Eficacia de la neuroestimulación no invasiva para el tratamiento de los trastornos motores en la enfermedad de Parkinson
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Jul 6, 2022
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Objetivo: Verificar la efectividad de la neuroestimulación no invasiva para el tratamiento de la Enfermedad de Parkinson. Métodos: Esta fue una revisión cualitativa de la literatura en las bases de datos Lilacs, SciElo y Pubmed. Se incluyeron investigaciones sobre neuroestimulación para el alivio de los síntomas motores de la EP en los últimos cinco años. Se excluyeron los artículos cuyo tratamiento tuviera como único objetivo mejorar los síntomas cognitivos, así como los estudios que abordaran simultáneamente el tratamiento farmacológico y/o quirúrgico y el uso de la neuroestimulación para el tratamiento de otros síntomas u otras patologías. Resultados: Se encontraron 194 artículos y se seleccionaron 28 según los criterios de inclusión y 166 fueron excluidos. Se observaron efectos positivos en la mayoría de estos estudios, pero no hubo uniformidad en los protocolos utilizados. Consideraciones finales: Esta revisión de la literatura nos permitió comprender los efectos de la estimulación magnética transcraneal repetitiva, la estimulación transcraneal de corriente continua, la estimulación transcraneal de corriente alterna y la estimulación theta burst en los trastornos motores de la EP. Sin embargo, no se encontró uniformidad en los protocolos utilizados en los estudios. Por lo tanto, se necesitan más estudios clínicos con protocolos uniformes para evaluar mejor los posibles efectos sobre la neuroplasticidad motora.
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Cómo citar
RochaE., BarbozaE. de O., FigueiredoC. F. de, AssisS. K. J. S. de, OliveiraA. C., & SeferC. C. I. (2022). Eficacia de la neuroestimulación no invasiva para el tratamiento de los trastornos motores en la enfermedad de Parkinson. Revista Eletrônica Acervo Saúde, 15(7), e10620. https://doi.org/10.25248/reas.e10620.2022
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Citas
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2. BREEN DP, et al. Gut–brain axis and the spread of α‐synuclein pathology: vagal highway or dead end? Mov Disord., 2019; 34: 307–16.
3. BUENO MEB, et al. Effectiveness of acute transcranial direct current stimulation on non-motor and motor symptoms in Parkinson’s disease. Neuroscience Letters [Internet], 2019; 696: 46–51.
4. CHEN KS, CHEN R. Invasive and Noninvasive Brain Stimulation in Parkinson's Disease: Clinical Effects and Future Perspectives. Clin Pharmacol Ther., 2019; 106(4): 763-775.
5. CHUNG CL, et al. Transcranial Magnetic Stimulation Promotes Gait Training in Parkinson Disease. Ann Neurol., 2020; 88(5): 933-945.
6. COHEN OS, et al. Repetitive Deep TMS for Parkinson Disease: A 3-Month Double-Blind, Randomized Sham-Controlled Study. J Clin Neurophysiol., 2018; 35(2): 159-165.
7. CONCEIÇÃO NR, et al. Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition. Neurorehabilitation and Neural Repair, 2021; 35(8): 717–28.
8. DAGAN M, et al. Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease. Mov Disord., 2018; 33(4): 642-646.
9. DEL FELICE A, et al. Personalized transcranial alternating current stimulation (tACS) and physical therapy to treat motor and cognitive symptoms in Parkinson's disease: A randomized cross-over trial. Neuroimage Clin., 2019; 22: 101768.
10. DESIDÉRIO DL. Efeito de campos magnéticos estáticos e compensados na proliferação celular in vitro. 2017. 109f. Tese (Doutorado em Ciências Odontológicas Aplicadas: Biologia Oral) - Faculdade de Odontologia de Bauru da Universidade de São Paulo, Bauru, 2017.
11. GAGLIARDI R, TAKAYANAGUI OM. Tratado de Neurologia da Academia Brasileira de Neurologia. 2ª ed. Rio de Janeiro: Elsevier, 2019.
12. GIGUÈRE N, et al. On cell loss and selective vulnerability of neuronal populations in Parkinson's disease. Front Neurol., 2018; 19: 455.
13. GODEIRO C, et al. Use of non-invasive stimulation in movement disorders: a critical review. Arquivos de Neuro-Psiquiatria, 2021; 79(7): 630-646.
