Avaliação do perfil oxidativo na rinite alérgica relacionada à classificação clínica: estudo transversal
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Resumo
Objetivo: Analisar o perfil oxidativo de pacientes portadores de Rinite Alérgica Persistente, relacionando a sua classificação clínica (leve ou moderada-severa). Métodos: Trata-se de um estudo do tipo transversal, com coleta de dados entre 09/2021 e 02/2022. Após a estratificação clínica de pacientes previamente diagnosticados foi realizada uma coleta de sangue para determinação dos parâmetros hematológicos e bem como para avaliação espectrofotométrica dos marcadores relacionados ao perfil oxidativo. Resultados: Os dois grupos avaliados apresentaram predomínio do sexo feminino, média etária de aproximadamente 30 anos e relataram fazer uso de automedicação. Não foi observado diferença significativa na capacidade antioxidante total entre os grupos avaliados, entretanto os níveis de atividade da enzima antioxidante Catalase se apresentaram significativamente reduzidos no grupo com rinite moderada-severa (91,2 + 90,5 vs. 148,5 + 111,3 μm/L; p=0,048), interessantemente observamos correlação positiva entre os níveis de catalase com proteínas carboniladas (r=0,437 e p=0,0253) e de catalase com índice de massa corporal (r=0,4109 e p=0,037) apenas neste grupo. Conclusão: Nossos dados demonstram que os pacientes com quadros mais graves de rinite alérgica apresentam maiores alterações dos marcadores oxidativos, que se correlacionam positivamente com fatores de risco de agravo do referido quadro.
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