Palabras clave
Vitamina D
Depresión
Cómo citar
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Resumen
Objetivo: Analizar los principales artículos científicos de la literatura médica sobre la influencia de la microbiota intestinal y la vitamina D en la depresión. Métodos: Revisión integrativa de la literatura mediante búsquedas, en los últimos 5 años (2019 – 2024), realizadas en las bases de datos: Scielo, PubMed, Literatura Latinoamericana y del Caribe (LILACS) y MEDLINE indexadas en la Biblioteca Virtual en Salud (BVS). Se utilizaron los siguientes operadores booleanos: “microbiota intestinal” Y “depresión”, “vitamina D” Y “depresión” y “microbiota intestinal” Y “vitamina D”. Resultados: Mostramos en el foro final 26, todos de PubMed, 13 artículos abordan microbiota intestinal y depresión, 8 artículos sobre microbiota intestinal y vitamina D y 5 artículos sobre vitamina D y depresión. Consideraciones finales: La investigación analizada destacó la compleja relación entre la microbiota intestinal y la vitamina D en la depresión. Comprender los mecanismos que existen en esta relación ofrece nuevas estrategias para tratar este trastorno debilitante más allá de los síntomas emocionales.
Referencias
AGGELETOPOULOU I, et al. 2023. Exploring the Role of Vitamin D and the Vitamin D Receptor in the Composition of the Gut Microbiota. Frontiers in Bioscience (Landmark Edition), 2023; 28(6): 116.
AKIMBEKOV I, et al. Vitamin D and the Host-Gut Microbiome: A Brief Overview, Acta Histochemica et Cytochemica, 2020; 53(3): 33–42.
BEUREL E, et al. The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron, 2020; 107(2): 234–56.
BELLERBA F, et al. The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies. Nutrients, 2021; 13(10): 3378.
CAI Y, et al. Gut-brain axis in depression: Crosstalk between neuroinflammation and gut microbiota. Advanced Neurology, 2023;1(3): 272.
CANTORNA MT, et al. Vitamin A and vitamin D regulate the microbial complexity, barrier function and the mucosal immune responses to insure intestinal homeostasis. Critical reviews in biochemistry and molecular biology, 2019; 54(2): 184–192.
CHATTERJEE I, et al. Vitamin D Receptor Promotes Healthy Microbial Metabolites and Microbiome. Scientific Reports, 2020; 10(1): 7340.
CROLL PH, et al. Associations of Vitamin D Deficiency with MRI Markers of Brain Health in a Community Sample, Clinical Nutrition, 2021; 40(1): 72–78.
CRUZ-PEREIRA JS, et al. Depression’s Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome. Annual Review of Psychology, 2020; 71(1): 49–78.
DUDEK KA, et al. Neurobiology of Resilience in Depression: Immune and Vascular Insights from Human and Animal Studies. The European Journal of Neuroscience, 2021; 53(1): 183–221.
GENG C, et al. Vitamin D and Depression: Mechanisms, Determination and Application, Asia Pacific Journal of Clinical Nutrition, 2019; 28(4): 689–694.
GÓRALCZYK-BIŃKOWSKA A, et al. The Microbiota-Gut-Brain Axis in Psychiatric Disorders. International Journal of Molecular Sciences, 2022; 23(19): 11245.
KOUBA BR, et al. Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety. International Journal of Molecular Sciences, 2022; 23(13): 7077.
MADAN A, et al. The Gut Microbiota Is Associated with Psychiatric Symptom Severity and Treatment Outcome among Individuals with Serious Mental Illness. Journal of Affective Disorders, 2020; 264: 98–106.
MAYNE PE e BURNE TH. Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness. Trends in Neurosciences, 2019; 42(4): 293–306.
MCGUINNESS AJ, et al. A Systematic Review of Gut Microbiota Composition in Observational Studies of Major Depressive Disorder, Bipolar Disorder and Schizophrenia. Molecular Psychiatry, 2022; 27(4): 1920–1935.
MUSAZADEH V, et al. Vitamin D Protects against Depression: Evidence from an Umbrella Meta-Analysis on Interventional and Observational Meta-Analyses. Pharmacological Research, 2023; 187: 106605.
OTAKA M, et al. Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota. Microorganisms, 2021; 9(5): 1026.
PORTO CM, et al. Contribuições da vitamina D no tratamento de sintomas depressivos e fatores de risco cardiovascular: protocolo de estudo para um ensaio clínico randomizado, duplo-cego e controlado por placebo. Trials, 2019; 20: 583.
RUTSCH A, et al. The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Frontiers in Immunology, 2020; 11: 604179.
SANADA K, et al. Gut Microbiota and Major Depressive Disorder: A Systematic Review and Meta-Analysis. Journal of Affective Disorders, 2020; 266: 1–13.
SHIEH A, et al. Pilot Trial of Vitamin D3 and Calcifediol in Healthy Vitamin D Deficient Adults: Does It Change the Fecal Microbiome? Journal of Clinical Endocrinology and Metabolic, 2021; 106(12): 3464–76.
SINGH P, et al. The Potential Role of Vitamin D Supplementation as a Gut Microbiota Modifier in Healthy Individuals. Scientific Reports, 2020; 10(1): 21641.
SMITH DG, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology, 2019; 236(5): 1653–70.
TANELIAN A, et al. Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns. Biology of Sex Differences, 2024; 15(1): 20.
TANGESTANI H, et al. Vitamin D and The Gut Microbiota: A Narrative Literature Review. Clinical Nutrition Research, 2021; 10(3): 181–191.