Abstract
Objective: To analyze whether the site where the DBS device is inserted effectively interferes with the complications of Parkinson's disease. Methods: A search was performed on the digital platforms VHL and PubMed with the descriptors: Parkinson's disease and deep brain stimulation. The inclusion criteria were full articles, published in the last 6 years (2016-2022), in English and of the controlled clinical study type. Duplicate articles and those that deviate from the topic addressed were excluded, resulting in a total of 28 papers. Results: It was observed that the manifestations of PD (whether motor or non-motor) were improved, in their majority, from the DBS. Adverse effects were observed, which even demanded the need to change the therapeutic target of DBS in some cases. Depression was one of the main symptoms that showed no improvement after the surgical procedure. Final considerations: In this way, it can be considered that there was improvement of motor and non-motor symptoms in patients with Parkinson's disease, after deep brain stimulation, which could demonstrate the effectiveness of the procedure. The nucleus approached that obtained the greatest efficacy was the subthalamic nucleus. Depression and anxiety did not improve after DBS.
References
BARBE MT, et al. Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease With Early Motor Complications. Movement Disorders, 2019; 35(1): 82–90.
BEITZ JM. Parkinson 's disease: a review. Frontiers in Bioscience (FBS), 2014; S6(1): 65–74.
BELASEN A, et al. Effect of low-frequency deep brain stimulation on sensory thresholds in Parkinson’s disease. Journal of Neurosurgery, 2017; 126(2): 397–403.
BERNARDO WM, et al. Deep brain stimulation in parkinson disease. Revista da Associação Médica Brasileira, 2019; 65(4): 541–6.
BLOMSTEDT P, et al. Deep brain stimulation in the caudal zona incerta versus best medical treatment in patients with Parkinson’s disease: a randomized blinded evaluation. Journal of Neurology, Neurosurgery & Psychiatry, 2018; 89(7): 710–6.
CELIKER O, et al. Comparison of subthalamic nucleus vs. globus pallidus interna deep brain stimulation in terms of gait and balance; a two year follow-up study. Turkish Neurosurgery, 2019; 29(3): 355-361.
CONWAY ZJ, et al. Low-frequency STN-DBS provides acute gait improvements in Parkinson’s disease: a double-blinded randomized cross-over feasibility trial. Journal of Neuroengineering and Rehabilitation, 2021; 18(1): 125.
DAFSARI HS, et al. Beneficial Effects of Bilateral Subthalamic Stimulation on Non-Motor Symptoms in Parkinson 's Disease. Brain Stimulation, 2016; 9(1): 78–85.
DAFSARI HS, et al. Quality of life outcome after subthalamic stimulation in Parkinson’s disease depends on age. Movement Disorders, 2017; 33(1): 99–107.
DAFSARI HS, et al. Nonmotor symptoms evolution during 24 months of bilateral subthalamic stimulation in Parkinson 's disease. Movement Disorders, 2018; 33(3): 421–30.
DOSHI PK, et al. Depressão que levou à tentativa de suicídio após estimulação do núcleo subtalâmico bilateral para a doença de Parkinson. Mov Disord., 2002; 17: 1084-5.
GRATWICKE J, et al. Bilateral Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia: A Randomized Clinical Trial. JAMA neurology, 2018; 75(2): 169–78.
GOULART F e PEREIRA LX. Uso de escalas para avaliação da doença de Parkinson em fisioterapia. Fisioter Pesq., 2005; 11(1): 49-56.
HAYES MT. Parkinson 's Disease and Parkinsonism. AMJ, 2019; 132(7): 802–7.
HOGG E, et al. Sustained quality-of-life improvements over 10 years after deep brain stimulation for dystonia. Movement Disorders, 2018; 33(7): 1160–7.
IRMEN F, et al. Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms. Annals of Neurology, 2020; 87(6): 962–75.
JOST ST, et al. Subthalamic Stimulation Improves Quality of Sleep in Parkinson Disease: A 36-Month Controlled Study. JPD, 2021; 11(1): 323–35.
JOST ST, et al. A prospective, controlled study of non-motor effects of subthalamic stimulation in Parkinson’s disease: results at the 36-month follow-up. Journal of Neurology, Neurosurgery, and Psychiatry, 2020; 91(7): 687–94.
LISTIK C, et al. Deep brain stimulation treatment in dystonia: a bibliometric analysis. Arquivos de Neuro-Psiquiatria, 2020; 78(9): 586–92.
MANSOURI A, et al. Deep brain stimulation for Parkinson’s disease: meta-analysis of results of randomized trials at varying lengths of follow-up. JNS, 2018; 128(4): 1199–213.
MEROLA A, et al. Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry. Movement Disorders, 2017; 32(8): 1240–4.
MESTRE TA, et al. Long-term double-blinded unilateral pedunculopontine area stimulation in Parkinson 's disease. Movement Disorders, 2016; 31(10): 1570–4.
ODEKERKEN VJJ, et al. GPi vs STN deep brain stimulation for Parkinson disease. Neurology, 2016; 86(8): 755–61.
PFLUG C, et al. Impact of simultaneous subthalamic and nigral stimulation on dysphagia in Parkinson 's disease. Annals of Clinical and Translational Neurology, 2020; 7(5): 628–38.
PRINGSHEIM T, et al The prevalence of Parkinson’s disease: A systematic review and meta-analysis. Movement Disorders, 2014; 29(13): 1583–90.
TOMLINSON CL, et al. Physiotherapy intervention in Parkinson’s disease: systematic review and meta-analysis. BMJ, 2012; 345: e5004–4.
TRÖSTER AI, et al. Neuropsychological outcomes from constant current deep brain stimulation for Parkinson’s disease. Movement Disorders, 2016; 32(3): 433–40.
WITTE LP, et al. Does deep brain stimulation improve lower urinary tract symptoms in Parkinson 's disease? Neurourology and Urodynamics, 2018; 37(1): 354–9.
XIE T, et al. Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD. Journal of Neurology, Neurosurgery, and Psychiatry, 2018; 89(9): 989–94.
ZHAO N, et al. Quality of life in Parkinson 's disease: A systematic review and meta‐analysis of comparative studies. CNS Neuroscience & Therapeutics, 2020; 27(3): 270–9.
