A exposição ao piriproxifeno causa microcefalia? Uma revisão sistemática de efeitos tóxicos em dois modelos animais
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Jan 28, 2023
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Resumo
Objetivo: Este estudo objetivou avaliar os estudos sobre a toxicidade do piriproxifeno em modelos animais de peixe-zebra e murino e sua relação com a microcefalia. Métodos: Para busca foram utilizadas as palavras-chave pyriproxyfen and toxicity nas plataformas Pubmed, Scorpus, ScieLo e ScienceDirect. Foram selecionados os artigos que utilizaram as palavras-chaves no título ou resumo. Os critérios de inclusão foram: artigos em inglês ou português que descrevessem um estudo experimental in vivo ou in vitro com zebrafish (Danio rerio) e murinos. As informações extraídas foram o ano de publicação, país, modelo animal e desfechos de toxicidade. Resultados: Foram selecionados 13 artigos. Exposição a concentrações de aplicação acima da recomendação são tóxicas. Não foi observado evidências de microcefalia. Observamos um aumento no número de publicações após a epidemia, o país com maior número de publicação foi o Brasil e o peixe-zebra foi modelo mais utilizado. Considerações finais: Baseado nos estudos o piriproxifeno não está relacionado como causa da microcefalia, entretanto causa efeitos tóxicos. Diante da grande utilização deste larvicida em programas de controles de arboviroses recomendamos sua utilização com cautela.
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Como Citar
PadilhaR. M. O., SilvaJ. F. da, MagnaboscoA. R. dos S., GomesS. da S., CadenaM. R. S., & CadenaP. G. (2023). A exposição ao piriproxifeno causa microcefalia? Uma revisão sistemática de efeitos tóxicos em dois modelos animais. Revista Eletrônica Acervo Saúde, 23(1), e11068. https://doi.org/10.25248/reas.e11068.2023
Seção
Revisão Bibliográfica
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Referências
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2. ARAÚJO TVB, et al. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. The Lancet infectious diseases, 2018; 18(3): 328-336.
3. AZEVEDO RD, et al. Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase. Chemosphere, 2020; 263: 128029.
4. BRASIL. Boletim Epidemiológico: Síndrome congênita associada à infecção pelo vírus Zika, situação epidemiológica, ações desenvolvidas e desafios de 2015 a 2019, 2019. Disponível em:http://www. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes. Acessado em: 26 de junho de 2021.
5. BRASIL. Orientações técnica para utilização do larvicida pyriproxyfen (0,5 G) no controle de Aedes aegypti, 2014. Disponível em: https://www.saude.gov.br/images/pdf/.../Instrucoes-para-uso-de-pyriproxifen-maio-2014.pdf. Acessado em: 20 de março de 2021.
6. BREETA RE, et al. Non-toxic and non teratogenic extract of Thuja orientalis L. inhibited angiogenesis in zebrafish and suppressed the growth of human lung cancer cell line. Biomedicine & Pharmacotherapy, 2018; 106: 699–706.
7. CAMPOS KB, et al. Assessment of the susceptibility status of Aedes aegypti (Diptera: Culicidae) populations to pyriproxyfen and malathion in nation-wide monitoring of insecticide resistance performed in Brazil from 2017 to 2018. Parasites Vectors, 2020; 13: 531.
8. CHŁOPECKA M, et al. The effect of pyriproxyfen on the motoric activity of rat intestine-In vitro study. Environmental Pollution, 2018; 241: 1146-1152.
9. DEVILLERS J. Fate and ecotoxicological effects of pyriproxyfen in aquatic ecosystems. Environmental Science and Pollution Research, 2020; 27(14): 16052-16068.
10. DZIECIOLOWSKA S, et al. The larvicide pyriproxyfen blamed during the Zika virus outbreak does not cause microcephaly in zebrafish embryos. Scientific Reports Nature, 2017; 7: 40067.
