Abordagens terapêuticas na Síndrome do Ovário Policístico
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Publicado
Feb 7, 2023
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Resumo
Objetivo: Identificar as terapêuticas utilizadas no tratamento da Síndrome do Ovário Policístico (SOP) discutidas na comunidade científica, como uma forma de ajudar na escolha terapêutica. Métodos: Revisão bibliográfica integrativa da literatura, através da busca ativa nas bases de dados Biblioteca Virtual em Saúde, U.S National Library of Medicine and the National Institutes Health e EBSCOHost, mediante uso de dois Descritores em Ciência da Saúde na língua inglesa, acrescidos do operador booleano, AND << “Polycystic Ovary Syndrome” AND Therapeutics >>, publicados nos últimos cinco anos e com texto completo. Resultados: A amostra final, composta por 33 artigos, evidenciou predomínio de publicações do Egito e China, na EBSCOHost e estudos clínicos prospectivos. Quanto ao tratamento, foram identificados o Letrozol para infertilidade, a intervenção dietética e modulação da microbiota intestinal para o hiperandrogenismo, e Metformina para as alterações metabólicas presente na SOP. Considerações finais: As terapêuticas utilizadas no tratamento da síndrome do ovário policístico devem ser de acordo com a queixa individual da paciente e sua eficácia, sendo as mais estudadas o Letrozol, a intervenção dietética, a modulação da microbiota intestinal e a Metformina.
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Como Citar
PecoraroL. M., & SousaM. N. A. de. (2023). Abordagens terapêuticas na Síndrome do Ovário Policístico. Revista Eletrônica Acervo Saúde, 23(2), e11596. https://doi.org/10.25248/reas.e11596.2023
Seção
Revisão Bibliográfica
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Referências
1. ABBARA A, et al. Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders. The Journal of clinical investigation, 2020; 130(12): e6739-6753.
2. ABU HASHIM H, et al. Unilateral or bilateral laparoscopic ovarian drilling in polycystic ovary syndrome: a meta-analysis of randomized trials. Archives of Gynecology and Obstetrics, 2018; 297(4): e859-870.
3. ACMAZ G, et al. The effects of oral isotretinoin in women with acne and polycystic ovary syndrome. BioMed research international, 2019; 2019(1): e1-5.
4. AHMED A, et al. Clomiphene citrate and metformin" stair step" protocol vs. traditional protocol in patients with polycystic ovary syndrome" PCOS". Egyptian Journal of Hospital Medicine, 2018; 72(5): e4463-4468.
5. AKINOSO-IMRAN AQ e ADETUNJI H. Systematic review and meta-analysis of letrozole and clomiphene citrate in polycystic ovary syndrome. Middle East Fertility Society Journal, 2018; 23(3): e163-170.
6. ALKOUDSI KT, et al. A. Assessing the effectiveness of a pharmaceutical care service on the quality of life of women with polycystic ovarian syndrome living in war and non-war countries. J Eval Clin Pract, 2020; 26(5): e1467-1477.
7. ALOBAIDI MT, et al. Impact of letrozole versus clomiphene citrate on endometrial receptivity in Iraqi women with polycystic ovarian syndrome. Journal of Clinical Pharmacy and Therapeutics, 2019; 44(4): e618-622.
8. ALTINOK ML, et al. Effect of 12-month treatment with metformin and/or oral contraceptives on health-related quality of life in polycystic ovary syndrome. Gynecological Endocrinology, 2018; (34)10: e859-863.
9. ARENTZ S, et al. Combined lifestyle and herbal medicine in overweight women with polycystic ovary syndrome (PCOS): a randomized controlled trial. Phytotherapy research, 2017; 31(9): e1330-1340.
10. CENA H, et al. Obesity, polycystic ovary syndrome, and infertility: a new avenue for GLP-1 receptor agonists. The Journal of Clinical Endocrinology & Metabolism, 2020; 105(8): e2695-2709.
11. CHE X, et al. Dietary Interventions: A Promising Treatment for Polycystic Ovary Syndrome. Annals of Nutrition and Metabolism, 2021; 77(6): e313-323.
12. D’AMATO G, et al. Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. Reproductive Biology and Endocrinology, 2018; 16(1): e1-8.
