Keywords
Neurodegenerative diseases
Medical cannabis
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Abstract
Objective: To analyze the effects of cannabinoids in the treatment and/or relief of symptoms of neurodegenerative diseases, such as: Parkinson's, Alzheimer's Disease and Multiple Sclerosis. Methods: An integrative review was carried out with the aim of compiling the main results of the use of cannabinoids in the prevention and control of neurodegenerative diseases with a focus on Parkinson's, Alzheimer's and Multiple Sclerosis diseases. Scientific articles available on the Periódicos Capes portal distributed in the PubMed, Science Direct and Medline databases were selected. Results: 331 scientific articles were found, filtered only by clinical trials. After screening, 52 full texts were read and 21 articles were selected for this review. The selected articles demonstrate positive results in improving symptoms and general quality of life in all pathologies. Most of the studies were carried out in European countries, demonstrating the need for greater investment in clinical research with cannabinoids, mainly in South America. Final considerations: With the analysis of the texts, it is possible to conclude that the cannabinoids Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are beneficial compounds in clinical trials with positive results in controlling and preventing symptoms of the three neurodegenerative diseases chosen for this review.
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