Abstract
Objective: Analyze the mutual influence between breast cancer treatment and mental disorders in elderly patients. Methods: This is an integrative review, in which scientific articles published in the last 5 years (2018-2023) were selected from the PubMed, Scopus and BVS databases, using the descriptors “aged women”, “treatment”, “breast cancer” and “mental disorders”. The careful integrative search resulted in one 1400 articles. After applying the eligibility criteria, 20 studies were included. Results : The articles found were divided into two groups: the first group evaluated an increase in the prevalence of depression and anxiety and a negative impact on cognitive function in patients undergoing breast cancer treatment; In the second group, mental disorders were associated with increased mortality from breast cancer and worse disease outcomes (increased hospitalization time and risk of post-surgical infections), with an association of psychiatric drugs with increased risk of emergence of breast cancer. Final considerations: The mutual influence between breast cancer treatment and mental disorders in elderly patients is evident, generally presenting bilaterally negative impacts.
References
AHLGRÉN-RIMPILÄINEN AJ, et al. Excess mortality from breast cancer in female breast cancer patients with severe mental illness. Psychiatry research, 2020; 286; 112801: 112801.
ÁLVAREZ-PARDO S, et al. Related factors with depression and anxiety in mastectomized women breast cancer survivors. International journal of environmental research and public health, 2023; 20: 4.
BEDILLION MF, et al. A Cancer treatment effects on cognition and depression: The moderating role of physical activity. Breast (Edinburgh, Scotland), 2019; 44: 73–80.
BLANCHETTE PS, et al. The association between endocrine therapy use and dementia among post-menopausal women treated for early-stage breast cancer in Ontario, Canada. Journal of geriatric oncology, 2020; 11; 7: 1132–1137.
BREIDENBACH C, et al. Prevalence and determinants of anxiety and depression in long-term breast cancer survivors. BMC psychiatry, 2022; 22; 1: 101.
BUSCARIOLLO DL, et al. Impact of pre-diagnosis depressive symptoms and health-related quality of life on treatment choice for ductal carcinoma in situ and stage I breast cancer in older women. Breast Cancer Research and Treatment, 2018; 173: 709-717.
CARREIRA H, et al. Associations between breast cancer survivorship and adverse mental health outcomes: A matched population-based cohort study in the United Kingdom. PLoS medicine, 2021; 18: 1003504.
CHU RYK, et al. Breast cancer risks following antipsychotic use in women with bipolar disorder versus schizophrenia: A territory-wide nested case-control study spanning two decades. Psychiatry research, 2023; 326: 115287.
DALTON SO, et al. Impact of schizophrenia and related disorders on mortality from breast cancer: A population-based cohort study in Denmark, 1995-2011. Breast (Edinburgh, Scotland), 2018; 40: 170–176.
DESHPANDE AJ, et al. Examining the relationship between severe persistent mental illness and surgical outcomes in women undergoing mastectomy for breast cancer. American journal of surgery, 2023; 226; 1: 4–10.
FOND G, et al. End of life breast cancer care in women with severe mental illnesses. Scientific reports, 2021;11: 10167.
GUIMOND A-J, et al. Clusters of psychological symptoms in breast cancer: Is there a common psychological mechanism? Cancer nursing, 2020; 43: 343–353.
HASKINS CB, et al. Impact of preexisting mental illness on breast cancer endocrine therapy adherence. Breast cancer research and treatment, 2019; 174: 197–20
HASKINS CB, et al. Effects of previous medication regimen factors and bipolar and psychotic disorders on breast cancer endocrine therapy adherence. Clinical breast cancer, 2020; 20 e261–e280.
HORMOZI M, et al. Investigating relationship between pre- and post- chemotherapy cognitive performance with levels of depression and anxiety in breast cancer patients: A cross-sectional study. Asian Pacific journal of cancer prevention: APJCP, 2019; 20: 3831–3837
JOMAR RT, et al. Fatores associados ao tempo para submissão ao primeiro tratamento do câncer de mama. Ciência & Saúde Coletiva, 2023; 28: 2155–2164.
LEAL FR, et al. Prevalência de depressão e ansiedade e sua relação com esperança em pacientes oncológicos em tratamento quimioterápico. rmmg.org, 2021; 31: 61–66.
MARTIN C, et al. Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study. Journal of geriatric oncology, 2021; 12; 5: 705–713.
MARTIN C, et al. Caregiver experiences of making treatment decisions for older women with breast cancer and dementia. Health & social care in the community, 2022; 30; 5: e2058–e2068.
MONTILLA D, et al. Mortalidade por câncer de mama em mulheres idosas no Brasil e nas grandes regiões: uso do SISAP-Idoso. Reciis, 2023; 17: 372–386.
PIROTH MD, et al. Anxiety and depression in patients with breast cancer undergoing radiotherapy: the role of intelligence, life history, and social support-preliminary results from a monocentric analysis. Strahlentherapie Und Onkologie: Organ Der Deutschen Rontgengesellschaft. 2022; 198; 4; 388–396.
SHEN Q, et al. Psychiatric disorders and cardiovascular diseases during the diagnostic workup of potential breast cancer: a population-based cohort study in Skåne, Sweden. Breast cancer research: BCR, 2019; 21: 139.
TAIPALE H, et al. Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland. The lancet. Psychiatry, 2021; 8: 883–891.