13. EL FAHAM D, et al. Can Amlodipine Improve the Pre-ovulatory Follicle Blood Flow in Women with Polycystic Ovarian Syndrome? Journal of Reproduction & Infertility, 2019; 20(2): e89.
14. FRUZZETTI F, et al. Treatment with d-chiro-inositol and alpha lipoic acid in the management of polycystic ovary syndrome. Gynecological Endocrinology, 2019; 35(6): e506-510.
15. FURAT RENCBER S, et al. Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. Journal of ovarian research, 2018; 11(1): e1-16.
16. GADALLA MA, et al. Medical and surgical treatment of reproductive outcomes in polycystic ovary syndrome: an overview of systematic reviews. International journal of fertility & sterility, 2020; 13(4): e257.
17. GU Y, et al. Gut and Vaginal Microbiomes in PCOS: Implications for Women’s Health. Frontiers in Endocrinology, 2022; 13(1): e1-9.
18. HU K, et al. Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction. Reproductive Biology and Endocrinology, 2022; 20(1): e1-20.
19. JIN P e XIE Y. Treatment strategies for women with polycystic ovary syndrome. Gynecological Endocrinology, 2018; 34(4): e272-277.
20. JONAS CF. Uso terapêutico de mio-inositol como tratamento em pacientes com síndrome do ovário policístico. UFRGS, 2019; 1(1): e1-41.
21. KAMAL D, et al. Beneficial effects of green tea catechins on female reproductive disorders: A review. Molecules, 2021; 26(9): e2675.
22. KAMBOJ MK e BONNY AE. Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies. Translational pediatrics, 2017; 6(4): e248.
23. LAGANÀ AS, et al. Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials. Archives of Gynecology and Obstetrics, 2018; 298(4): e675-684.
24. MEIER RK. Polycystic ovary syndrome. Nursing Clinics, 2018; 53(3): e407-420.
25. MELO AEF, et al. Benefícios do uso de metformina em pacientes com síndrome dos ovários policísticos. Revista Ciência & Desenvolvimento, 2019; 12(3): e502-519.
26. MOKHTARI F, et al. Effects of melatonin administration on chemical pregnancy rates of polycystic ovary syndrome patients undergoing intrauterine insemination: a randomized clinical trial. International journal of fertility & sterility, 2019; 13(3): e225.
27. NASRI K, et al. The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. BMC Endocrine Disorders, 2018; 18(1): 1-8.
28. PATHMANATHAN S, et al. A Case of Successful Treatment with Unilateral Oophorectomy in a Patient with Resistant Polycystic Ovary Syndrome. Case Reports in Endocrinology, 2020; 2020(1): e1-6.
29. QI X, et al. Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome. Nature medicine, 2019; 25(8): e1225-1233.
30. RAHMANI E, et al. The effects of fish oil on gene expression in patients with polycystic ovary syndrome. European journal of clinical investigation, 2018; 48(3): e12893.
31. REGIDOR P, et al. Chronic inflammation in PCOS: the potential benefits of specialized pro-resolving lipid mediators (SPMs) in the improvement of the resolutive response. International Journal of Molecular Sciences, 2020; 22(1): e384.
32. ROSA-E-SILVA AC. Conceito, epidemiologia e fisiopatologia aplicada à prática clínica. In: Síndrome dos ovários policísticos. Federação Brasileira das Associações de Ginecologia e Obstetrícia, 2018; 2018(1): e1-15.
33. SACHDEVA G, et al. Prediction of responsiveness to clomiphene citrate in infertile women with PCOS. Journal of Reproduction & Infertility, 2019; 20(3): e143.
34. SHAMASBI SG, et al. The effect of resistant dextrin as a prebiotic on metabolic parameters and androgen level in women with polycystic ovarian syndrome: a randomized, triple-blind, controlled, clinical trial. European journal of nutrition, 2019; 58(2): e629-640.
35. SHARMA S, et al. Efficacy of metformin in the treatment of acne in women with polycystic ovarian syndrome: a newer approach to acne therapy. The Journal of clinical and aesthetic dermatology, 2019; 12(5): e34.
