Perfil epidemiológico dos pacientes internados por Covid-19 em um hospital público de Minas Gerais
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Jul 6, 2022
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Objetivo: Descrever as características clínicas e epidemiológicas dos pacientes internados por Covid-19 em um hospital público de Minas Gerais. Métodos: Trata-se de um estudo observacional, transversal, com base em prontuários eletrônicos. A população foi constituída por pacientes com confirmação laboratorial para Covid-19 entre março de 2020 a março de 2021. Foram analisados dados demográficos, manifestações clínicas e comorbidades. Resultados: Foram incluídos 92 pacientes diagnosticados por Covid-19. A maioria dos pacientes era do sexo masculino (62,0%), com idade média de 58 anos. As comorbidades mais predominantes foram hipertensão (40,2%), diabetes (21,7%) e doenças cardíacas (9,8%). Os sintomas mais comuns foram dispneia (64,1%), febre (48,9%) e tosse seca (42,4%). Trinte e sete pacientes (40,2%) precisaram de cuidados em Unidade de Terapia Intensiva (UTI), e, destes, apenas um não recebeu suporte ventilatório invasivo. A taxa de mortalidade na instituição pesquisa foi de 33,7%. Conclusão: Conforme os dados apurados, observou-se que a maioria das pessoas infectadas por Covid-19 era do sexo masculino, com idade média de 58 anos e com ao menos uma doença de base. Os sintomas mais prevalentes foram dispneia, febre e tosse seca.
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SilvaR. P. da, ReisJ. A. dos, FernandesD. dos S., DiasB. J. de M. C., SantosF. B. O., BarbosaJ. A. G., CarregalF. A. dos S., SilvaB. G. da, SilvaG. A. T., & BarbosaL. P. da S. (2022). Perfil epidemiológico dos pacientes internados por Covid-19 em um hospital público de Minas Gerais. Revista Eletrônica Acervo Saúde, 15(7), e10540. https://doi.org/10.25248/reas.e10540.2022
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Referências
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34. WANG D, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11): 1061-1069.
35. WANG H, et al. The genetic sequence, origin, and diagnosis of SARS-CoV-2. Eur J Clin Microbiol Infect Dis., 2020; 39(9):1629-1635.
36. WORD HEALTH ORGANIZATION. WHO Coronavirus (COVID-19) Dashboard. 2022. Disponível em: https://covid19.who.int/. Acessado em: 3 de março de 2022.
37. XIE J, et al. Characteristics of patients with coronavirus disease (COVID‐19) confirmed using an IgM‐IgG antibody test. J Med Virol., 2020; 92: 2004–2010.
38. YANG X, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med., 2020; 8(5): 475–481.
39. YI C, et al. Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol., 2020; 17(6): 621-630.
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2. AKULA SM, MCCUBREY JA. Where are we with understanding of COVID-19?. Adv Biol Regul., 2020; 78: 100738.
3. ATZRODT CL, et al. A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2. FEBS J., 2020; 287(17): 3633-3650.
4. BHATRAJU PK, et al. Covid-19 in Critically Ill Patients in the Seattle Region — Case Series. N Engl J Med., 2020: NEJMoa2004500.
5. BRASIL. Protocolo de Manejo Clínico da Covid-19 na Atenção Especializada. 2020. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/manejo_clinico_covid-19_atencao_especializada.pdf. Acessado em: 22 de janeiro de 2022.
6. CENTERS FOR DISEASE CONTROL AND PREVENTION. COVID-19 Overview and Infection Prevention and Control Priorities in non-U.S. Healthcare Settings. 2021. Disponível em: https://www.cdc.gov/coronavirus/2019-ncov/hcp/non-us settings/overview/index.html. Acessado em: 21 de março de 2021.
7. CHAND S, et al. COVID-19-Associated Critical Illness—Report of the First 300 Patients Admitted to Intensive Care Units at a New York City Medical Center. Journal of Intensive Care Medicine, 2020; 35(10): 963-970.
8. CHEN N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 2020; 395(10223): 507–513.
9. CHEN Y, et al. Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res Rev., 2021; 65: 101205.
10. CHEN Z, et al. Clinical Characteristics of Patients with Severe and Critical COVID-19 in Wuhan: A Single-Center, Retrospective Study. Infect Dis Ther., 2021; 10(1): 421-438.
