Abstract
Objective: Review available scientific traits on the use and use of metformin during pregnancy. Methods: A bibliographic review method was developed, based on the selection of articles from the Scielo, Lilacs, Medline and PubMed health research database, using the following descriptors: Metformin ; Pregnancy; Gestational diabetes. Results: There are no reports in the literature of increased complications from the use of metformin as a treatment for gestational diabetes. Some side effects that appear are gastrointestinal, such as nausea and diarrhea, but over time decrease with dose reduction or concomitant food intake. In terms of efficacy in glycemic control, metformin and insulin were found to have comparable results, with fasting glucose being similar in both groups. Risk factors for GDM are recommended to be investigated at the first prenatal visit. Conclusion: Metformin has been shown to be safe during pregnancy, with no evidence of increased rate of congenital malformations, neonatal sepsis, fetal death or trauma. during childbirth by literature. It is noteworthy that metformin is a drug that plays an important role in the treatment of diabetes. Its use throughout pregnancy reduces the incidence of some complications associated with the disease, such as gestational diabetes, preeclampsia and risk of miscarriage.