14. HANOGLU L, et al. Preliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson’s disease. Neurosci Lett., 2020; 724: 134837.
15. HORN MA, et al. A New Stimulation Mode for Deep Brain Stimulation in Parkinson's Disease: Theta Burst Stimulation. Mov Disord., 2020; 35(8): 1471-1475.
16. JANKOVIC J, TAN EK. Parkinson’s disease: etiopathogenesis and treatment Journal of Neurology, Neurosurgery & Psychiatry, 2020; 91: 795-808.
17. KHEDR EM, et al. The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Advancing Parkinson's Disease With Dysphagia: Double Blind Randomized Clinical Trial. Neurorehabil Neural Repair, 2019; 33(6): 442-452.
18. KHEDR EM, et al. The effect of repetitive transcranial magnetic stimulation on cognitive impairment in Parkinson’s disease with dementia: pilot study. Restor Neurol Neurosci., 2020; 38(1): 55-66.
19. LEE HK, et al. Does transcranial direct current stimulation improve functional locomotion in people with Parkinson’s disease? A systematic review and meta-analysis. Journal of NeuroEngineering and Rehabilitation, 2019; 16(1).
20. LEE S, KIM MK. The Effect of Transcranial Direct Current Stimulation Combined with Visual Cueing Training on Motor Function, Balance, and Gait Ability of Patients with Parkinson’s Disease. Medicina, 2021; 57(11): 1146.
21. LI S, et al. Motor recovery and antidepressant effects of repetitive transcranial magnetic stimulation on Parkinson disease: A PRISMA-compliant meta-analysis. Medicine (Baltimore), 2020; 99(18): e19642.
22. MALLY J, et al. Follow up study: The influence of rTMS with high and low frequency stimulation on motor and executive function in Parkinson's disease. Brain Res Bull, 2017; 135: 98-104.
23. MATSUDA RH, et al. Estimulação magnética transcraniana: uma breve revisão dos princípios e aplicações. Revista Brasileira De Física Médica, 2019; 13(1): 49-56.
24. MISHRA RK, THRASHER AT. Transcranial direct current stimulation of dorsolateral prefrontal cortex improves dual-task gait performance in patients with Parkinson's disease: A double blind, sham-controlled study. Gait Posture, 2021; 84: 11-16.
25. MULLIN S, SCHAPIRA AHV. Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease. Neurologic Clinics, 2015; 33(1): 1–17.
26. MURDOCK C, et al. Running Water Won’t Freeze: How people with advanced Parkinson’s disease experience occupation. Palliative & Supportive Care, Cambridge, 2015; 13(5): 1363-1372.
27. NASCIMENTO LR, et al. Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial. Trials, 2021; 22(1).
28. NOOHI S, AMIRSALARI S. History, studies and specific uses of repetitive transcranial magnetic stimulation (rTMS) in treating epilepsy. Iranian Journal of Child Neurology, 2016; 10(1): 1-8.
29. OLIVIERO A, et al. Transcranial static magnetic field stimulation of the human motor cortex. Journal of Physiology, 2011; 589(20): 4949–4958.
30. ORRU G, et al. The effect of single and repeated tDCS sessions on motor symptoms in Parkinson's disease: a systematic review. Arch Ital Biol., 2019; 157(2-3): 89-101.
31. POL F, et al. The effects of transcranial direct current stimulation on gait in patients with Parkinson's disease: a systematic review. Transl Neurodegener., 2021; 10(1): 22.
32. RIBEIRO AC, et al. Transcranial direct current stimulation associated with gait training in Parkinson's disease: A pilot randomized clinical trial. Dev Neurorehabil., 2017; 20(3): 121-128.
33. SADLER CM, et al. Transcranial direct current stimulation of supplementary motor area improves upper limb kinematics in Parkinson's disease. Clin Neurophysiol., 2021; 132(11): 2907-2915.
34. SANNA A, et al. Cerebellar continuous theta burst stimulation reduces levodopa-induced dyskinesias and decreases serum BDNF levels. Neurosci Lett., 2020; 716: 134653.
35. SIMPSON MW, MAK M. The effect of transcranial direct current stimulation on upper limb motor performance in Parkinson’s disease: a systematic review. Journal of Neurology, 2019; 267(12): 3479–88.
