Keywords
IL-1β
Single nucleotide polymorphism
Viral diseases
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Abstract
Objective: Investigate the relationship between the SNP rs1143634 and viral diseases based on scientific literature, in order to understand the role of this SNP in the context of infection and identify possible risk factors. Method: A scoping review was conducted by analyzing articles from the National Center for Biotechnology Information (NCBI) and databases such as PubMed, Virtual Health Library (VHL), and Web of Science. Search terms included "IL-1β," "Polymorphism," "Single Nucleotide Polymorphism," and "Viral Diseases. Results: Initially, 272 studies were found in different databases. However, 266 were excluded for not meeting the inclusion criteria. Thus, six studies were included in the second phase and analyzed in depth, which related the rs1143634 SNP to Hepatitis B (HBV, n=1), Hepatitis C (HCV, n=2), Cytomegalovirus (CMV, n=1), and HIV (n=2). The results showed that the rs1143634 SNP plays an important role in the inflammatory response and the risk of infection for various viral diseases. Final considerations: Although limited, studies suggest an association between the rs1143634 SNP and infections by HCMV, HBV, HCV, and HIV. Further research is needed to clarify its role in viral diseases.
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