Efeitos terapêuticos da Anredera cordifolia
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Jul 21, 2023
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Objetivo: Revisar e compilar as produções científicas acerca dos efeitos terapêuticos da planta Anredera cordifolia. Métodos: Revisão integrativa da literatura, apresentando a questão: Quais são os efeitos terapêuticos da planta Anredera cordifolia em estudos laboratoriais com seres humanos, animais e modelos celulares? A coleta de dados foi realizada nas bases de dados PubMed, Scopus e Web of Science, no mês de janeiro de 2023. Os achados foram agrupados em categorias temáticas relacionadas aos efeitos terapêuticos da planta Anredera cordifolia, com posterior revisão/síntese e discussão do conhecimento. Resultados: A amostra foi composta por 33 artigos que corresponderam aos critérios de seleção. As evidências científicas sobre os efeitos terapêuticos da planta estão centradas na ação cicatricial, atividade antibacteriana, analgésica, anti-hipertensiva, anti-hiperuricêmica, anti-hiperlipidêmica e citotóxica. E no tratamento da insuficiência renal, efeito antiobesidade, anti-hiperglicêmico, anticataratogênese, efeitos no aprendizado e memória de ratos, bem como na melhora da fertilidade de ratos. Considerações finais: O estudo permitiu concluir os efeitos terapêuticos da planta Anredera cordifolia, descritos com ação cicatricial, atividade antibacteriana, analgésica, anti-hipertensiva, anti-hiperuricêmica, anti-hiperlipidêmica e citotóxica. E no tratamento da insuficiência renal, efeito antiobesidade, efeito antihiperglicêmico, efeito anticataratogênese, efeitos no aprendizado, memória e fertilidade. Demonstrou, ainda a ausência de estudos desenvolvidos por pesquisadores brasileiros.
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Como Citar
HeislerE. V., TrombiniF. dos S., PerottoniJ., ChelottiM. E., CruzI. B. M. da, BarbisanF., & SchimithM. D. (2023). Efeitos terapêuticos da Anredera cordifolia. Revista Eletrônica Acervo Saúde, 23(7), e12736. https://doi.org/10.25248/reas.e12736.2023
Seção
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Referências
1. ALBA TM, et al. Seasonal effect on phenolic content and antioxidant activity of young, mature and senescent leaves from Anredera cordifolia (Ten.) Steenis (Basellaceae). Brazilian Journal of Biology, 2024; 84: e254174.
2. BAHTIAR A, et al. The Antioxidant Effects of the Ethanolic Extract of Binahong Leaves Unilateral Ureteral Obstruction Rat Model. Pharmacog J, 2021; 13(1): 185-8.
3. BRASIL. Ministério da Saúde, Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Departamento de Assistência Farmacêutica. Plantas Medicinais e Fitoterapicos no SUS. 2022. Disponível em: https://www.gov.br/saude/pt-br/composicao/sctie/daf/pnpmf/plantas-medicinais-e-fitoterapicos-no-sus. Acessado em: 13 de janeiro de 2023.
4. DWITIYANTI D, et al. Binahong (Anredera cordifolia (Tenore) Steen.) Leaf Extract Modulates Fatty Acids and Amino Acids to Lower Blood Glucose in High-Fat Diet-Induced Diabetes Mellitus Rats. Advances in Pharmacological and Pharmaceutical Sciences, 2021; 2021: 1-8.
5. DWITIYANTI D, et al. The Effect of 96% Ethanol Extract of Binahong Leaf on Hyperglycemia White Male Rats Using Total Cholesterol and Triglyceride Parameters. IOP Conf. Series: Earth and Environmental Science, 2021; 755: 012005.
6. FEBRIANSAH R e LAKSHITA HA. Co-Chemotherapeutic Effect of n-Hexane Fraction of Binahong (Anredera cordifolia [Tenore] Steen.) on WiDr Colon Cancer Cell Line. Open Access Maced J Med Sci, 2021; 9(T4):77-82.
7. FERIYANI F, et al. The Analysis of Binahong Leaves Potential (Anredera cordifolia) as an Alternative Treatment of Anticataractogenesis. Open Access Maced J Med Sci, 2020; 8(B):820-24.
8. FERIYANI F, et al. Effects of Binahong (Anredera cordifolia (Tenore) Steenis) Extracts on the Levels of Malondialdehyde (MDA) in Cataract Goat Lenses. The Scientific World Journal, 2021; 2021:1-6.
