Palabras clave
Biomarcadores
Progresión de la Enfermedad
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Resumen
Objetivo: Explorar los avances más recientes en biomarcadores pronósticos de la Anemia Falciforme (AF). Métodos: La búsqueda se realizó en PubMed Central con artículos en inglés publicados entre los años 2020 y 2024. Tras la selección de títulos y resúmenes, se eligieron artículos experimentales que abordaban la temática a partir de los descriptores “biomarkers” y “Sickle Cell Anemia”. Se excluyeron de la investigación las revisiones de literatura, cartas al editor, editoriales, libros, capítulos de libros, informes de casos o cualquier otro artículo que no se ajustara al propósito del estudio o estuviera fuera del período estipulado.Resultados: Se identificaron 212 artículos, pero solo 26 cumplieron con todos los criterios de inclusión. Los biomarcadores encontrados en el estudio fueron: cf-mtDNA, sE-selectina, dilatación mediada por el flujo de la arteria braquial, flujo sanguíneo cerebral, viscosidad sanguínea total, PON1, IL-6, miR-199a-5p y miR-144, SOD2V16A, cortisol capilar, PLSCR4, NRG-1β, gen TGFBR3, uNGAL, Copeptina, entre otros.Consideraciones finales: Estos hallazgos pueden abrir caminos para el desarrollo de estudios que contribuyan a mejorar el seguimiento y manejo clínico de la AF; sin embargo, se necesitan más investigaciones para validar su utilidad clínica.
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