Abstract
Objective: To analyze the impact of mobile applications on screening and care management for people with neurocognitive disorders associated with the human immunodeficiency virus (HIV). Methods: An integrative literature review was conducted using PubMed, LILACS Plus, CAPES Journals, and Semantic Scholar databases. This study included studies involving patients with neurocognitive disorders associated with HIV, published in English, Portuguese, or Spanish between 2014 and 2024 in indexed journals. Results: The results were analyzed descriptively. Four hundred and sixty-eight articles published in national and international journals were selected after three phases of evaluation: selection, reading, and eligibility. Fifteen were analyzed, and five were ultimately included. All five studies demonstrated efficacy in neurocognitive screening for people living with HIV. The applications demonstrated sufficient acceptability and practicality for professional use in diverse clinical settings, even with limited resources. Conclusion: This integrative review identified that, in intervention studies, the detection rates of neurocognitive disorders were comparable to those of gold standard tests, but there were limitations in the management of care for people living with HIV.
References
AITA SL, et al. Psychometric utility of the international HIV dementia scale and Montreal Cognitive Assessment in HIV-associated asymptomatic neurocognitive impairment. Journal of neurovirology, 2021; 27(4): 568-578
ALMEIDA F, et al. Neurocognitive evaluation using the International HIV Dementia Scale (IHDS) and Montreal Cognitive Assessment Test (MoCA) in an HIV‐2 population. HIV medicine, 2021; 22(3): 212-217.
AMERICAN PSYCHIATRIC ASSOCIATION. Manual diagnóstico e estatístico de transtornos mentais: DSM-5-TR. 5. ed. rev. Porto Alegre: Artmed, 2022; 31p
ARENDT G. HIV-assoziierte neurokognitive Störungen. Nervenheilkunde, 2020; 39(09): 542-547.
BLOCH M, et al. A screening strategy for HIV-associated neurocognitive disorders that accurately identifies patients requiring neurological review. Clinical Infectious Diseases, 2016; 63(5): 687-693.
BRASIL. Ministério da Saúde. Protocolo Clínico e Diretrizes Terapêuticas para o Manejo da Infecção pelo HIV em Adultos: módulo 1. Brasília, DF: Ministério da Saúde, 2024. Disponível em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/aids/protocolo-clinico-e-diretrizes-terapeuticas-para-manejo-da-infeccao-pelo-hiv-em-adultos-modulo-1-tratamento/view. Acessado em: 02 de outubro de 2024.
BOONYAGARS L, et al. HIV-Associated Dementia: Associated Factors and Characteristics of Cognitive Domain Abnormalities in Elderly People Living with HIV Treated with Highly Active Antiretroviral Therapy. The American Journal of Tropical Medicine and Hygiene, 2022; 107(6): 1250-1257.
CARVALHO PP, et al. Factors associated with antiretroviral therapy adherence in adults: an integrative review of literature. Cien Saude Colet., 2019; 24(7): 2543-2555.
CAVALIER NT, et al. A relação entre inflamação crônica e desenvolvimento de doenças neurodegenerativas. Revista Ibero-Americana de Humanidades, Ciências e Educação, 2023; 9(7): 1744-1755.
EGOROVA EA, et al. A modern view on the prevention and treatment of HIV-associated neurocognitive disorders. Rossijskij Nevrologičeskij Žurnal, 2022; 27(5): 5-13.
GIL AC. Métodos e Técnicas de Pesquisa Social. 7. ed. São Paulo: Atlas, 2019.
HAZIOT MEJ, et al. Neuroimaging of HIV-associated neurocognitive disorders. Dementia & Neuropsychologia, 2015; 9(4): 380-384.
MACKIEWICZ MM, et al. Pathogenesis of age-related HIV neurodegeneration. Journal of NeuroVirology, 2019; 25(5): 622-633.
MEKURIAW B, et al. Prevalence and variability of HIV/AIDS-associated neurocognitive impairments in Africa: a systematic review and meta-analysis. BMC Public Health, 2023; 23: e997.
MOORE RC, et al. Smartphone-Based Measurement of Executive Function in Older Adults with and without HIV. Arch Clin Neuropsychol. 2020;35(4):347-357.
MWANGALA PN, et al. Screening tools for HIV-associated neurocognitive disorders among adults living with HIV in sub-Saharan Africa: A scoping review. AAS Open Research, 2019; 1: e28.
NIGHTINGALE S, et al. Moving on From HAND: Why We Need New Criteria for Cognitive Impairment in Persons Living With Human Immunodeficiency Virus and a Proposed Way Forward. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 2021; 73(6), 1113–1118.
ROBBINS RN, et al. A smartphone app to screen for HIV-related neurocognitive impairment. Journal of Mobile Technology in Medicine, 2014; 3(1): 23-26.
ROBBINS RN, et al. A mobile app to screen for neurocognitive impairment: preliminary validation of NeuroScreen among HIV-infected South African adults. JMIR Mhealth Uhealth, 2018; 6(1): e5.
RUBIN LH, et al. Tablet-based cognitive impairment screening for adults with HIV seeking clinical care: observational study. JMIR Mental Health, 2021; 8(9): e25660.
RODRIGUES RA, et al. Validity of the International HIV Dementia Scale in Brazil. Arquivos De Neuro-psiquiatria, 2013; 71(6): 376-379.
TAVARES JVM, et al. Desenvolvimento de aplicativo móvel para apoio no diagnóstico de HIV. Cadernos ESP, 2022; 16(2): 125-131.
TAVASOLI A, et al. Increasing Neuroinflammation Relates to Increasing Neurodegeneration in People with HIV. Viruses, 2023; 15(9): e1835.
VASTAG Z, et al. HIV-Associated Neurocognitive Disorder (HAND): Obstacles to Early Neuropsychological Diagnosis. Int J Gen Med. 2022 Apr 15; 15:4079-4090.
WAGSTAFF RA, et al. HIV associated neurocognitive disorder screening and diagnosis pathways in Australia: a scoping review and international implications. AIDS Care, 2024; 36(8): 1029-1040.
WANG Y, et al. Global prevalence and burden of HIV-associated neurocognitive disorder: a meta-analysis. Neurology, 2020; 95(19): e2610-e2621.
YECHOOR N, et al. Utility of a brief computerized battery to assess HIV-associated neurocognitive impairment in a resource-limited setting. J Neurovirol, 2016; 22(6): 808-815.
ZAEGEL-FAUCHER O, et al. Is the use of the QPC cognitive complaints questionnaire relevant for the screening strategy of HIV-Associated neurocognitive disorders? AIDS Care, 2021; 33(3): 389-397.
