Abstract
Objective: Review the use of ozone therapy in Dentistry to publicize current clinical applications and encourage scientific research on the subject. Methods: The integrative review was carried out on articles published until February 2021 which were available in the Biblioteca Virtual em Saúde (BVS) online database and the PubMed online database. The uniterms ozone, ozone therapy, health and Dentistry were used in combination through the “ozone AND ozone therapy AND health AND Dentistry” and “ozone AND Dentistry” strategies. Articles published in free full text from 2016 to 2021, in Portuguese and in English, were included. Results: Ozone therapy is used in Dentistry as an adjunct in the control of biofilms and post-surgical pain; in the treatment of dental caries, dentin hypersensitivity, oral lichen planus, gingivitis, periodontitis, osteomyelitis, osteonecrosis, halitosis, and temporomandibular joint disorder; as well as in wound healing; in endodontic treatment and tooth whitening. Final considerations: Ozone therapy is reaffirming itself as a promising preventive and therapeutic approach with wide application in Dentistry. The importance of continuing studies on the applicability and effectiveness of ozone is emphasized, including to understand its interference with the oral microbiome and systemic homeostasis.