHIMURA A, et al. Obstructive sleep apnea during rapid eye movement sleep in patients with diabetic kidney disease. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 2021; 17(3): 453–460.

PIHTILI A, et al. Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort. Sleep Medicine, 2025; 126(1): 228–234.

SANSOM K, et al. The interrelationships between sleep regularity, obstructive sleep apnea, and hypertension in a middle-aged community population. Sleep, 2024; 47(3).

SU W, et al. Higher apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) were independently associated with increased risks of hypertension in patients with T2DM: A cross-sectional study. International Journal of Hypertension, 2021; 2021(1): 8887944.

SULTANA R, et al. The case for early use of glucagon-like peptide-1 receptor agonists in obstructive sleep apnea patients with comorbid diabetes and metabolic syndrome. Life (Basel, Switzerland), 2022; 12(8): 1222.

SUN X, et al. Comparing the effects of supplemental oxygen therapy and continuous positive airway pressure on patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials. Schlaf & Atmung [Sleep & Breathing], 2021; 25(4): 2231–2240.

SVEDMYR S, et al. Blood pressure control in hypertensive sleep apnoea patients of the European Sleep Apnea Database cohort - effects of positive airway pressure and antihypertensive medication. European Heart Journal Open, 2023; 3(6): 109.

SVEDMYR S, et al. Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine. Journal of Sleep Research, 2023; 32(4): e13811.

TABRIZCHI R, et al. Management of drug-resistant hypertension as a heterogeneous disorder. Pharmacology & Therapeutics, 2025; 271(108875): 108875.

TAN L, et al. Effect of acetazolamide on obstructive sleep apnoea in highlanders: protocol for a randomised, placebo-controlled, double-blinded crossover trial. BMJ Open, 2022; 12(3): e057113.

WANG D, et al. The long-term impact of expansion sphincter pharyngoplasty treatment on blood pressure control and health-related quality of life in patients with obstructive sleep apnea and hypertension. Schlaf & Atmung [Sleep & Breathing], 2021; 25(4): 2155–2162.

YAO X, et al. The association between blood pressure control and long-term cardiovascular outcomes in Hypertension coexistent with obstructive sleep apnea. BMC Cardiovascular Disorders, 2023; 23(1): 574.

ZAREMBA S, et al. Aneurysm size and blood pressure severity in patients with intracranial aneurysms and sleep apnea. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 2022; 18(6): 1539–1545.