Funcionalidade e qualidade de vida de pacientes com osteoartrite do joelho após terapia rica em plaquetas
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Aug 9, 2023
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Resumo
Objetivo: Avaliar a capacidade funcional e a qualidade de vida de pacientes com osteoartrite de joelho submetidos à injeção de plasma rico em plaquetas. Métodos: Estudo observacional transversal realizado com 31 sujeitos atendidos no ambulatório de ortopedia de um hospital universitário de um município do noroeste do Paraná, de 2016 a 2017. Para a coleta de dados, foi utilizado um questionário sociodemográfico, o Short Form36 e o Questionário Algofuncional de Lequesne. Para análise dos dados, foram utilizadas estatísticas descritivas, com medidas de dispersão, intervalo interquartílico e teste Wilcoxon não paramétrico. Foi estabelecido um nível de confiança de 95%, e as associações com p < 0,05 foram consideradas estatisticamente significativas. Todas as análises foram realizadas utilizando o ambiente estatístico R. Resultados: A maioria dos pacientes eram do sexo feminino, com idade média de 59,8 anos (DP ± 12,2). Na pré-intervenção com plasma rico em plaquetas, todos os sujeitos foram classificados na categoria extremamente severa. Houve uma melhoria significativa em todos os oito domínios do Form-36 curto, bem como redução da dor e recuperação funcional nos 31 pacientes. Conclusão: A terapia rica em plaquetas através de injeção em pacientes com osteoartrite do joelho melhorou a qualidade de vida e reduziu a dor com o aumento da capacidade operacional.
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Como Citar
RiedoC. de O., SouzaM. P. de, SalvaraniW., GavioliA., EvangelistaF. F., OliveiraN. L. B. de, PellosoS. M., BitencourtM. R., EggerP. A., & CarvalhoM. D. de B. (2023). Funcionalidade e qualidade de vida de pacientes com osteoartrite do joelho após terapia rica em plaquetas. Revista Eletrônica Acervo Saúde, 23(8), e12983. https://doi.org/10.25248/reas.e12983.2023
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Referências
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15. KON E, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: From early degeneration to osteoarthritis. Arthroscopy - Journal of Arthroscopic and Related Surgery, 2011; 27(11): 1490–1501.
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17. LAGUARDIA J, et al. Brazilian normative data for the Short Form 36 questionnaire, version 2. Revista Brasileira de Epidemiologia, 2013; 16(4): 889–897.
18. LI W, et al. The application of platelet-rich plasma in the treatment of knee osteoarthritis: A literature review. Journal of Orthopaedic Science, 2022; 27(2): 420–428.
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21. MARX FC, et al. Tradução e validação cultural do questionário algofuncional de Lequesne para osteoartrite de joelhos e quadris para a língua portuguesa. Revista Brasileira de Reumatologia, 2006; 46(4): 253–260.
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24. MUCHEDZI TA e ROBERTS SB. A systematic review of the effects of platelet rich plasma on outcomes for patients with knee osteoarthritis and following total knee arthroplasty. Surgeon, 2018; 16(4): 250–258.
25. PATEL S, et al. Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis. The American Journal of Sports Medicine, 2013; 41(2): 356–364.
26. PAVANI AA e FERNANDES TRL. Plasma rico em plaquetas no rejuvenescimento cutâneo facial: uma revisão de literatura. Revista Uningá Review, 2017; 29(1): 227–236.
27. POPESCU MN, et al. Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control. BioMed Research International, 2021: 1–6.
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29. RAEISSADAT SA, et al. The Effect of Platelet-Rich Plasma on Pain, Function, and Quality of Life of Patients with Knee Osteoarthritis. Pain Research and Treatment, 2013; 1–7.
30. RAHIMZADEH P, et al. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clinical Interventions in Aging, 2018; 13: 73–79.
31. RAMPAL S, et al. A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis? Joint Diseases and Related Surgery, 2022; 33(1): 255–262.
32. RAYEGANI SM, et al. Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial. Orthopedic Reviews, 2014; 6(3).
33. SHEN L, et al. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. Journal of Orthopaedic Surgery and Research, 2017; 12(1): 16.
34. SILVA GA e LANGE ESN. Corporal image: The perception of the concept in obese female. Psicol. Argum., 2010; 28(60): 43–54.
35. TEY RV, et al. Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Comparative Analysis. Stem Cells International, 2022; 1–20.
36. USLU GÜVENDI E. Comparison of Efficiency Between Corticosteroid and Platelet Rich Plasma Injection Therapies in Patients With Knee Osteoarthritis. Archives of Rheumatology, 2019; 33(3): 273–281.
37. WU YT, et al. Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee Osteoarthritis. American Journal of Physical Medicine & Rehabilitation, 2018; 97(4): 248–254.
