Palavras-chave
Anestesia obstétrica
Cetamina
Escetamina
Como Citar
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Resumo
Objetivo: Analisar o impacto da analgesia neuraxial e da administração perioperatória de cetamina ou escetamina na incidência e na gravidade da DPP. Métodos: Trata-se de revisão integrativa, realizada nas bases PubMed/MEDLINE e BVS, incluindo ensaios clínicos e revisões sistemáticas publicados entre 2020 e 2025, nos idiomas português e inglês. A amostra final totalizou 11 estudos. Resultados: A escetamina demonstrou eficácia superior à cetamina racêmica, reduzindo o risco de DPP em 57% a curto prazo. Seus mecanismos envolvem antagonismo NMDA, aumento do BDNF e ação anti-inflamatória. Já a analgesia neuraxial apresentou resultados heterogêneos, sem proteção universal, mas com benefícios observados em nulíparas e populações asiáticas. Considerações finais: A escetamina é promissora na profilaxia de curto prazo, enquanto a analgesia neuraxial não deve ser utilizada isoladamente para prevenção da DPP.
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