Abstract
Objective: To identify the presence of drug interactions in patients with renal disorder at a reference hospital in Brazilian Northeast and to verify the frequency and severity of these interactions. Methods: This is a descriptive field study, based on analysis of the medical prescriptions in patients with renal disorders in which all the medical prescriptions of patients admitted in Nephrology Clinic were observed during December 2018 and January 2019. The information obtained was analyzed using the database Drugs.com and summarized using to statistical analysis. Results: Of the 329 prescriptions analyzed, 82.98% had drug interactions, 12.38% were classified as minor interactions, 75.97% moderate interactions and 11.65% major interactions. The drug interaction between Anlodipine and Enalapril (14.89%) was the most frequent among the minor interactions. The predominant moderate interactions were: Furosemide and Prednisone (31%), Amlodipine and Prednisone (30.40%). While in the interactions classified as major, Anlodipine and Simvastatin (20.97%), Atenolol and Clonidine (10.33%) prevailed. Conclusion: The high rate of drugs interaction in the Nephrology Clinic is perceptible, and so it is therefore necessary to remember the real importance of including the pharmacist in the multiprofessional team in order to ensure therapeutic success of the patient.