Abstract
Objective: To report a rare case of neurocriptococcosis in a immunocompetent patient. Case report: The infection of the central nervous system by the fungus Cryptococcus neoformans, also called neurocriptococcosis, is a rare disorder more common in people who have some degree of immune impairment, whether primary or secondary, acting as an opportunistic infection. We describe a case of an immunocompetent patient with laboratory findings compatible with neurocriptococcosis who presented only with migraine headache, isolated pulmonary nodule without clinical complaints and nonspecific central nervous system imaging. Final considerations: In immunocompetent patients, fungal infections are rare and may present with non-evident symptoms, making the etiological diagnosis difficult. Thorough medical history associated with complementary tests well used is necessary in order to arrive at the etiological diagnosis as safely as possible to ensure the correct therapy. In addition, it is necessary to employ the fastest techniques and obtain diagnosis, as well as for screening, since these patients are oligosymptomatic and benefit from early treatment.