9. GARMANA NA, et al. Preliminary Study of Blood Pressure Lowering Effect of Anredera cordifolia (Ten.) Steenis) on Wistar Rats. IJPPR, 2016; 8(2): 300-04.
10. GARMANA NA, et al. Antihipertension study of Anredera cordifolia (Tem.). V. Steenis extract and its fractions in rats through dexamethasone induction and nitric oxide release. Asian J Pharm Clin Res, 2018; 11(1): 278-82.
11. GREGORIO JPRS. Propagação e controle de Anredera cordifolia (Tem.) Stennis. Dissertação (Mestrado em Agricultura e Ambiente). Universidade Federal de São Carlos, Araras, 2020.
12. HANAFIAH OA, et al. Wound Healing Activity of Binahong (Anredera cordifolia (Ten.) Steenis) Leaves Extract towards NIH-3T3 Fibroblast Cells. Journal of International Dental and Medical Research, 2019; 12(3):854-58.
13. HANAFIAH OA, et al. The Effect of Topical Application of 3% Binahong (Anredera cordifolia (Ten) Steenis) Leaves Extract Gel on the Radiographic Bone Density in Post-Extraction Socket. J Int Dent Med Res, 2021; 14(2):736-41.
14. HANAFIAH OA, et al. Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus). F1000 Research, 2022; 10:923.
15. HAPSARI AF, et al. Burn Healing with Binahong (Anredera cordifolia (Tenore) Steenis) Leaves extract as a topical and systemic treatments. Advances in Health Science Research, 2017; 10:05-09.
16. HEISLER EV, et al. Tendências da produção científica brasileira sobre a planta Anredera cordifolia. In: Silva CDD, Mota DA. A pesquisa em CIÊNCIAS BIOLÓGICAS: Desafios atuais e perspectivas futuras. Ponta Grossa (PR): Atena, 2021; 135-47p.
17. KHOSWANTO C e SOEHARDJO I. The effect of Binahong Gel (Anredera cordifolia (Ten.) Steenis) in accelerating the escalation expression of HIF-1α and FGF-2. Journal of International Dental and Medical Research, 2018; 11(1): 303-07.
18. KHOSWANTO C. Optimum Concentration Anredera cordifolia (Ten.) Steenis Gel in Increasing the Expression BMP-2 and the number of Osteoblasts Post Tooth Extraction in Wistar Rats. Journal of International Dental and Medical Research, 2019; 12(3): 959-63.
19. KHOSWANTO C. Microvascular Activity from the Wound Healing Process in Wistar Rats Due to Administration of Anredera Cordifolia (Ten.) Steenis. J Int Dent Med Res, 2021; 14(4): 1351-56.
20. LESTARI D, et al. Anredera cordifolia Leaves Extract as Antihyperlipidemia and Endothelial Fat Content Reducer in Male Wistar Rat. IJPCR, 2015; 7(6): 435-39.
21. MANTHOVANI AZ, et al. The expression. of Ins1 Gene in Streptozotocin-Induced Male Sprague Dawley Rats and Treated by Binahong (Anredera cordifolia) Leaf Extract and Sambiloto (Andrographis paniculata) Leaf Extract. Mal J Med Health Sci, 2022; 18(SUPP16): 45-49.
22. MENDES KDS, et al. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enferm, 2008; 17(4): 758-64.
23. MINAYO MCS. Análise qualitativa: teoria, passos e fidedignidade. Ciênc Saúde Colet, 2012; 17(3): 621-6.
24. PAGE MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2021; 372: 71.
25. PAKADANG SR, et al. MIC and MKC Analysis of Herbal Phcogj.com Medicine in Indonesia Against Mycobacterium tuberculosis. Pharmacogn J, 2021; 13(5): 1058-64.
26. PITALOKA DAE e SUKANDAR EY. Synergistic Study on n-Hexane Extract of Anredera cordifolia (Ten.)v Steenis (binahong) Leaves Combined with Antituberculosis Drugs against Drug-Sensitive and Drug-Resistant of Mycobacterium tuberculosis. Journal of Applied Pharmaceutical Science, 2018; 8(05): 134-38.
27. RAMADHAN A. The Effectiveness of Binahong (Anredera cordifolia (Ten.) Steenis) Extract in Promoting Fertility in Male Wistar Rats after Exposure to Cigarette Smoke. Open Access Maced J Med Sci, 2021; 9(A): 123-8.
28. SUKANDAR EY, et al. Efficacy of etanol extract of Anredera cordifolia (Tem.) Steenis leaves on improving kidney failure in rats. Int. J. Pharmacol, 2011; 7(8): 850-55.
