Palabras clave
Cuello uterino
p16
Ck7
Biomarcadores
Cómo citar
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Resumen
Objetivo: Investigar potenciales marcadores moleculares como factores pronósticos en la metaplasia escamosa inmadura (ISM) en el cuello uterino y evaluar la importancia clínica del hallazgo de ISM típica y atípica en el epitelio cervical de la paciente. Métodos: Se seleccionaron un total de 79 casos en un estudio transversal retrospectivo (2011-2019). Las mujeres con ISM típica o atípica fueron evaluadas según criterios sociodemográficos, citológicos y de colposcopia. Las muestras de biopsia se evaluaron mediante análisis anatomopatológico e inmunohistoquímico, en el que se investigó la expresión de P16INK4a (p16) y Ck7. Resultados: El análisis citológico mostró una mayor frecuencia de células escamosas atípicas de significado indeterminado con lesiones de alto grado. En cuanto al análisis colposcópico, ambos grupos presentaron resultados similares. La negatividad de la expresión de p16 y Ck7 se asoció con un resultado favorable. Sin embargo, no se encontraron correlaciones entre la expresión de p16 y Ck7 y el ISM típico o atípico. Además, se obtuvo un valor de kappa de 0,087, lo que confirma la significativa variabilidad interobservador del estudio. Conclusión: La ausencia de p16 y Ck7 pueden ser utilizados como biomarcadores de pronóstico favorable, pero no mostraron correlaciones con las clasificaciones de ISM típico o atípico en el cuello uterino. Por lo tanto, se deben investigar más a fondo otras metodologías efectivas para el cribado de este perfil de paciente.
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