Resumo
Objetivo: Avaliar a eficácia de intervenções multiníveis na prevenção do suicídio, com foco em ensaios clínicos randomizados. Métodos: Trata-se de uma revisão sistemática com meta-análise, conduzida através das diretrizes PRISMA e registrada no PROSPERO, incluindo buscas nas bases PubMed e PsycINFO. Os dados foram analisados através da meta-análise, forest-plot e I2, foi considerado o p < 0,05. Resultados: Foram analisados 60 estudos qualitativamente e 15 quantitativamente, totalizando 7.327 participantes no grupo intervenção e 8.577 no controle. Os resultados indicaram efeito global significativo favorável às intervenções (d = -0,32; IC95%: -0,33 a -0,31; Z = 47,43; p < 0,00001). As intervenções baseadas em terapia cognitivo-comportamental mostraram maior eficácia. Conclusão: Conclui-se que intervenções multiníveis são efetivas na redução da ideação suicida e sintomas associados, embora a elevada heterogeneidade e a concentração de estudos em países de alta renda apontem para a necessidade de adaptações contextuais e ampliação de pesquisas em diferentes realidades socioculturais.
Referências
ASNAKE AA, et al. Multilevel analysis of factors associated with suicide attempts: Evidence from 2022/2023 Mozambique Demographic and Health Survey. PLOS ONE, 2025, 20(2): e0315648.
BANDARA P, et al. Cost-effectiveness of Installing Barriers at Bridge and Cliff Sites for Suicide Prevention in Australia. JAMA Netw Open, 2022, 5(4): p. e226019.
BARNHORST A, et al. Suicide prevention efforts in the United States and their effectiveness. Current Opinion in Psychiatry, 2021, 34(3): 299–305.
BERMAN A, et al. Effectiveness of restricting access to a suicide jump site: a test of the method substitution hypothesis. Inj Prev, 2022, 28(1): 90–92.
BÜSCHER R, et al. Internet-based cognitive behavioral therapy to reduce suicidal ideation: A systematic review and meta-analysis. JAMA Network Open, 2020, 3(4): e203933.
CONNOR R, KIRTLEY OJ. The integrated motivational-volitional model of suicidal behavior. Philos Trans R Soc Lond B Biol Sci, 2018, 373(1754): 20170268.
CRUZ WGN, et al. Analysis of the impact of the Brazilian Suicide Prevention Campaign "Yellow September": an ecological study. Trends in Psychiatry and Psychotherapy, 2024, 46: e20240564.
DIMENSTEIN M, et al. Determinação social da saúde mental: Contribuições à psicologia no cuidado territorial. Arquivos Brasileiros de Psicologia, 2017, 69(2): 72–87.
FELTZ-CORNELIS CM, et al. Best Practice Elements of Multilevel Suicide Prevention Strategies: A Review of Systematic Reviews. Crisis, 2011, 32(6): 319–333.
GRATTIDGE L, et al. Characteristics of suicide prevention programs implemented for young people in rural areas: A systematic review of the literature. Mental Health & Prevention, 2024, 34: 200335.
HEGERL U, et al. The 4-level approach: Prevention of suicidal behaviour through community-based intervention. Frontiers in Psychiatry, 2021, 12: 760491.
HOFMANN SG, et al. The efficacy of cognitive behavioral therapy: A review of meta-analyses. Cognitive Therapy and Research, 2012, 36(5): 427–440.
HOFSTRA E, et al. Effectiveness of suicide prevention interventions: A systematic review and meta-analysis. General Hospital Psychiatry, 2020, 63: 127–140.
KATZ I, et al. Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder. JAMA Psychiatry, 2022, 79(1): 1–10.
KNOX KL, et al. The US Air Force Suicide Prevention Program: Implications for Public Health Policy. American Journal of Public Health, 2010, 100(12): 2457–2463.
LINDKVIST R, et al. Brief admission by self-referral as an add-on to usual care for individuals with self-harm at risk of suicide: cost-effectiveness and 4-year health-economic consequences after a Swedish randomized controlled trial. Nordic Journal of Psychiatry, 2024, 78(6): 497-506.
LINTHICUM K, RIBEIRO, J. Suicide plan prevalence, recurrence, and longitudinal association with nonfatal suicide attempt. Suicide Life Threat Behav, 2022, 52(6): 1062–1073.
MANN JJ, et al. Suicide Prevention Strategies: A Systematic Review. JAMA, 2005, 294(16): 2064, 2005.
MARBACK RF, PELISOLI C. Terapia cognitivo-comportamental no manejo da desesperança e pensamentos suicidas. Rev. bras.ter. cogn., 2014, 10(2): 122-129.
