Palabras clave
Medicina herbaria
Desnutrición proteica
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Resumen
Objetivo: Sintetizar la evidencia sobre los efectos del cannabidiol (CBD), un compuesto no psicoactivo de Cannabis sativa L., como posible estrategia terapéutica para mitigar las alteraciones fisiológicas derivadas de la restricción proteica. Revisión bibliográfica: La ingesta insuficiente de proteínas es un problema global que compromete la integridad funcional de los órganos implicados en la digestión y el metabolismo, como el hígado y el páncreas. La restricción proteica altera la síntesis proteica, altera el metabolismo hepático, promueve procesos inflamatorios y puede desencadenar disbiosis intestinal. Paralelamente, los derivados de Cannabis sativa, como el CBD, han demostrado propiedades antiinflamatorias, antioxidantes y moduladoras del sistema endocannabinoide; este sistema se expresa ampliamente en el hígado y el intestino. La evidencia experimental indica que el CBD puede regular las vías de señalización metabólica, reducir el estrés oxidativo, atenuar la inflamación intestinal y contribuir al equilibrio de la barrera epitelial, aspectos frecuentemente comprometidos en situaciones de restricción proteica. Consideraciones finales: Los hallazgos disponibles sugieren que el cannabidiol tiene potencial terapéutico como modulador de las alteraciones metabólicas y gastrointestinales inducidas por la restricción proteica. Sin embargo, se necesitan más estudios para consolidar su aplicabilidad clínica y definir dosis, mecanismos de acción y seguridad a largo plazo.
Referencias
AGOSTON DV. How to Translate Time? The Temporal Aspect of Human and Rodent Biology. Frontiers in neurology, 2017; 8: 92.
ANDREWS KW, et al. Dietary Supplement Ingredient Database (DSID) and the Application of Analytically Based Estimates of Ingredient Amount to Intake Calculations. The Journal of nutrition, 2018; 1413S–1421S.
BANNITZ RF. Estudo das alterações metabólicas e moleculares envolvidas na restrição calórica e na dieta hipoproteica em seres humanos - Tese (Doutorado). Universidade de São Paulo, Ribeirão Preto, 2021.
BERUMEN J, et al. Liver fibrosis: Pathophysiology and clinical implications. WIREs mechanisms of disease, 2021; 13(1): e1499.
BROWN K, et al. The Modulatory Effects and Therapeutic Potential of Cannabidiol in the Gut. Cells, 2024; 13(19): 1618.
BOROWSKA M, et al. The effects of cannabinoids on the endocrine system. Endokrynologia Polska, 2018; 69(6): 705–719.
CHAVATTE-PALMER, P et al. Dieta antes e durante a gravidez e saúde da prole: a importância dos modelos animais e o que pode ser aprendido com eles. International Journal of Environmental Research and Public Health, 2016; 13(6): 586.
CHEN S e KIM JK. The Role of Cannabidiol in Liver Disease: A Systemic Review. International journal of molecular sciences, 2024; 25(4): 2370.
DUAN J, et al. Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics. Frontiers in microbiology, 2023; 14: 1231372.
EITAN A, et al. The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice. International journal of molecular sciences, 2023; 24(18): 13797.
FALLAHI S, et al. Hemp in Animal Diets-Cannabidiol. Animals: an open access journal from MDPI, 2022; 12(19), 2541.
FARINON B, et al. The seed of industrial hemp (Cannabis sativa L.): Nutritional Quality and Potential Functionality for Human Health and Nutrition. Nutrients, 2020; 12(7): 1935.
FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS. FAO, 2019. Available from: http://www.fao.org. Acessado: 18 de fevereiro de 2025.
FORGIE AJ, et al. The impact of maternal and early life malnutrition on health: a diet-microbe perspective. BMC medicine, 2020; 18(1): 135.
GOMES HMS. Pirâmide De Alimentos: Guia Para Alimentação Saudável. Boletim Técnico IFTM, 2016; 10-15.
GOMES CC. Efeitos terapêuticos e não terapêuticos de Cannabis sativa L. (Tese de Doutorado). Universidade de Algarve, Portugal, 2021.