36. SONG IU, et al. Transcranial Direct Current Stimulation for the Treatment of Parkinson's Disease: Clinical and Regional Cerebral Blood Flow SPECT Outcomes. J Neuroimaging, 2020; 30(2): 161-164.
37. TEIVE HA, et al. Sintomas e sinais motores e não motores incomuns no estágio inicial da doença de Parkinson. Arq Neuropsiquiatr., 2016; 74(10): 781-4.
38. XIE YJ, et al. Effect of Repetitive Transcranial Magnetic Stimulation on Gait and Freezing of Gait in Parkinson Disease: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil., 2020; 101(1): 130-140.
39. YANG C, et al. Repetitive transcranial magnetic stimulation therapy for motor recovery in Parkinson's disease: A Meta-analysis. Brain Behav., 2018; 8(11): e01132.
40. WIRDEFELDT K, et al. Epidemiology and etiology of Parkinson’s disease: a review of the evidence. European Journal of Epidemiology, 2011; 26(S1): 1-58.
2. BREEN DP, et al. Gut–brain axis and the spread of α‐synuclein pathology: vagal highway or dead end? Mov Disord., 2019; 34: 307–16.
3. BUENO MEB, et al. Effectiveness of acute transcranial direct current stimulation on non-motor and motor symptoms in Parkinson’s disease. Neuroscience Letters [Internet], 2019; 696: 46–51.
4. CHEN KS, CHEN R. Invasive and Noninvasive Brain Stimulation in Parkinson's Disease: Clinical Effects and Future Perspectives. Clin Pharmacol Ther., 2019; 106(4): 763-775.
5. CHUNG CL, et al. Transcranial Magnetic Stimulation Promotes Gait Training in Parkinson Disease. Ann Neurol., 2020; 88(5): 933-945.
6. COHEN OS, et al. Repetitive Deep TMS for Parkinson Disease: A 3-Month Double-Blind, Randomized Sham-Controlled Study. J Clin Neurophysiol., 2018; 35(2): 159-165.
7. CONCEIÇÃO NR, et al. Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition. Neurorehabilitation and Neural Repair, 2021; 35(8): 717–28.
8. DAGAN M, et al. Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease. Mov Disord., 2018; 33(4): 642-646.
9. DEL FELICE A, et al. Personalized transcranial alternating current stimulation (tACS) and physical therapy to treat motor and cognitive symptoms in Parkinson's disease: A randomized cross-over trial. Neuroimage Clin., 2019; 22: 101768.
10. DESIDÉRIO DL. Efeito de campos magnéticos estáticos e compensados na proliferação celular in vitro. 2017. 109f. Tese (Doutorado em Ciências Odontológicas Aplicadas: Biologia Oral) - Faculdade de Odontologia de Bauru da Universidade de São Paulo, Bauru, 2017.
11. GAGLIARDI R, TAKAYANAGUI OM. Tratado de Neurologia da Academia Brasileira de Neurologia. 2ª ed. Rio de Janeiro: Elsevier, 2019.
12. GIGUÈRE N, et al. On cell loss and selective vulnerability of neuronal populations in Parkinson's disease. Front Neurol., 2018; 19: 455.
13. GODEIRO C, et al. Use of non-invasive stimulation in movement disorders: a critical review. Arquivos de Neuro-Psiquiatria, 2021; 79(7): 630-646.
14. HANOGLU L, et al. Preliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson’s disease. Neurosci Lett., 2020; 724: 134837.
15. HORN MA, et al. A New Stimulation Mode for Deep Brain Stimulation in Parkinson's Disease: Theta Burst Stimulation. Mov Disord., 2020; 35(8): 1471-1475.
16. JANKOVIC J, TAN EK. Parkinson’s disease: etiopathogenesis and treatment Journal of Neurology, Neurosurgery & Psychiatry, 2020; 91: 795-808.
17. KHEDR EM, et al. The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Advancing Parkinson's Disease With Dysphagia: Double Blind Randomized Clinical Trial. Neurorehabil Neural Repair, 2019; 33(6): 442-452.
18. KHEDR EM, et al. The effect of repetitive transcranial magnetic stimulation on cognitive impairment in Parkinson’s disease with dementia: pilot study. Restor Neurol Neurosci., 2020; 38(1): 55-66.