11. CHOI A, et al. Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants. Journal of Virology, 2021; 95(23): e01313-21.
12. CORRÊA TD, et al. Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study. Einstein (São Paulo), 2021; 19: 1-10.
13. FERRANDO C, et al. Características, evolución clínica y factores associados a la mortalidad en UCI de los pacientes críticos infectados por SARS-CoV-2 en Espana: ˜ estúdio prospectivo, de cohorte y multicêntrico. Rev Esp Anestesiol Reanim., 2020; 67(8): 425-437.
14. GANDHI RT, et al. Mild or Moderate Covid-19. N Engl J Med., 2020; 383: 1757-1766.
15. GRASSELLI G, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA, 2020; 323(16): 1574–1581.
16. HANG JJ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy, 2020; 75: 1730–1741.
17. HE F, et al. Coronavirus disease 2019: What we know?. J Med Virol., 2020; 92(7): 719-725.
18. HOSOKI K, et al. Molecular mechanisms and epidemiology of COVID-19 from an allergist’s perspective. J Allergy Clin Immunol., 2020; 146(2): 285-299.
19. ISER BPM, et al. Definição de caso suspeito da COVID-19: uma revisão narrativa dos sinais e sintomas mais frequentes entre os casos confirmados. Epidemiol. Serv. Saúde, 2020; 29(3): e2019354.
20. JAILLON S, et al. Sexual Dimorphism in Innate Immunity. Clinical Reviews in Allergy & Immunology, 2019; 56: 308–321.
21. JIN Y, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses, 2020; 12: 372.
22. KHALAF K, et al. SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment. Front Immunol., 2020; 11: 1-20.
23. KHAN M, et al. Epidemiological and clinical characteristics of coronavirus disease (COVID-19) cases at a screening clinic during the early outbreak period: a single-centre study. J Med Microbiol., 2020; 69(8): 1114–1123.
24. LI X, et al. Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China. International Journal of Infectious Diseases, 2020; 94: 128–132.
25. MACIEL EL, et al. Fatores associados ao óbito hospitalar por COVID-19 no Espírito Santo. Epidemiol. Serv. Saúde, 2020; 29: 4.
26. MATSUNAGA N, et al. Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan: Report of the COVID-19 Registry Japan. Clin Infect Dis., 2021; 73(11): e3677–e3689.
27. PAPANIKOLAOU V, et al. From delta to Omicron: S1-RBD/S2 mutation/deletion equilibrium in SARS-CoV-2 defined variants. Gene, 2022; 814: 146134.
28. PONTES L, et al. Perfil clínico e fatores associados ao óbito de pacientes COVID-19 nos primeiros meses da pandemia. Esc Anna Nery, 2022; 26: e20210203.
29. SHEERVALILOU R, et al. COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease. J Cell Physiol., 2020; 235: 8873–8924.
30. SHEPHERD R, et al. Sexual Dimorphism in Innate Immunity: The Role of Sex Hormones and Epigenetics. Front. Immunol., 2021; 11604000.
31. SULEYMAN G, et al. Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit. JAMA Network Open. 2020; 3(6): e2012270.
32. TEICH VD, et al. Características epidemiológicas e clínicas dos pacientes com COVID-19 no Brasil. Einstein (São Paulo), 2020; 18: 1-7.
33. TREVISOL FS, et al. Assessment of patients with Covid-19 hospitalized in southern Santa Catarina. Rev. Soc. Bras. Med. Trop., 2020; 53: e20200579.
34. WANG D, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11): 1061-1069.
35. WANG H, et al. The genetic sequence, origin, and diagnosis of SARS-CoV-2. Eur J Clin Microbiol Infect Dis., 2020; 39(9):1629-1635.
36. WORD HEALTH ORGANIZATION. WHO Coronavirus (COVID-19) Dashboard. 2022. Disponível em: https://covid19.who.int/. Acessado em: 3 de março de 2022.
37. XIE J, et al. Characteristics of patients with coronavirus disease (COVID‐19) confirmed using an IgM‐IgG antibody test. J Med Virol., 2020; 92: 2004–2010.
38. YANG X, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med., 2020; 8(5): 475–481.
39. YI C, et al. Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol., 2020; 17(6): 621-630.
40. YUAN M, et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science, 2020; 368: 630–633.