Defeitos peri-implantares tratados com plasma rico em plaquetas e plasma rico em fibrinas
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Resumo
Objetivo: Investigar o plasma rico em plaquetas (PRP) e plasma rico em fibrina (PRF) em defeitos ósseos peri-implantares. Métodos: Um defeito ósseo medindo 05 mm em formato retangular com extremidades arredondadas foi preparado na tíbia esquerda de 36 ratos e um implante foi instalado. Os animais foram divididos em 3 grupos: controle (CO), plasma rico em plaquetas (PRP) e plasma rico em fibrina (PRF). Previamente aos procedimentos cirúrgicos, foram coletados 3ml de sangue de cada animal via punção cardíaca, para centrifugação e obtenção de PRP e PRF. Após 20 e 40 dias, a neoformação óssea e a estabilidade do implante foram avaliadas por histomorfometria e análise biomecânica. Resultados: Na análise biomecânica houve diferença estatística significantes intergrupos aos 20 para os grupos PRP com CO (<0,001) e diferença intragrupos entre 20 e 40 dias para o CO PRP e PRF (<0,001), adotando p<0,05). Os dados da área óssea neoformada (AON) demonstraram maior formação óssea nos grupos PRP e PRF em relação ao grupo controle. Em 40 dias, houve neoformação óssea em todos os grupos, sendo mais evidente no grupo PRP. Conclusão: A aplicação do PRP em defeitos peri-implantares em tíbias de ratos demonstrou ser mais efetiva na resposta de estabilidade do implante e neoformação óssea, sendo superior ao PRF e ao grupo controle.
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