Abstract
Objective: Review the relationship between creatine supplementation, especially in its monohydrate form, and the decline in renal function, as well as whether there is a relationship between this supplementation and kidney injury. Bibliographic review: The findings of renal injury associated with the use of creatine could not attribute the clinical picture in isolation to the use of the substance. It should be considered that individual characteristics, as well as food consumption and other supplements, play an important role. The use of creatine in recommended doses has its safety guaranteed by regulatory agencies and there is no contraindication for its use by healthy people and those in need of supplementation so far. Final considerations: When analyzing the use of creatine alone and as the only triggering factor for kidney injury, insufficient evidence was found to consolidate the association between kidney dysfunction and the use of this substance. The use of creatine is safe for healthy people, when in adequate doses.