36. SKORUPSKAITE K, et al. Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome. Human Reproduction, 2020; 35(6): e1421.
37. SOUSA LMM, et al. A metodologia de revisão integrativa da literatura em enfermagem. Revista Investigação em Enfermagem, 2017; 17(2): e17-26.
38. SOUSA MNA. Revisão integrativa da literatura: esclarecendo o método. Medicina e Pesquisa, 2016; 1(1): e345-358.
39. YAMAN FK e ARSLAN S. Effects of progesterone treatment in polycystic ovary syndrome on pulmonary functions. Türk Hijyen ve Deneysel Biyoloji Dergisi, 2019; 76(2): e203-210.
40. ZAHRAN KM, et al. Clomiphene citrate plus cabergoline versus clomiphene citrate for induction of ovulation in infertile euprolactinemic patients with polycystic ovary syndrome: A randomized clinical trial. Middle East Fertility Society Journal, 2018; 23(3): e173-177.
2. ABU HASHIM H, et al. Unilateral or bilateral laparoscopic ovarian drilling in polycystic ovary syndrome: a meta-analysis of randomized trials. Archives of Gynecology and Obstetrics, 2018; 297(4): e859-870.
3. ACMAZ G, et al. The effects of oral isotretinoin in women with acne and polycystic ovary syndrome. BioMed research international, 2019; 2019(1): e1-5.
4. AHMED A, et al. Clomiphene citrate and metformin" stair step" protocol vs. traditional protocol in patients with polycystic ovary syndrome" PCOS". Egyptian Journal of Hospital Medicine, 2018; 72(5): e4463-4468.
5. AKINOSO-IMRAN AQ e ADETUNJI H. Systematic review and meta-analysis of letrozole and clomiphene citrate in polycystic ovary syndrome. Middle East Fertility Society Journal, 2018; 23(3): e163-170.
6. ALKOUDSI KT, et al. A. Assessing the effectiveness of a pharmaceutical care service on the quality of life of women with polycystic ovarian syndrome living in war and non-war countries. J Eval Clin Pract, 2020; 26(5): e1467-1477.
7. ALOBAIDI MT, et al. Impact of letrozole versus clomiphene citrate on endometrial receptivity in Iraqi women with polycystic ovarian syndrome. Journal of Clinical Pharmacy and Therapeutics, 2019; 44(4): e618-622.
8. ALTINOK ML, et al. Effect of 12-month treatment with metformin and/or oral contraceptives on health-related quality of life in polycystic ovary syndrome. Gynecological Endocrinology, 2018; (34)10: e859-863.
9. ARENTZ S, et al. Combined lifestyle and herbal medicine in overweight women with polycystic ovary syndrome (PCOS): a randomized controlled trial. Phytotherapy research, 2017; 31(9): e1330-1340.
10. CENA H, et al. Obesity, polycystic ovary syndrome, and infertility: a new avenue for GLP-1 receptor agonists. The Journal of Clinical Endocrinology & Metabolism, 2020; 105(8): e2695-2709.
11. CHE X, et al. Dietary Interventions: A Promising Treatment for Polycystic Ovary Syndrome. Annals of Nutrition and Metabolism, 2021; 77(6): e313-323.
12. D’AMATO G, et al. Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. Reproductive Biology and Endocrinology, 2018; 16(1): e1-8.
13. EL FAHAM D, et al. Can Amlodipine Improve the Pre-ovulatory Follicle Blood Flow in Women with Polycystic Ovarian Syndrome? Journal of Reproduction & Infertility, 2019; 20(2): e89.
14. FRUZZETTI F, et al. Treatment with d-chiro-inositol and alpha lipoic acid in the management of polycystic ovary syndrome. Gynecological Endocrinology, 2019; 35(6): e506-510.
15. FURAT RENCBER S, et al. Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. Journal of ovarian research, 2018; 11(1): e1-16.
16. GADALLA MA, et al. Medical and surgical treatment of reproductive outcomes in polycystic ovary syndrome: an overview of systematic reviews. International journal of fertility & sterility, 2020; 13(4): e257.
17. GU Y, et al. Gut and Vaginal Microbiomes in PCOS: Implications for Women’s Health. Frontiers in Endocrinology, 2022; 13(1): e1-9.