11. CRISTOFOLI F, et al. Variantes de novo em LMNB1 causam microcefalia sindrômica pronunciada e ruptura da integridade do envelope nuclear. The American Journal of Human Genetics, 2020; 107(4): 753-762.
12. GONÇALVES ÍFS, et al. Toxicity testing of pesticides in zebrafish—a systematic review on chemicals and associated toxicological endpoints. Environmental Science and Pollution Research, 2020; 27(10): 10185-10204.
13. GUSSO D, et al. Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish. Frontiers in Behavioral Neuroscience, 2020; 14: 103.
14. BECERRA-SOLANO LE, et al. Microcephaly, an etiopathogenic vision. Pedi Neo, 2021; 62(4): 354-360.
15. HORIE Y, et al. Assessment of the lethal and sublethal effects of 20 environmental chemicals in zebrafish embryos and larvae by using OECD TG 212. Journal of Applied Toxicology, 2017; 37(10): 245-1253.
16. KOHNKEN R, et al. A. Overview of the use of murine models in leukemia and lymphoma research. Frontiers in oncology, 2017; 7(22).
17. LI M, et al. Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae. Chemosphere, 2019; 219: 155-164.
18. MAHARAJAN K, et al. Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): a multi-biomarker study. Aquatic. Toxicology, 2018; 196: 132–145.
19. MAHARAJAN K, et al. "Pyriproxyfen induced impairment of reproductive endocrine homeostasis and gonadal histopathology in zebrafish (Danio rerio) by altered expression of hypothalamus-pituitary-gonadal (HPG) axis genes." Science of The Total Environment, 2020; 139496.
20. MAOZ D, et al. Community effectiveness of pyriproxyfen as a dengue vector control method: a systematic review. PLoS Neglected Tropical Diseases, 2017; 11(7): 1–20.
21. MOURA JAA e SOUZA-SANTOS LP. Environmental risk assessment (ERA) of pyriproxyfen in non-target aquatic organisms. Aquatic Toxicology, 2020; 222: 1-9.
22. WORLD HEALTH ORGANIZATION (WHO). Pyriproxyfen in Drinking-water: Use for Vector Control in Drinking-water Sources and Containers. 2008. Disponível em: https://cdn.who.int/media/docs/default-source/wash-documents/wash-chemicals/pyriproxyfen-background.pdf?sfvrsn=ef4b9372_4. Acessado em: 30 de Junho de 2021.
23. PARENS R, et al. Possible link between pyriproxyfen and microcephaly. PLOS Currents, 2017; 1.
24. PADILLA S, et al. Zebrafish developmental screening of the ToxCast Phase I chemical library. Reproductive Toxicology, 2012; 33: 174-187.
25. REGALDIE AG, et al. Zebrafish Models of Autosomal Recessive Ataxias. Cells, 2021; 10(4): 836.
26. RICHARDSON JR, et al. Neurotoxicity of pesticides. Acta neuropathologica, 2019; 138(3): 343-362.
27. ROPER C e TANGUAY RL. Zebrafish as a model for developmental biology and toxicology. 2ª Edition. Oregon: Oregon State University, Handbook of developmental neurotoxicology; 2018.
28. HUSTEDT JC, et al. Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. Plos Neglected Tropical Diseases, 2020; 14(6): e0008205.
29. SARTORI AS, et al. Avaliação da toxicidade pré-natal: estudo de teratogenicidade do inseticida piriproxifeno em ratos Wistar. Arq Brasileiro de Medicina Veterinária e Zootecnia, 2020; 72(3): 719-728.
30. SHAHID A e SAHER M. Repeated exposure of pyriproxyfen to pregnant female mice causes developmental abnormalities in prenatal pups. Environmental Science and Pollution Research, 2020; 27(21): 26998-27009.
31. SCHMIDT HR, et al. Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system. Toxicology and Applied Pharmacology, 2015; 284(2): 197-203.