MCCAULEY E, et al. Efficacy of Dialectical Behavior Therapy for Adolescents at High Risk for Suicide: A Randomized Clinical Trial. JAMA Psychiatry, 2018, 75(8): 777.
MITTMAN BS. Creating the Evidence Base for Quality Improvement Collaboratives. Annals of Internal Medicine, 2004, 140(11): 897, 2004.
NAGAFUCHI T. Um olhar antropológico sobre o suicídio: devir, formas de vida e subjetividades. Revista M, 2019, 4(7): 101-124.
OLIVEIRA MEC, et al. Série temporal do suicídio no Brasil: o que mudou após o Setembro Amarelo? Revista Eletrônica Acervo Saúde, 2020, 48: e3191.
ONO Y, et al. Effectiveness of a Multimodal Community Intervention Program to Prevent Suicide and Suicide Attempts: A Quasi-Experimental Study. PLoS ONE, 2013, 8(10): e74902.
OUGRIN D, et al. Therapeutic interventions for suicide attempts and self-harm in adolescents: Systematic review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry, 2015, 54(2): 97–107.
PATEL V, et al. The Lancet Commission on global mental health and sustainable development. The Lancet, 2018, 392(10157): 1553–1598.
PATEL V, EATON, J. Principles to guide mental health policies in low- and middle-income countries. Revista Brasileira de Psiquiatria, 2010, 32(4): 343–346.
PINHEIRO IL, PEREIRA CCQ. Suicídio como sintoma social: um estudo sobre os impactos do capitalismo nas subjetividades. Revista Polis e Psique, 2023, 13(2): 76-96.
PLANCKE L, et al. Effectiveness of a French Program to Prevent Suicide Reattempt (VigilanS). Archives of Suicide Research, 2021, 25(3): 570–581.
POWER J, et al. Adapting health interventions for local fit when scaling-up: A realist review protocol. BMJ Open, 2019, 9(1): e022084.
RICHARD O, et al. Simulation training in suicide risk assessment and intervention: a systematic review and meta-analysis. Medical Education Online, 2023, 28(1): 2199469.
SAKASHITA T, HIROFUMI OH. Suicide Prevention Interventions and Their Linkages in Multilayered Approaches for Older Adults: A Review and Comparison. Frontiers in Public Health, 2022, 10.
SCHMECKENBECHER J, et al. Predictive validity of suicide risk assessment tools in the psychiatric emergency department: Systematic review and meta-analysis. BJPsych Open, 2022, 8(4): e125.
SCHMECKENBECHER J, et al. Effectiveness of distance-based suicide interventions: multi-level meta-analysis and systematic review. BJPsych Open, 2022, 8(4): e140.
SKIVINGTON K, et al. A new framework for developing and evaluating complex interventions: Update of Medical Research Council guidance. BMJ, 2021, 374: n2061.
TARRIER N, et al. Cognitive-behavioral interventions to reduce suicide behavior: A systematic review and meta-analysis. Behavior Modification, 2008, 32(1): 77–108.
TRICKETT EJ, BEEHLER S. The Ecology of Multilevel Interventions to Reduce Social Inequalities in Health. American Behavioral Scientist, 2013, 57(8): 1227–1246.
TURECKI G, BRENT DA. Suicide and suicidal behaviour. The Lancet, 2016, 387(10024): 1227–1239.
WENZEL A, BECK AT. A cognitive model of suicidal behavior: Theory and treatment. Applied and Preventive Psychology, 2008, 12(4): 189-201.
WENZEL A, JAGER-HYMAN S. Cognitive Therapy for Suicidal Patients: Current Status. The Behavior Therapist, 2012, 35(7): 121-130.
WHO. 2013. In: Mental health action plan 2013–2020. Geneva: World Health Organization. Disponível em: https://www.who.int/publications/i/item/9789241506021. Acesso em: 06 mar. 2026.
WHO. 2018. In: National suicide prevention strategies: progress, examples and indicators. Geneva: World Health Organization. Disponível em: https://www.who.int/publications/i/item/national-suicide-prevention-strategies-progress-examples-and-indicators. Acesso em: 10 abr. 2026.
WHO. 2021. In: Suicide worldwide in 2019: global health estimates. Geneva: World Health Organization. Disponível em: https://www.who.int/publications/i/item/9789240026643. Acesso em: 10 jan. 2026.
WHO. 2022. In: Global status report on the public health. Geneva: World Health Organization. Disponível em: https://www.sbponline.org.br/arquivos/9789240049338-eng.pdf. Acesso em: 02 dez. 2025.