29. SUKANDAR EY, et al. Vasodilatation effect of ethanolic extract of Anredera cordifolia, Sonchus arvensis l, and ursolic acid on isolated rabbit aortic and frog heart. Int J Pharm Pharm Sci, 2016; 8(2): 145-49.
30. SUKANDAR EY, et al. Antiobesity effect of etanol extract of Anredera cordifolia (Ten.) Steenis leaves on obese male wistar rats induced by high-carbohydrate diet. Int J Pharm Pharm Sci, 2016; 8(4): 171-73.
31. SUKANDAR EY, et al. Antihypertensive activity of ethanol extract combination of Anredera cordifolia (Ten.) v. Steenis and Sonchus arvensis L. leaves on angiotensin II- induced male wistar rat. J Res Pharm, 2019; 23(6): 1090-97.
32. SULISKA N, et al. Antihypertensive Activity of Combination of Anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. Leaves on Epinephrine Induced Male Wistar Rat. J. Adv. Pharm. Technol. Res, 2021; 12:384-8.
33. SUMARTININGSIH S. The Effect of Binahong to Hematoma. International Scholarly and Scientific Research & Innovation, 2011; 5(6): 244-46.
34. SUMIYOSHI E, et al. Anredera cordifolia extract enhances learning and memory in senescence- accelerated mouse-prone 8 (SAMP8) mice. Food Funct, 2021; 12: 3992–4004.
35. SUTRISNO E, et al. Wound healing in vivo and in vitro study of binahong leaves (Anredera cordifolia (Ten.) Steenis) and pegagan (Centella asiatica (L.) Urban) ethanolic extract. PhOl, 2018; 1: 111-16.
36. TSHIKALANGE TE, et al. Antimicrobial activity, toxicity and the isolation of a bioactive compound from plants used to treat sexually transmitted diseases. J Ethnopharmacol, 2005; 96(3): 515–19.
37. Universidade Federal do Rio de Janeiro (UFRJ). Rio de Janeiro: Anredera cordifolia (Ten.) Steenis, 2021.
Disponível em: http://www.unirio.br/ccbs/ibio/herbariohuni/anredera-cordifolia-ten-steenis. Acessado em: 15 de janeiro de 2023.
38. VIRGINIA DM, et al. Cytotoxic activity of Anredera cordifolia leaf extract on hela cells. Biotropia, 2019; 26(1): 33-40.
39. WAHJUNI S, et al. Effects of Binahong (Anredera Cordifolia) Leaf Ethanol Extracts on Blood Glucose Levels and Pancreas Histopathology in Hyperglycemic Rats. Journal of Global Pharma Technology, 2019; 11(4): 437-42.
40. WIDYARINI KD, et al. Xanthine oxidase inhibitory and antihyperuricemic activities of Anredera cordifolia (ten) steenis, sonchus arvensis l, and its combination. Int J Pharm Pharm Sci, 2015; 7(3): 86- 90.
41. YUNIARTI WM e LUKISWANTO BS. Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten.) Steenis) for burn wound healing process on albino rats. Vet World, 2017; 10(7): 808-13.
42. YUZIANI, et al. Evaluation of Analgesic Activities of Ethanolic Extract of Anredera Cordifolia (Ten) Steenis Leaf. Int. J. PharmTech Res, 2014; 6(5): 1608-10.
2. BAHTIAR A, et al. The Antioxidant Effects of the Ethanolic Extract of Binahong Leaves Unilateral Ureteral Obstruction Rat Model. Pharmacog J, 2021; 13(1): 185-8.
3. BRASIL. Ministério da Saúde, Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Departamento de Assistência Farmacêutica. Plantas Medicinais e Fitoterapicos no SUS. 2022. Disponível em: https://www.gov.br/saude/pt-br/composicao/sctie/daf/pnpmf/plantas-medicinais-e-fitoterapicos-no-sus. Acessado em: 13 de janeiro de 2023.
4. DWITIYANTI D, et al. Binahong (Anredera cordifolia (Tenore) Steen.) Leaf Extract Modulates Fatty Acids and Amino Acids to Lower Blood Glucose in High-Fat Diet-Induced Diabetes Mellitus Rats. Advances in Pharmacological and Pharmaceutical Sciences, 2021; 2021: 1-8.
5. DWITIYANTI D, et al. The Effect of 96% Ethanol Extract of Binahong Leaf on Hyperglycemia White Male Rats Using Total Cholesterol and Triglyceride Parameters. IOP Conf. Series: Earth and Environmental Science, 2021; 755: 012005.
