Arquivos suplementares
Palavras-chave
Carcinoma de Ehrlich
Histopatologia
Química medicinal
Toxicidade
Como Citar
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Resumo
Objetivo: Determinar a toxicidade do derivado sintético 2-N-glicina-1, estruturalmente relacionado à 4-naftoquinona lapachol, em camundongos machos Swiss após administração oral deste composto. Métodos: O tumor de Ehrlich foi implantado no tecido subcutâneo da região axilar direita em camundongos machos Swiss de 8 semanas de idade, e a célula tumoral foi mantida sob forma ascítica. Os tratamentos começaram no 3º dia após a implantação da célula tumoral e a avaliação biométrica foi realizada diariamente até o 8º dia. Microesteatose e necrose da coagulação hepática, espessamento da cápsula de Bowman e necrose do túbulo renal foram mais graves com 1000 ou 4000 μg/kg. Resultados: Em geral, a taxa mais efetiva de inibição do tumor foi observada em animais tratados com 40 μg/kg do composto, com uma redução de % variando de 90 a 96% em comparação aos controles. A naftoquinona não exibiu um efeito anticancerígeno dependente da dose. No entanto, alterações histopatológicas significativas foram encontradas de forma dose-dependente, especialmente no fígado, rins, coração e baço, bem como diminuição do hematócrito. Conclusão: Os dados demonstram que, embora a naftoquinona tenha promovido redução tumoral significativa na dose de 40 μg/kg, isso foi acompanhado por toxicidade dose-dependente acentuada no fígado, rins e coração.
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