Keywords
Hysterectomy
Ovarian function
AMH
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Abstract
Objective: To evaluate the impact of hysterectomy with salpingectomy on ovarian function and postoperative hormone levels. Methods: This is an integrative review, conducted in the Medline (PubMed) and Virtual Health Library (VHL) databases, including studies in the last 10 years, in Portuguese, English, and Spanish. Comparative studies, randomized controlled clinical trials, observational studies, meta-analyses, and systematic reviews addressing the effects of hysterectomy with or without salpingectomy on ovarian function were included. Results: 119 articles were identified in the PubMed and VHL databases, and 21 studies were selected after screening and full reading. These studies analyzed hysterectomized patients with or without salpingectomy and the relationship with outcomes in ovarian function, AMH, FSH, Luteinizing Hormone, and Inhibin B levels. Final considerations: Hysterectomy with salpingectomy appears to be a safe procedure regarding ovarian function in the short term, showing no significant hormonal changes in most studies. However, there is still evidence of possible reduction in ovarian reserve and anticipation of menopause in certain groups, especially when there is greater surgical manipulation. Thus, caution is recommended in performing the procedures, and studies with longer follow-up periods are needed to clarify the long-term effects and better guide practice.
References
ABDELAZIM IA, et al. Ovarian function and ovarian blood supply following premenopausal abdominal hysterectomy. Przegląd Menopauzalny, 2015; 14(1): 30–34.
ASGARI Z, et al. Comparing surgical outcome and ovarian reserve after laparoscopic hysterectomy between two methods of with and without prophylactic bilateral salpingectomy: A randomized controlled trial. J Câncer Res Ther, 2018; 14(3): 543-548.
ASKARY E, et al. Does laparoscopic hysterectomy + bilateral salpingectomy decrease the ovarian reserve more than total abdominal hysterectomy? A cohort study, measuring anti-Müllerian hormone before and after surgery. BMC Women’s Health, 2021; 21: art. 329.
ATALAY MA, et al. Change in the ovarian environment after hysterectomy with bilateral salpingectomy: is it the technique or surgery itself? European Journal of Obstetrics & Gynecology and Reproductive Biology, 2016; 204: 57-61.
BEHERY M, et al. Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstet Ginecologia Escand, 2017; 96(7): 795-803.
BEHERY M, et al. Impact of unilateral and bilateral salpingectomy on ovarian reserve. JBRA Assist Reprod, 2025.
BEREK JS e BEREK DL. Berek & Novak: tratado de ginecologia. 8ª ed. Rio de Janeiro: Guanabara Koogan, 2020.
BRASIL. Ministério da Saúde. Sistema de Informações Hospitalares do SUS (SIH/SUS). AIH aprovadas segundo região e procedimento. Brasília: Ministério da Saúde. Disponível em: http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sih/cnv/qiuf.def
CHABERT P, et al. What haemostatic technique should we use for opportunistic salpingectomy during benign laparoscopic hysterectomy? Gynécologie Obstétrique & Fertilité & Sénologie, 2017; 45(9): 453–459.
CHEN PC, et al. Possible association of hysterectomy accompanied with opportunistic salpingectomy with early menopause: a retrospective cohort study. Int J Environ Res Public Health, 2022; 19(19): 11871.
CHEN S, et al. Laparoscopic surgeries for uterine fibroids and ovarian cysts reduce ovarian reserve via age- and surgical type-manner. Gynecological Endocrinology, 2022; 38(12): 1068-1072.
CHO H, et al. Assessment of ovarian reserve after hysterectomy: Laparoscopic vs. non-laparoscopic surgery. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2017; 210: 54–57.
CHO HY e KYUNG MS. Comparison of Postoperative Ovarian Reserve Function Following Laparoscopic Hysterectomy and Laparoscopic Myomectomy: A Prospective Comparative Pilot Study. Journal of Clinical Medicine, 2021; 10(14): art. 3077.
CZUCZWAR P, et al. Comparison of the influence of three fibroid treatment options: supracervical hysterectomy, ulipristal acetate and uterine artery embolization on ovarian reserve– an observational study. Journal of Ovarian Research, 2018.
DALLEY AF e MOORE KL. Anatomia orientada para a clínica. 5. ed. Rio de Janeiro: Guanabara Koogan, 2007.
FERNANDES CE e POMPEI LM. Endocrinologia feminina. Barueri (SP): Manole, 2016.
GUPTA V, et al. Um estudo para avaliar o efeito da salpingectomia oportunista na reserva e função ovariana. Journal of Obstetrics and Gynaecology India, 2022; 73(1): 62–68.
HALL JE. Guyton & Hall: fundamentos de fisiologia. 14. ed. Rio de Janeiro: Elsevier, 2021
HUANG Y, et al. Effect of hysterectomy on ovarian function: a systematic review and meta-analysis. Journal of Ovarian Research, 2023.
HONGSAKORN W, et al. The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial. British Journal of Nutrition, 2025; 133(2): 213–220.
RADU T, et al. The impact of opportunistic salpingectomy on ovarian reserve: a systematic review. Journal of Clinical Medicine, 2024; 13(11): 3296.
SONG T, et al. Impact of opportunistic salpingectomy on anti-Müllerian hormone in patients undergoing laparoscopic hysterectomy: a multicentre randomised controlled trial. BJOG: An International Journal of Obstetrics & Gynaecology, 2016; 124(2): 314-320.
TEHRANIAN A, et al. Effects of salpingectomy during abdominal hysterectomy on ovarian reserve: a randomized controlled trial. Gynecological Surgery, 2017; 14(1): 17.
VAHEDPOUR Z, et al. Os efeitos da salpingectomia no nível sérico do hormônio anti-Mülleriano: um estudo controlado randomizado simples-cego. Journal of Gynecology Obstetrics and Human Reproduction, 2020; 49(3): 101658.
VENTURELLA R, et al. 3 to 5 years later: long-term effects of prophylactic bilateral salpingectomy on ovarian function. Journal of Minimally Invasive Gynecology, 2017; 24(1): 145-150.
YUAN Z, et al. The effects of hysterectomy with bilateral salpingectomy on ovarian reserve. International Journal of Gynaecology and Obstetrics, 2019; 145(2): 233-238.