32. SPIRHANZLOVA P, et al. The pyriproxyfen metabolite 4’OH-pyriproxyfen disrupts thyroid hormone signaling and enhances Musashi-1 levels in neuro progenitor. bioRxiv, 2018; 352088.
33. TRUONG L, et al. Assessment of the developmental and neurotoxicity of the mosquito control larvicide, pyriproxyfen, using embryonic zebrafish. Environmental Pollution, 2016; 1-5.
34. VAN DER LINDEN H, et al. Epilepsy and EEG Abnormalities in Congenital Zika Syndrome. Journal of Clinical Neurophysiology, 2022; 39(4): 248-252.
35. VANI JM, et al. Pyriproxyfen does not cause microcephaly or malformations in a preclinical mammalian model. Environmental Science and Pollution Research, 2020; 28(4): 4585-4593.
36. WEEKS ENI, et al. Novel effective mosquito larvicide DL-methionine: Lack of toxicity to non-target aquatic organisms. Ecotoxicology and Environmental Safety, 2021; 213: 102013.
2. ARAÚJO TVB, et al. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. The Lancet infectious diseases, 2018; 18(3): 328-336.
3. AZEVEDO RD, et al. Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase. Chemosphere, 2020; 263: 128029.
4. BRASIL. Boletim Epidemiológico: Síndrome congênita associada à infecção pelo vírus Zika, situação epidemiológica, ações desenvolvidas e desafios de 2015 a 2019, 2019. Disponível em:http://www. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes. Acessado em: 26 de junho de 2021.
5. BRASIL. Orientações técnica para utilização do larvicida pyriproxyfen (0,5 G) no controle de Aedes aegypti, 2014. Disponível em: https://www.saude.gov.br/images/pdf/.../Instrucoes-para-uso-de-pyriproxifen-maio-2014.pdf. Acessado em: 20 de março de 2021.
6. BREETA RE, et al. Non-toxic and non teratogenic extract of Thuja orientalis L. inhibited angiogenesis in zebrafish and suppressed the growth of human lung cancer cell line. Biomedicine & Pharmacotherapy, 2018; 106: 699–706.
7. CAMPOS KB, et al. Assessment of the susceptibility status of Aedes aegypti (Diptera: Culicidae) populations to pyriproxyfen and malathion in nation-wide monitoring of insecticide resistance performed in Brazil from 2017 to 2018. Parasites Vectors, 2020; 13: 531.
8. CHŁOPECKA M, et al. The effect of pyriproxyfen on the motoric activity of rat intestine-In vitro study. Environmental Pollution, 2018; 241: 1146-1152.
9. DEVILLERS J. Fate and ecotoxicological effects of pyriproxyfen in aquatic ecosystems. Environmental Science and Pollution Research, 2020; 27(14): 16052-16068.
10. DZIECIOLOWSKA S, et al. The larvicide pyriproxyfen blamed during the Zika virus outbreak does not cause microcephaly in zebrafish embryos. Scientific Reports Nature, 2017; 7: 40067.
11. CRISTOFOLI F, et al. Variantes de novo em LMNB1 causam microcefalia sindrômica pronunciada e ruptura da integridade do envelope nuclear. The American Journal of Human Genetics, 2020; 107(4): 753-762.
12. GONÇALVES ÍFS, et al. Toxicity testing of pesticides in zebrafish—a systematic review on chemicals and associated toxicological endpoints. Environmental Science and Pollution Research, 2020; 27(10): 10185-10204.
13. GUSSO D, et al. Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish. Frontiers in Behavioral Neuroscience, 2020; 14: 103.
14. BECERRA-SOLANO LE, et al. Microcephaly, an etiopathogenic vision. Pedi Neo, 2021; 62(4): 354-360.
15. HORIE Y, et al. Assessment of the lethal and sublethal effects of 20 environmental chemicals in zebrafish embryos and larvae by using OECD TG 212. Journal of Applied Toxicology, 2017; 37(10): 245-1253.