6. FEBRIANSAH R e LAKSHITA HA. Co-Chemotherapeutic Effect of n-Hexane Fraction of Binahong (Anredera cordifolia [Tenore] Steen.) on WiDr Colon Cancer Cell Line. Open Access Maced J Med Sci, 2021; 9(T4):77-82.
7. FERIYANI F, et al. The Analysis of Binahong Leaves Potential (Anredera cordifolia) as an Alternative Treatment of Anticataractogenesis. Open Access Maced J Med Sci, 2020; 8(B):820-24.
8. FERIYANI F, et al. Effects of Binahong (Anredera cordifolia (Tenore) Steenis) Extracts on the Levels of Malondialdehyde (MDA) in Cataract Goat Lenses. The Scientific World Journal, 2021; 2021:1-6.
9. GARMANA NA, et al. Preliminary Study of Blood Pressure Lowering Effect of Anredera cordifolia (Ten.) Steenis) on Wistar Rats. IJPPR, 2016; 8(2): 300-04.
10. GARMANA NA, et al. Antihipertension study of Anredera cordifolia (Tem.). V. Steenis extract and its fractions in rats through dexamethasone induction and nitric oxide release. Asian J Pharm Clin Res, 2018; 11(1): 278-82.
11. GREGORIO JPRS. Propagação e controle de Anredera cordifolia (Tem.) Stennis. Dissertação (Mestrado em Agricultura e Ambiente). Universidade Federal de São Carlos, Araras, 2020.
12. HANAFIAH OA, et al. Wound Healing Activity of Binahong (Anredera cordifolia (Ten.) Steenis) Leaves Extract towards NIH-3T3 Fibroblast Cells. Journal of International Dental and Medical Research, 2019; 12(3):854-58.
13. HANAFIAH OA, et al. The Effect of Topical Application of 3% Binahong (Anredera cordifolia (Ten) Steenis) Leaves Extract Gel on the Radiographic Bone Density in Post-Extraction Socket. J Int Dent Med Res, 2021; 14(2):736-41.
14. HANAFIAH OA, et al. Effects of 3% binahong (Anredera cordifolia) leaf extract gel on alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus). F1000 Research, 2022; 10:923.
15. HAPSARI AF, et al. Burn Healing with Binahong (Anredera cordifolia (Tenore) Steenis) Leaves extract as a topical and systemic treatments. Advances in Health Science Research, 2017; 10:05-09.
16. HEISLER EV, et al. Tendências da produção científica brasileira sobre a planta Anredera cordifolia. In: Silva CDD, Mota DA. A pesquisa em CIÊNCIAS BIOLÓGICAS: Desafios atuais e perspectivas futuras. Ponta Grossa (PR): Atena, 2021; 135-47p.
17. KHOSWANTO C e SOEHARDJO I. The effect of Binahong Gel (Anredera cordifolia (Ten.) Steenis) in accelerating the escalation expression of HIF-1α and FGF-2. Journal of International Dental and Medical Research, 2018; 11(1): 303-07.
18. KHOSWANTO C. Optimum Concentration Anredera cordifolia (Ten.) Steenis Gel in Increasing the Expression BMP-2 and the number of Osteoblasts Post Tooth Extraction in Wistar Rats. Journal of International Dental and Medical Research, 2019; 12(3): 959-63.
19. KHOSWANTO C. Microvascular Activity from the Wound Healing Process in Wistar Rats Due to Administration of Anredera Cordifolia (Ten.) Steenis. J Int Dent Med Res, 2021; 14(4): 1351-56.
20. LESTARI D, et al. Anredera cordifolia Leaves Extract as Antihyperlipidemia and Endothelial Fat Content Reducer in Male Wistar Rat. IJPCR, 2015; 7(6): 435-39.
21. MANTHOVANI AZ, et al. The expression. of Ins1 Gene in Streptozotocin-Induced Male Sprague Dawley Rats and Treated by Binahong (Anredera cordifolia) Leaf Extract and Sambiloto (Andrographis paniculata) Leaf Extract. Mal J Med Health Sci, 2022; 18(SUPP16): 45-49.
22. MENDES KDS, et al. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enferm, 2008; 17(4): 758-64.
23. MINAYO MCS. Análise qualitativa: teoria, passos e fidedignidade. Ciênc Saúde Colet, 2012; 17(3): 621-6.
24. PAGE MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2021; 372: 71.
25. PAKADANG SR, et al. MIC and MKC Analysis of Herbal Phcogj.com Medicine in Indonesia Against Mycobacterium tuberculosis. Pharmacogn J, 2021; 13(5): 1058-64.
