Palabras clave
Cause of death
Risk factors
Hospitalization
Adult
Logistic regression
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Resumen
Objetivo: Analizar los factores de riesgo asociados a la muerte de pacientes adultos hospitalizados con SIDA en un hospital de referencia. Métodos: Estudio transversal que involucró a pacientes mayores de 18 años, de ambos sexos, hospitalizados con SIDA en el año 2019. Se evaluaron el desenlace de muerte y las variables explicativas categorizadas en aspectos sociodemográficos, clínicos y específicos del VIH. La asociación entre los factores de riesgo y el desenlace se probó mediante regresión logística. Resultados: De los 116 pacientes involucrados en este estudio, la edad (OR: 1,1188 IC 95% [1,0461;1,2170], p=0,0030) y las infecciones oportunistas (OR: 10,0377 IC 95% [1,9426-75,2189], p=0,0111) fueron factores de riesgo para la muerte. Las variables de adhesión a la terapia (OR: 0,9290 IC 95% [0,8958-0,9539], p < 0,001) y los niveles de Linfocitos T-CD4+ entre 50 y 100 células/mm³ (OR: 0,4804 IC 95% [0,0612-3,7268], p=0,0323) fueron factores de protección contra la muerte. Conclusión: Por cada año de edad, el riesgo de muerte aumentó en un 11,8%, y fue aproximadamente diez veces mayor en la presencia de alguna infección oportunista. El riesgo de muerte disminuyó en un 7,1% cuando el paciente presentaba buena adhesión al tratamiento y en aproximadamente un 90,8% con Linfocitos T-CD4+ entre 50 y 100 células/mm³.
Referencias
BEKKER LG, et al. HIV infection. Revista Eletrônica Acervo Saúde, 2023; 9(1): e00452-3.
BRASIL. Protocolo clínico de diretrizes terapêuticas para manejo da infecção pelo HIV em adultos. Revista Eletrônica Acervo Saúde, 2018; 12(1): e2987. Disponível em: https://www.gov.br/aids/pt-br/central-de-conteudo/pcdts/2013/hiv-aids/pcdt_manejo_adulto_12_2018_web.pdf/view
CAI C, et al. Analysis on death trend in AIDS patients and related risk factors in China. Revista Eletrônica Acervo Saúde, 2021; 42(1): e01169.
CAIXETA AKS, et al. People living with HIV/AIDS in southwest Goiás: sociodemographic, clinical and laboratory characterization in the year 2018. Revista Eletrônica Acervo Saúde, 2023; 102(1): e195987.
CHIMBETETE C, et al. Mortality trends and causes of death among HIV positive patients at Newlands Clinic in Harare, Zimbabwe. Revista Eletrônica Acervo Saúde, 2020; 15(8): e0237904.
CUNHA AP, et al. Analysis of the trend of mortality from HIV/AIDS according to sociodemographic characteristics in Brazil, 2000 to 2018. Revista Eletrônica Acervo Saúde, 2022; 27(3): e00432.
EHRENKRANZ PD, et al. The missed potential of CD4 and viral load testing to improve clinical outcomes for people living with HIV in lower-resource settings. Revista Eletrônica Acervo Saúde, 2019; 16(5): e1002820.
ERLANDSON KM, KARRIS MY. HIV and Aging: Reconsidering the Approach to Management of Comorbidities. Revista Eletrônica Acervo Saúde, 2019; 33(3): e769-786.
FRIJTERS EM, et al. Risk factors for loss to follow-up from antiretroviral therapy programmes in low-income and middle-income countries. Revista Eletrônica Acervo Saúde, 2020; 34(9): e1261-88.
GAILET A, et al. Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the outcomes a multicenter cohort. Revista Eletrônica Acervo Saúde, 2023; 27(1): e108.
GALE HB, et al. Is frequent CD4+ T-lymphocyte count monitoring necessary for persons with counts >=300 cells/μL and HIV-1 suppression? Revista Eletrônica Acervo Saúde, 2013; 56(9): e1340-3.
GBD 2017 HIV collaborators. Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. Revista Eletrônica Acervo Saúde, 2019; 6(12): e831-59.
GHIASVAND H, et al. Social and demographical determinants of quality of life in people who live with HIV/AIDS infection: evidence from a meta-analysis. Revista Eletrônica Acervo Saúde, 2020; 65(1): e57-72.
GHYS PD, et al. Epidemiological metrics and benchmarks for a transition in the HIV epidemic. Revista Eletrônica Acervo Saúde, 2018; 15(10): e1002678.
GONÇALES LFR, et al. Caracterização epidemiológica e clínica do HIV/Aids: associações com a mortalidade. Revista Eletrônica Acervo Saúde, 2021; 13(1): e5293.