16. KOHNKEN R, et al. A. Overview of the use of murine models in leukemia and lymphoma research. Frontiers in oncology, 2017; 7(22).
17. LI M, et al. Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae. Chemosphere, 2019; 219: 155-164.
18. MAHARAJAN K, et al. Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): a multi-biomarker study. Aquatic. Toxicology, 2018; 196: 132–145.
19. MAHARAJAN K, et al. "Pyriproxyfen induced impairment of reproductive endocrine homeostasis and gonadal histopathology in zebrafish (Danio rerio) by altered expression of hypothalamus-pituitary-gonadal (HPG) axis genes." Science of The Total Environment, 2020; 139496.
20. MAOZ D, et al. Community effectiveness of pyriproxyfen as a dengue vector control method: a systematic review. PLoS Neglected Tropical Diseases, 2017; 11(7): 1–20.
21. MOURA JAA e SOUZA-SANTOS LP. Environmental risk assessment (ERA) of pyriproxyfen in non-target aquatic organisms. Aquatic Toxicology, 2020; 222: 1-9.
22. WORLD HEALTH ORGANIZATION (WHO). Pyriproxyfen in Drinking-water: Use for Vector Control in Drinking-water Sources and Containers. 2008. Disponível em: https://cdn.who.int/media/docs/default-source/wash-documents/wash-chemicals/pyriproxyfen-background.pdf?sfvrsn=ef4b9372_4. Acessado em: 30 de Junho de 2021.
23. PARENS R, et al. Possible link between pyriproxyfen and microcephaly. PLOS Currents, 2017; 1.
24. PADILLA S, et al. Zebrafish developmental screening of the ToxCast Phase I chemical library. Reproductive Toxicology, 2012; 33: 174-187.
25. REGALDIE AG, et al. Zebrafish Models of Autosomal Recessive Ataxias. Cells, 2021; 10(4): 836.
26. RICHARDSON JR, et al. Neurotoxicity of pesticides. Acta neuropathologica, 2019; 138(3): 343-362.
27. ROPER C e TANGUAY RL. Zebrafish as a model for developmental biology and toxicology. 2ª Edition. Oregon: Oregon State University, Handbook of developmental neurotoxicology; 2018.
28. HUSTEDT JC, et al. Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. Plos Neglected Tropical Diseases, 2020; 14(6): e0008205.
29. SARTORI AS, et al. Avaliação da toxicidade pré-natal: estudo de teratogenicidade do inseticida piriproxifeno em ratos Wistar. Arq Brasileiro de Medicina Veterinária e Zootecnia, 2020; 72(3): 719-728.
30. SHAHID A e SAHER M. Repeated exposure of pyriproxyfen to pregnant female mice causes developmental abnormalities in prenatal pups. Environmental Science and Pollution Research, 2020; 27(21): 26998-27009.
31. SCHMIDT HR, et al. Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system. Toxicology and Applied Pharmacology, 2015; 284(2): 197-203.
32. SPIRHANZLOVA P, et al. The pyriproxyfen metabolite 4’OH-pyriproxyfen disrupts thyroid hormone signaling and enhances Musashi-1 levels in neuro progenitor. bioRxiv, 2018; 352088.
33. TRUONG L, et al. Assessment of the developmental and neurotoxicity of the mosquito control larvicide, pyriproxyfen, using embryonic zebrafish. Environmental Pollution, 2016; 1-5.
34. VAN DER LINDEN H, et al. Epilepsy and EEG Abnormalities in Congenital Zika Syndrome. Journal of Clinical Neurophysiology, 2022; 39(4): 248-252.
35. VANI JM, et al. Pyriproxyfen does not cause microcephaly or malformations in a preclinical mammalian model. Environmental Science and Pollution Research, 2020; 28(4): 4585-4593.
36. WEEKS ENI, et al. Novel effective mosquito larvicide DL-methionine: Lack of toxicity to non-target aquatic organisms. Ecotoxicology and Environmental Safety, 2021; 213: 102013.