19. LEE HK, et al. Does transcranial direct current stimulation improve functional locomotion in people with Parkinson’s disease? A systematic review and meta-analysis. Journal of NeuroEngineering and Rehabilitation, 2019; 16(1).
20. LEE S, KIM MK. The Effect of Transcranial Direct Current Stimulation Combined with Visual Cueing Training on Motor Function, Balance, and Gait Ability of Patients with Parkinson’s Disease. Medicina, 2021; 57(11): 1146.
21. LI S, et al. Motor recovery and antidepressant effects of repetitive transcranial magnetic stimulation on Parkinson disease: A PRISMA-compliant meta-analysis. Medicine (Baltimore), 2020; 99(18): e19642.
22. MALLY J, et al. Follow up study: The influence of rTMS with high and low frequency stimulation on motor and executive function in Parkinson's disease. Brain Res Bull, 2017; 135: 98-104.
23. MATSUDA RH, et al. Estimulação magnética transcraniana: uma breve revisão dos princípios e aplicações. Revista Brasileira De Física Médica, 2019; 13(1): 49-56.
24. MISHRA RK, THRASHER AT. Transcranial direct current stimulation of dorsolateral prefrontal cortex improves dual-task gait performance in patients with Parkinson's disease: A double blind, sham-controlled study. Gait Posture, 2021; 84: 11-16.
25. MULLIN S, SCHAPIRA AHV. Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease. Neurologic Clinics, 2015; 33(1): 1–17.
26. MURDOCK C, et al. Running Water Won’t Freeze: How people with advanced Parkinson’s disease experience occupation. Palliative & Supportive Care, Cambridge, 2015; 13(5): 1363-1372.
27. NASCIMENTO LR, et al. Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson’s disease: study protocol for a randomized clinical trial. Trials, 2021; 22(1).
28. NOOHI S, AMIRSALARI S. History, studies and specific uses of repetitive transcranial magnetic stimulation (rTMS) in treating epilepsy. Iranian Journal of Child Neurology, 2016; 10(1): 1-8.
29. OLIVIERO A, et al. Transcranial static magnetic field stimulation of the human motor cortex. Journal of Physiology, 2011; 589(20): 4949–4958.
30. ORRU G, et al. The effect of single and repeated tDCS sessions on motor symptoms in Parkinson's disease: a systematic review. Arch Ital Biol., 2019; 157(2-3): 89-101.
31. POL F, et al. The effects of transcranial direct current stimulation on gait in patients with Parkinson's disease: a systematic review. Transl Neurodegener., 2021; 10(1): 22.
32. RIBEIRO AC, et al. Transcranial direct current stimulation associated with gait training in Parkinson's disease: A pilot randomized clinical trial. Dev Neurorehabil., 2017; 20(3): 121-128.
33. SADLER CM, et al. Transcranial direct current stimulation of supplementary motor area improves upper limb kinematics in Parkinson's disease. Clin Neurophysiol., 2021; 132(11): 2907-2915.
34. SANNA A, et al. Cerebellar continuous theta burst stimulation reduces levodopa-induced dyskinesias and decreases serum BDNF levels. Neurosci Lett., 2020; 716: 134653.
35. SIMPSON MW, MAK M. The effect of transcranial direct current stimulation on upper limb motor performance in Parkinson’s disease: a systematic review. Journal of Neurology, 2019; 267(12): 3479–88.
36. SONG IU, et al. Transcranial Direct Current Stimulation for the Treatment of Parkinson's Disease: Clinical and Regional Cerebral Blood Flow SPECT Outcomes. J Neuroimaging, 2020; 30(2): 161-164.
37. TEIVE HA, et al. Sintomas e sinais motores e não motores incomuns no estágio inicial da doença de Parkinson. Arq Neuropsiquiatr., 2016; 74(10): 781-4.
38. XIE YJ, et al. Effect of Repetitive Transcranial Magnetic Stimulation on Gait and Freezing of Gait in Parkinson Disease: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil., 2020; 101(1): 130-140.
39. YANG C, et al. Repetitive transcranial magnetic stimulation therapy for motor recovery in Parkinson's disease: A Meta-analysis. Brain Behav., 2018; 8(11): e01132.
40. WIRDEFELDT K, et al. Epidemiology and etiology of Parkinson’s disease: a review of the evidence. European Journal of Epidemiology, 2011; 26(S1): 1-58.