Abstract
Objective: To evaluate the challenges in the diagnosis and treatment of pediatric primary arterial hypertension, considering the effectiveness of diagnosis, adherence to treatment, quality of life, blood pressure control and long-term impact. Methods: This is an integrative review developed by searching the PubMed database, using the following search strategy (((Hypertension) AND ((Child) OR (Adolescent)) AND (((Treatment) AND (Diagnosis) OR (Management))) NOT ((Adult) OR (Newborn) OR (Pregnancy)). A total of 3075 articles were found, 60 of which were pre-selected after applying the inclusion and exclusion criteria. 41 were removed after initial reading and analysis, totaling 19 for full analysis. Results: The studies point to the relationship between obesity and a sedentary lifestyle and cases of pediatric hypertension. As it is a silent disease with non-specific symptoms, late treatment and approaches can lead to an increase in cardiovascular events. Dietary measures are emphasized as the main therapeutic approach, with few studies focusing on medications that are confirmed to be safe. Final considerations: The importance of lifestyle changes is highlighted, as well as rigorous screening measures to prevent future complications.
References
ALABDULKADER AM, et al. Pediatric Hypertension: Parent Perspectives. Glob Pediatr Health, 2020; 7: 2333794X20981340.
ANGOORANI P, et al. Determinants of childhood blood pressure using structure equation model: the CASPIAN-V study. BMC Cardiovasc Disord, 2020; 20(1): 193.
BARATI L, et al. Overweight and obesity: worldwide risk factors for pediatric hypertension. Revista ARYA atherosclerosis, 2021; 18: 1-6.
CHAIG A, et al. Detecting and Managing Childhood Onset Hypertension in Africa: A Call to Action. Current Hypertension Reports, 2023; 1-20.
CHEN Y, et al. Characteristics of pediatric inpatients with primary and secondary hypertension. Pediatr Investig, 2021; 5(1): 28-32.
COULTHARD MG. Managing severe hypertension in children. Pediatric Nephrology, 2023; 1: 11.
FISHMAN B, et al. Adolescent Hypertension and Risk for Early-Onset Type 2 Diabetes: A Nationwide Study of 1.9 Million Israeli Adolescents. Diabetes Care, 2021; 44(1): 6-8.
GENOVESI S, et al. GENOVESI, Simonetta et al. Effects of lifestyle modifications on elevated blood pressure and excess weight in a population of Italian children and adolescents. American journal of hypertension, 2018; 31(10): 1147-1155.
GUZMAN-LIMON M, et al. Pediatric Hypertension: Diagnosis, Evaluation, and Treatment. Pediatr Clin North Am, 2019; 66(1): 45-57.
HE H, et al., Body composition and serum total calcium were associated with blood pressure among children and adolescents aged 7–18 in China: a cross-sectional study. Frontiers in Pediatrics, 2020; 7: 411.
HSU CY, et al. Are Body Composition Parameters Better than Conventional Anthropometric Measures in Predicting Pediatric Hypertension?. International journal of environmental research and public health, 2020; 17(16): e5771.
IZADI A, et al. The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemic factors with low-sodium seafood rich in omega-3 fatty acids. Lipids in health and disease, 2020; 19(1): 1-13.
JONES L, et al. 20 years on - the measurement of blood pressure and detection of hypertension in children and adolescents: a national descriptive survey. J Hum Hypertens, 2023; 1: 15.
KHARBANDA EO, et al. Improving hypertension recognition in adolescents, a small but important first step in cardiovascular disease prevention. Academic pediatrics, 2020; 20(2): 163-165.
LEOPOLD S, ZACHARIAH JP. Pediatric Obesity, Hypertension, Lipids. Curr Treat Options Pediatr, 2020; 6(2): 62-77.
LURBE E, et al. Joint statement for assessing and managing high blood pressure in children and adolescents: Chapter 1. How to correctly measure blood pressure in children and adolescents. Revista Fontiers in pediatrics, 2023; 11: 1-9.
MOURATO FA, et al. Height-based equations can improve the diagnosis of elevated blood pressure in children. American Journal of Hypertension, 2018; 31(9): 1059-1065.
ORTIZ-PINTO MA, et al. Association between general and central adiposity and development of hypertension in early childhood. European Journal of Preventive Cardiology, 2019; 26(12): 1326-1334.
PERAK AM, BENUCK I. Preserving Optimal Cardiovascular Health in Children. Pediatr Ann, 2018; 47(12): e479–e486.
QIAN, Qin et al. Real-World Prescribing Patterns for Hypertensive Children in China from 2018 to 2021: A Cross-Sectional Multicenter Study. Risk Management and Healthcare Policy, 2023; 287-299.
RAINA R, et al. Hypertensive crisis in pediatric patients: an overview. Revista Frontiers in Pediatrics, 2020; 8: 1-17.
REDON J, et al. Narrative update of clinical trials with antihypertensive drugs in children and adolescents. Front Cardiovasc Med, 2022; 9: e1042190.
SINHA R, et al. American Academy of Pediatrics clinical practice guidelines for screening and management of high blood pressure in children and adolescents: what is new?. Indian Pediatrics, 2019; 56(4): 317-321.
THOMAS J, et al. Pediatric hypertension: Review of the definition, diagnosis, and initial management. Int J Pediatr Adolesc Med, 2022; 9(1): 1-6.
WANG Z, et al. Clinical follow-up study of 166 cases of children with hypertension. Translational Pediatrics, 2021; 10(7): 1834.
WÜHL E, et al. Joint statement for assessing and managing high blood pressure in children and adolescents: Chapter 2. How to manage high blood pressure in children and adolescents. Front Pediatr, 2023; 11: e1140617.
