Keywords
Gut-brain axis
Autism Spectrum Disorder
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Abstract
Objective: Several studies point to a shine of bidirectional communication between intestinal microbiota and the central nervous system associated with cognitive and neurodegenerative disorders and intestinal symptoms. In this sense, the present study aims to analyze, through an integrative review, the works that evaluate whether there is a relationship between the intestinal microbiota and autism spectrum disorder. Methods: To build a methodology, two databases of medical-scientific content were consulted: PubMed and Lilacs. The search covered articles in English published between 2014 and 2024, focusing on primary articles. A total of 149 articles were found, of which 134 were excluded because they did not fit the proposed theme, resulting in 13 articles for analysis. Results: During the development of the work, it was found that the interaction of the gut-brain axis has a strong influence on the intestinal microbiota of individuals on the autism spectrum, which can lead to an imbalance in this microbiome. Final considerations: An important causal influence of the bidirectional brain-intestine-microbiota axis was found in the etiology and worsening of clinical manifestations of Autism Spectrum Disorder due to intestinal dysbiosis and gastrointestinal factors of idiopathic origin.
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