Keywords
Endoplasmic reticulum
Endoplasmic reticulum stress
Systematic review
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Abstract
Objetivo: Relacionar las causas del estrés del retículo endoplasmático con la diabetes mellitus tipo 2 y sus complicaciones. Métodos: Se trata de una revisión sistemática que siguió la Declaración PRISMA (2020). Se realizaron búsquedas en las bases de datos PubMed y la Biblioteca de Literatura Médica en Línea de Medicina (MEDLINE) a través de la Biblioteca Virtual en Salud (BVS) utilizando los descriptores de ciencias de la salud "estrés del retículo endoplasmático" y "diabetes mellitus". Resultados: La búsqueda sistemática arrojó 2,047 artículos, y después de aplicar criterios de inclusión y exclusión, quedaron 440 estudios. Sin embargo, solo se utilizaron 15 artículos para la síntesis narrativa, que fueron estudios primarios que presentaron la relación entre los aspectos bioquímicos inherentes al estrés del retículo endoplasmático y la diabetes mellitus tipo 2. Consideraciones finales: Esta revisión identificó los mecanismos involucrados en el estrés del retículo endoplasmático y destacó su importancia crucial para los avances en el diagnóstico y tratamiento de la diabetes mellitus tipo 2, una enfermedad común en la sociedad contemporánea.
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