Resumen
Objetivo: Investigar os aspectos imaginológicos das alteraciones dentárias em sobrevivientes do câncer infantojuvenil, considerando os efectos tardíos da quimioterapia y radioterapia no desenvolvimento da coroa e raíces. Revisión bibliográfica: Los estudios analizados muestran que los pacientes sometidos a terapia antineoplásica durante la infancia pueden presentar agenesia dental, microdoncia, malformaciones radiculares e hipoplasia del esmalte. La gravedad de estos cambios está directamente relacionada con la edad de inicio del tratamiento, el tipo e intensidad de la terapia y la dosis de radiación aplicada. La exposición durante etapas críticas del desarrollo dental también puede afectar la formación de la lámina dental, lo que puede provocar retrasos en el inicio del desarrollo. Las radiografías panorámicas son apontadas como recurso fundamental para la detección precoz y para el acompañamiento longitudinal de las alteraciones, posibilitando un mejor plano terapéutico e intervención en el tiempo oportuno. Considerações finais: Sobrevivientes do câncer infantojuvenil presentan riesgo significativo de anomalías dentárias, exigindo acompañamiento clínico-radiográfico continuo. Apesar do avanço das terapias oncológicas, y padronização de protocolos de monitoramento odontológico todavía es una laguna que debe ser abordada en futuras pesquisas.
Referencias
AL-ANSARI S, et al. Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib. Genes, 2022; 13(7): 1198-1205.
BOWER J, et al. Acute and chronic effects of adjuvant therapy on inflammatory markers in breast cancer patients. JNCI Cancer Spectrum, 2022; 6.
CADILHO J. et al. Effects of radiation therapy on the morphology and composition of root dentin and cementum in primary teeth. Brazilian Oral Research, 2025; 39(1): 26-36.
CHIBUEZE EC, et al. Zika virus infection in pregnancy: a systematic review of disease course and complications. Reprod Health. 2017; 14(1): 28-33.
DE ALMEIDA HCR, et al. Bone age and dental late effects in childhood cancer survivors: Radiographic findings in a Brazilian sample. International Journal of Paediatric Dentistry, 2025; 35(1): 45–56.
DUARTE MEQ, et al. Fatores associados à cronologia de erupção de dentes decíduos – Revisão de Literatura: Erupção de dentes decíduos e fatores associados. Revista da Universidade Vale do Rio Verde, 2011; 9(1): 139-151.
GEBAUER J, et al. Long-term endocrine and metabolic consequences of cancer treatment: a systematic review. Endocrine Reviews, 2018; 40(3): 711–767.
GU X, et al. Chemotherapeutic and targeted drugs-induced immunogenic cell death in cancer models and antitumor therapy: an update review. Frontiers in Pharmacology, 2023; 14.
KANG C, et al. Clinical Risk Factors Influencing Dental Developmental Disturbances in Childhood Cancer Survivors. Cancer Res Treat, 2018; 50(3): 926-935.
KAMEL A, et al. The role of dental oncology in cancer care: a critical component of comprehensive treatment, education, and interdisciplinary collaboration – a narrative review. Journal of Cancer Education, 2025; 3(1): 1-10.
KASTE SC, et al. Impact of radiation and chemotherapy on risk of dental abnormalities: A report from the childhood cancer survivor study. Cancer, 2009; 115(24): 5817-5827.
LONGO B, et al. Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study. Clinical Oral Investigations, 2023; 27: 6637-6644.
LOPES J, et al. Chemotherapy and Radiotherapy Long-Term Adverse Effects on Oral Health of Childhood Cancer Survivors: A Systematic Review and Meta-Analysis. Cancers, 2023; 16(1): 110-116.
LUSTBERG M, et al. Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship. Nature Reviews Clinical Oncology, 2023; 1–16.
MUNHOZ L, et al. Head and neck radiotherapy-induced changes in dentomaxillofacial structures detected on panoramic radiographs: A systematic review. Imaging Science in Dentistry, 2021; 51(4): 223-235.
NOLLA CM. The development of the human dentition. ASDC J Dent Child, 1960; 27: 254-266.
PAHO. 1902. In: ORGANIZAÇÃO Pan-Americana da Saúde, Organização Mundial da Saúde. Disponível em: https://www.paho.org/en/campaigns/international-childhood-cancer-day. Acessado em: 25 de julho de 2025.
PATRICIO FB, et al. Fatores associados à cronologia de erupção dos dentes decíduos: revisão integrativa. Revista Eletrônica Acervo Saúde, 2021; 13(1): e6074.
PROC P, et al. Dental Anomalies as Late Adverse Effect among Young Children Treated for Cancer. Cancer Res Treat. 2016; 42(2): 658-667.
PUWANUN S, KRIANGKRAI R. Long-Term Oro-Dental Effects of Chemotherapy in a Pediatric Patient: A Case Study and a Proposed Oral Care Protocol. Journal of Clinical Medicine, 2025; 14(2): 603-608.
QUISPE RA, et al. A case-control study of dental abnormalities and dental maturity in childhood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol., 2019; 128(5): 498-505.
RITWIK P, CHRISENTERY-SINGLETON T. Oral and dental considerations in pediatric cancers. Cancer and Metastasis Reviews, 2020; 39(1): 43-53.
SCHMIDT ME et al. Late effects, long‐term problems and unmet needs of cancer survivors. International Journal of Cancer, 2022; 151: 1280–1290.
SILVEIRA FM, et al. Impacto do tratamento quimioterápico na qualidade de vida de pacientes oncológicos. Acta Paul Enferm. 2021; 34(2): 583-594.
SIMMER JP. Dental Enamel Formation and Its Impact on Clinical Dentistry. Journal of Dental Education. 2001; 65(1): 896-905.
SUH E, et al. Late mortality and chronic health conditions in long-term survivors of early- adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study. Lancet Oncol., 2020; 21(3): 421- 435.
TANEM KE, et al. Oral and dental late effects in long‑term survivors of childhood embryonal brain tumors. Supportive Care in Cancer, 2022; 30: 10233–10241.
YAN H, et al. Anticancer therapy-induced adverse drug reactions in children and preventive and control measures. Frontiers in Pharmacology, 2024; 15.
ZAHNREICH S, SCHMIDBERGER H. Childhood cancer: occurrence, treatment and risk of second primary malignancies. Cancers, 2021; 13.
ZULIJANI A, et al. Oligomicrodontia in a pediatric cancer survivor after chemotherapy: a case report. Healthcare, 2022; 10(1): 1521-1530.