GONTIJO ÉC, et al. Canabidiol e suas aplicações terapêuticas. Revista Eletrônica Da Faculdade de Ceres, 2016; 5(1).
HOUSE JD, et al. Evaluating the quality of protein from hemp seed (Cannabis sativa L.) products through the use of the protein digestibility-corrected amino acid score method. Journal of agricultural and food chemistry, 2010; 58(22): 11801–11807.
HERTZLER SR, et al. Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function. Nutrients, 2020; 12(12): 3704.
KIM JH, et al. In Vitro and In Vivo Anti-Inflammatory Effects of Cannabidiol Isolated from Novel Hemp (Cannabis sativa L.) Cultivar Pink Pepper. Molecules (Basel, Switzerland), 2023; 28(18): 6439.
KLEIN JL, et al. Efeitos da nutrição materna na gestação sobre a qualidade da progênie - uma revisão. Development, 2021; 10(2): e45710212654.
KORUS J, et al. Hemp (Cannabis sativa subsp. sativa) flour and protein preparation as natural nutrients and structure forming agents in starch based gluten-free bread. LWT, 2017; 84: 143–150.
LEE Y, et al. Cannabidiol Loaded Nanoemulsion with Improved Bioaccessibility and Anti-Inflammatory Activity. ACS Omega, 2025; 10(41): 48146–48154.
MA R, et al. Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating NF-κB and PPAR- α pathways. Experimental biology and medicine (Maywood, N.J.), 2024; 249: 10141.
MACCARRONE M, et al. Endocannabinoid signaling at the periphery: 50 years after THC. Trends in pharmacological sciences, 2015; 36(5): 277–296.
MCPARTLAND JM, et al. Cannabis is indigenous to Europe and cultivation began during the Copper or Bronze age: a probabilistic synthesis of fossil pollen studies. Vegetation History and Archaeobotany, 2018; 27(4): 635–648.
NASCIMENTO-JÚNIOR BJD. Anatomia humana sistemática básica, UNIVASF, 2020.
PACHECO-GÓMEZ V, et al. Bioquímica e vias metabólicas de polissacarídeos, lípidos e proteínas. Abanico veterinário , 2021; v. 11.
PALLADINO E, et al. Diet Alters Micronutrient Pathways in the Gut and Placenta that Regulate Fetal Growth and Development in Pregnant Mice. Reproductive sciences (Thousand Oaks, Calif.), 2021; 28(2): 447–461.
PAVLOVIC R, et al. Phytochemical and Ecological Analysis of Two Varieties of Hemp (Cannabis sativa L.) Grown in a Mountain Environment of Italian Alps. Frontiers in plant science, 2019; 10: 1265.
RIBEIRO MLS. A influência da alimentação materna no desenvolvimento fetal. 2024
SANTARPIA L., et al. Nutritional screening and early treatment of malnutrition in cancer patients. Journal of cachexia, sarcopenia and muscle, 2011; 2(1): 27–35.
STORY G, et al. Cannabidiol and Intestinal Motility: a Systematic Review. Current developments in nutrition, 2023; 7(10), 101972.
TAHA IE, et al. Enhancement of cannabidiol oral bioavailability through the development of nanostructured lipid carriers: In vitro and in vivo evaluation studies. Drug delivery and translational research, 2025; 15(8): 2722–2732.
TREFTS E, et al. The liver. Current biology: CB, 2017; 27(21): R1147–R1151.
VUČKOVIĆ S, et al. Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in pharmacology, 2018; 9: 1259.
WANG Y, et al. Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. Scientific reports, 2017; 7(1): 12064.
WEISS SRB, et al. Building smart cannabis policy from the science up. International Journal of Drug Policy, 2017; 42: 39–49.
XIONG S, al. Global research trends on inflammatory bowel diseases and colorectal cancer: A bibliometric and visualized study from 2012 to 2021. Frontiers in Oncology, 2022; 12.
ZOU S, KUMAR U. Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. International Journal of Molecular Sciences, 2018; 19(3): 833.