GOVENDER RD, et al. Global Epidemiology of HIV/AIDS: A Resurgence in North America and Europe. Revista Eletrônica Acervo Saúde, 2021; 11(3): e296-301.
HARRIS PA, et al. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Revista Eletrônica Acervo Saúde, 2009; 42(2): e377-81.
JONES J, et al. Progress in the HIV epidemic: Identifying goals and measuring success. Revista Eletrônica Acervo Saúde, 2019; 16(1): e1002729.
KIM YJ, et al. Opportunistic diseases among HIV-infected patients: a multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013. Revista Eletrônica Acervo Saúde, 2016; 31(5): e953-60.
LAILULO Y, et al. Factors associated with antiretroviral treatment failure among people living with HIV on antiretroviral therapy in resource-poor settings: a systematic review and meta-analysis. Revista Eletrônica Acervo Saúde, 2020; 9(1): e292.
LAMPRECHT DJ, et al. Effect of HIV on mortality among hospitalised patients in South Africa. Revista Eletrônica Acervo Saúde, 2023; 24(1): e1477.
MA Y, et al. Long-Term Changes of HIV/AIDS Incidence Rate in China and the U.S. Population From 1994 to 2019: A Join-Point and Age-Period-Cohort Analysis. Revista Eletrônica Acervo Saúde, 2021; 15(9): e652868.
MARSHALL A, CAHILL S. Barriers and opportunities for the mental health of LGBT older adults and older people living with HIV: a systematic literature review. Revista Eletrônica Acervo Saúde, 2022; 26(9): e1845-54.
MATTOS COSTA J, et al. Adherence to antiretroviral therapy for HIV/AIDS in Latin America and the Caribbean: Systematic review and meta-analysis. Revista Eletrônica Acervo Saúde, 2018; 21(1): e25066.
MOTA TS, et al. Spatial risk of death in patients with AIDS in Campinas, São Paulo, Brazil. Revista Eletrônica Acervo Saúde, 2018; 21(1): e180017.
NAVARRO J. HIV and liver disease. Revista Eletrônica Acervo Saúde, 2022; 25(2): e87-96.
NOBRE NR, et al. Social networks of older adults living with HIV in Finland. Revista Eletrônica Acervo Saúde, 2016; 28(2): e186-90.
PINTO NETO LF, et al. Brazilian Protocol for Sexually Transmitted Infections 2020: HIV infection in adolescents and adults. Revista Eletrônica Acervo Saúde, 2021; 15(1): e2021.
POURCHER V, et al. Comorbidities in people living with HIV: An epidemiologic and economic analysis using a claims database in France. Revista Eletrônica Acervo Saúde, 2020; 15(12): e0243529.
RATHBUN RC, et al. The Medication Possession Ratio as a Predictor of Longitudinal HIV-1 Viral Suppression. Revista Eletrônica Acervo Saúde, 2023; 57(11): e1264-72.
REN N, et al. Patterns of HIV or AIDS Mortality Among Older People From 1990 to 2019 in China: Age-Period-Cohort Analysis. Revista Eletrônica Acervo Saúde, 2022; 8(11): e35785.
SANTANA JC, et al. Principais doenças oportunistas em indivíduos com HIV. Revista Eletrônica Acervo Saúde, 2019; 16(1): e2987.
SEYLER L, et al. Current challenges in the treatment of HIV. Revista Eletrônica Acervo Saúde, 2018; 128(10): e609-16.
SHIAU S, et al. The Current State of HIV and Aging: Findings Presented at the 10th International Workshop on HIV and Aging. Revista Eletrônica Acervo Saúde, 2020; 36(12): e973-81.
STASINOPOULOS MD, et al. Flexible regression and smoothing: using gamlss in R. Revista Eletrônica Acervo Saúde, 2017; 1(1): e1-8.
TCHAKOUTE C, et al. Adherence to contemporary antiretroviral treatment regimens and impact on immunological and virologic outcomes in a US healthcare system. Revista Eletrônica Acervo Saúde, 2022; 17(2): e0263742.
TEAM RC. R: A language and environment for statistical computing. Revista Eletrônica Acervo Saúde, 2020; 1(1): e1-8.
TSUI S, et al. HIV care and treatment models and their association with medication possession ratio among treatment-experienced adults in three African countries. Revista Eletrônica Acervo Saúde, 2021; 26(11): e1481-93.
WEICHSELDORFER M, et al. Past HIV-1 Medications and the Current Status of Combined Antiretroviral Therapy Options for HIV-1 Patients. Revista Eletrônica Acervo Saúde, 2021; 13(11): e1798.
YOSHIKURA H. Shift of HIV/AIDS Deaths to an Older Age and Gender Difference: Inferences Derived from the Vital Statistics of Japan. Revista Eletrônica Acervo Saúde, 2019; 72(6): e359-67.