18. HU K, et al. Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction. Reproductive Biology and Endocrinology, 2022; 20(1): e1-20.
19. JIN P e XIE Y. Treatment strategies for women with polycystic ovary syndrome. Gynecological Endocrinology, 2018; 34(4): e272-277.
20. JONAS CF. Uso terapêutico de mio-inositol como tratamento em pacientes com síndrome do ovário policístico. UFRGS, 2019; 1(1): e1-41.
21. KAMAL D, et al. Beneficial effects of green tea catechins on female reproductive disorders: A review. Molecules, 2021; 26(9): e2675.
22. KAMBOJ MK e BONNY AE. Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies. Translational pediatrics, 2017; 6(4): e248.
23. LAGANÀ AS, et al. Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials. Archives of Gynecology and Obstetrics, 2018; 298(4): e675-684.
24. MEIER RK. Polycystic ovary syndrome. Nursing Clinics, 2018; 53(3): e407-420.
25. MELO AEF, et al. Benefícios do uso de metformina em pacientes com síndrome dos ovários policísticos. Revista Ciência & Desenvolvimento, 2019; 12(3): e502-519.
26. MOKHTARI F, et al. Effects of melatonin administration on chemical pregnancy rates of polycystic ovary syndrome patients undergoing intrauterine insemination: a randomized clinical trial. International journal of fertility & sterility, 2019; 13(3): e225.
27. NASRI K, et al. The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. BMC Endocrine Disorders, 2018; 18(1): 1-8.
28. PATHMANATHAN S, et al. A Case of Successful Treatment with Unilateral Oophorectomy in a Patient with Resistant Polycystic Ovary Syndrome. Case Reports in Endocrinology, 2020; 2020(1): e1-6.
29. QI X, et al. Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome. Nature medicine, 2019; 25(8): e1225-1233.
30. RAHMANI E, et al. The effects of fish oil on gene expression in patients with polycystic ovary syndrome. European journal of clinical investigation, 2018; 48(3): e12893.
31. REGIDOR P, et al. Chronic inflammation in PCOS: the potential benefits of specialized pro-resolving lipid mediators (SPMs) in the improvement of the resolutive response. International Journal of Molecular Sciences, 2020; 22(1): e384.
32. ROSA-E-SILVA AC. Conceito, epidemiologia e fisiopatologia aplicada à prática clínica. In: Síndrome dos ovários policísticos. Federação Brasileira das Associações de Ginecologia e Obstetrícia, 2018; 2018(1): e1-15.
33. SACHDEVA G, et al. Prediction of responsiveness to clomiphene citrate in infertile women with PCOS. Journal of Reproduction & Infertility, 2019; 20(3): e143.
34. SHAMASBI SG, et al. The effect of resistant dextrin as a prebiotic on metabolic parameters and androgen level in women with polycystic ovarian syndrome: a randomized, triple-blind, controlled, clinical trial. European journal of nutrition, 2019; 58(2): e629-640.
35. SHARMA S, et al. Efficacy of metformin in the treatment of acne in women with polycystic ovarian syndrome: a newer approach to acne therapy. The Journal of clinical and aesthetic dermatology, 2019; 12(5): e34.
36. SKORUPSKAITE K, et al. Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome. Human Reproduction, 2020; 35(6): e1421.
37. SOUSA LMM, et al. A metodologia de revisão integrativa da literatura em enfermagem. Revista Investigação em Enfermagem, 2017; 17(2): e17-26.
38. SOUSA MNA. Revisão integrativa da literatura: esclarecendo o método. Medicina e Pesquisa, 2016; 1(1): e345-358.
39. YAMAN FK e ARSLAN S. Effects of progesterone treatment in polycystic ovary syndrome on pulmonary functions. Türk Hijyen ve Deneysel Biyoloji Dergisi, 2019; 76(2): e203-210.
40. ZAHRAN KM, et al. Clomiphene citrate plus cabergoline versus clomiphene citrate for induction of ovulation in infertile euprolactinemic patients with polycystic ovary syndrome: A randomized clinical trial. Middle East Fertility Society Journal, 2018; 23(3): e173-177.