26. PITALOKA DAE e SUKANDAR EY. Synergistic Study on n-Hexane Extract of Anredera cordifolia (Ten.)v Steenis (binahong) Leaves Combined with Antituberculosis Drugs against Drug-Sensitive and Drug-Resistant of Mycobacterium tuberculosis. Journal of Applied Pharmaceutical Science, 2018; 8(05): 134-38.
27. RAMADHAN A. The Effectiveness of Binahong (Anredera cordifolia (Ten.) Steenis) Extract in Promoting Fertility in Male Wistar Rats after Exposure to Cigarette Smoke. Open Access Maced J Med Sci, 2021; 9(A): 123-8.
28. SUKANDAR EY, et al. Efficacy of etanol extract of Anredera cordifolia (Tem.) Steenis leaves on improving kidney failure in rats. Int. J. Pharmacol, 2011; 7(8): 850-55.
29. SUKANDAR EY, et al. Vasodilatation effect of ethanolic extract of Anredera cordifolia, Sonchus arvensis l, and ursolic acid on isolated rabbit aortic and frog heart. Int J Pharm Pharm Sci, 2016; 8(2): 145-49.
30. SUKANDAR EY, et al. Antiobesity effect of etanol extract of Anredera cordifolia (Ten.) Steenis leaves on obese male wistar rats induced by high-carbohydrate diet. Int J Pharm Pharm Sci, 2016; 8(4): 171-73.
31. SUKANDAR EY, et al. Antihypertensive activity of ethanol extract combination of Anredera cordifolia (Ten.) v. Steenis and Sonchus arvensis L. leaves on angiotensin II- induced male wistar rat. J Res Pharm, 2019; 23(6): 1090-97.
32. SULISKA N, et al. Antihypertensive Activity of Combination of Anredera cordifolia (Ten.) V. Steenis and Sonchus arvensis L. Leaves on Epinephrine Induced Male Wistar Rat. J. Adv. Pharm. Technol. Res, 2021; 12:384-8.
33. SUMARTININGSIH S. The Effect of Binahong to Hematoma. International Scholarly and Scientific Research & Innovation, 2011; 5(6): 244-46.
34. SUMIYOSHI E, et al. Anredera cordifolia extract enhances learning and memory in senescence- accelerated mouse-prone 8 (SAMP8) mice. Food Funct, 2021; 12: 3992–4004.
35. SUTRISNO E, et al. Wound healing in vivo and in vitro study of binahong leaves (Anredera cordifolia (Ten.) Steenis) and pegagan (Centella asiatica (L.) Urban) ethanolic extract. PhOl, 2018; 1: 111-16.
36. TSHIKALANGE TE, et al. Antimicrobial activity, toxicity and the isolation of a bioactive compound from plants used to treat sexually transmitted diseases. J Ethnopharmacol, 2005; 96(3): 515–19.
37. Universidade Federal do Rio de Janeiro (UFRJ). Rio de Janeiro: Anredera cordifolia (Ten.) Steenis, 2021.
Disponível em: http://www.unirio.br/ccbs/ibio/herbariohuni/anredera-cordifolia-ten-steenis. Acessado em: 15 de janeiro de 2023.
38. VIRGINIA DM, et al. Cytotoxic activity of Anredera cordifolia leaf extract on hela cells. Biotropia, 2019; 26(1): 33-40.
39. WAHJUNI S, et al. Effects of Binahong (Anredera Cordifolia) Leaf Ethanol Extracts on Blood Glucose Levels and Pancreas Histopathology in Hyperglycemic Rats. Journal of Global Pharma Technology, 2019; 11(4): 437-42.
40. WIDYARINI KD, et al. Xanthine oxidase inhibitory and antihyperuricemic activities of Anredera cordifolia (ten) steenis, sonchus arvensis l, and its combination. Int J Pharm Pharm Sci, 2015; 7(3): 86- 90.
41. YUNIARTI WM e LUKISWANTO BS. Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten.) Steenis) for burn wound healing process on albino rats. Vet World, 2017; 10(7): 808-13.
42. YUZIANI, et al. Evaluation of Analgesic Activities of Ethanolic Extract of Anredera Cordifolia (Ten) Steenis Leaf. Int. J. PharmTech Res, 2014; 6(5): 1608-10.