Abstract
Objective: To evaluate the impact of adverse reactions on the clinical outcome in patients treated for multiresistant tuberculosis. Methodology: An observational, retrospective cohort study of cases of MRT registered on SITE-TB, which underwent treatment from January 2010 to December 2015. Results: A total of 152 patients who presented with a mean age of 40, 2 years old, predominantly male (65.1%). The majority of the patients was concentrated in the metropolitan region of Belém (73.7%), with a predominance of the unemployed (25%). Significant share presented secondary resistance (88.2%). Regarding drug use, alcohol use was more frequent (20.4%), followed by illicit drugs (16.5%) and tobacco (5.3%). The presence of comorbidities was 27.6%, and Diabetes Mellitus was the most common (23%). Half of the patients in the study had adverse reactions and the most significant were arthralgia (31.6%), epigastric pain (15.1%) and peripheral neuropathy (5.3%). The favorable clinical outcome was predominant in 77% of the cases. Among the patients presenting with comorbidity, the majority presented a favorable outcome (88.1%). As well as those with adverse effects also had a more favorable outcome (79.0%), however this data did not reach statistical significance (p = 0.563). The users of illicit drugs and tobacco showed a higher frequency of unfavorable outcomes (56.0% and 62.5%, respectively). Conclusion: Multidrug-resistant tuberculosis remains an important public health problem, with high frequency, especially among the economically active population.