38. XU Z, et al. Efficacy of Platelet-Rich Plasma in Pain and Self-Report Function in Knee Osteoarthritis. American Journal of Physical Medicine & Rehabilitation, 2017; 96(11): 793–800.
2. ALMEIDA GPL, et al. Reliability, validity and responsiveness of the Step Up and Down (StUD) test for individuals with symptomatic knee osteoarthritis. Musculoskeletal Science and Practice, 2021; 56: 102454.
3. COGNASSE F, et al. The Non-Haemostatic Response of Platelets to Stress: An Actor of the Inflammatory Environment on Regenerative Medicine? Frontiers in Immunology, 2021; 12.
4. DELGADO D, et al. Current concepts in intraosseous Platelet-Rich Plasma injections for knee osteoarthritis. Journal of Clinical Orthopaedics and Trauma, 2019; 10(1): 36–41.
5. DUIF C, et al. Does intraoperative application of leukocyte-poor platelet-rich plasma during arthroscopy for knee degeneration affect postoperative pain, function and quality of life? A 12-month randomized controlled double-blind trial. Archives of Orthopaedic and Trauma Surgery, 2015; 135(7): 971–977.
6. FREIRE MR DE M, et al. Efeito comparativo entre a infiltração de plasma rico em plaquetas e o uso de corticosteroides no tratamento de osteoartrite do joelho: Estudo clínico prospectivo e randomizado. Revista Brasileira de Ortopedia, 2020; 55(05): 551–556.
7. GUILLIBERT C, et al. Single Injection of High Volume of Autologous Pure PRP Provides a Significant Improvement in Knee Osteoarthritis: A Prospective Routine Care Study. International Journal of Molecular Sciences, 2019; 20(6): 1327.
8. HART HF, et al. Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study. Rheumatology International, 2019.
9. HOSSEINI SA e PADHY RK. Body Image Distortion. 2022.
10. IIJIMA H, et al. Psychological health is associated with knee pain and physical function in patients with knee osteoarthritis: an exploratory cross-sectional study. BMC Psychology, 2018; 6(1): 19.
11. INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA. Projeções da População do Brasil e Unidades da Federação por sexo e idade: 2010-2060. Projeções de população por sexo e idade, 2018. Disponível em:
12. INSTITUTO PARANAENSE DE DESENVOLVIMENTO ECONÔMICO E SOCIAL (IPARDES). Caderno estatístico do Paraná. Instituto Paranaense de Desenvolvimento Econômico e Social, 2018.
13. KANCHANATAWAN W, et al. Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee. Knee Surgery, Sports Traumatology, Arthroscopy Springer Verlag, 2016.
14. KNOP E, et al. Plasma rico em plaquetas no tratamento da osteoartrite. Revista Brasileira de Reumatologia, 2016; 56(2): 152–164.
15. KON E, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: From early degeneration to osteoarthritis. Arthroscopy - Journal of Arthroscopic and Related Surgery, 2011; 27(11): 1490–1501.
16. KÜMPEL C, et al. Impact of a structured aquatic therapy program on patients with knee osteoarthritis. Acta Fisiátrica, 2016; 23(7): 361–387.
17. LAGUARDIA J, et al. Brazilian normative data for the Short Form 36 questionnaire, version 2. Revista Brasileira de Epidemiologia, 2013; 16(4): 889–897.
18. LI W, et al. The application of platelet-rich plasma in the treatment of knee osteoarthritis: A literature review. Journal of Orthopaedic Science, 2022; 27(2): 420–428.
19. MARTINEZ EZ. Bioestatística para os cursos de graduação da área da saúde: noções de métodos não paramétricos. São Paulo - SP, 2015.
20. MARTINI L, et al. Single Platelet-Rich Plasma Injection for Early Stage of Osteoarthritis of the Knee. Joints, 2017; 05(01): 002–006.
21. MARX FC, et al. Tradução e validação cultural do questionário algofuncional de Lequesne para osteoartrite de joelhos e quadris para a língua portuguesa. Revista Brasileira de Reumatologia, 2006; 46(4): 253–260.
22. MEHEUX CJ, et al. Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 2016; 32(3): 495–505.
23. MILLS K, et al. Current concepts in joint pain in knee osteoarthritis. Der Schmerz, 2019; 33(1): 22–29.
24. MUCHEDZI TA e ROBERTS SB. A systematic review of the effects of platelet rich plasma on outcomes for patients with knee osteoarthritis and following total knee arthroplasty. Surgeon, 2018; 16(4): 250–258.
25. PATEL S, et al. Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis. The American Journal of Sports Medicine, 2013; 41(2): 356–364.
26. PAVANI AA e FERNANDES TRL. Plasma rico em plaquetas no rejuvenescimento cutâneo facial: uma revisão de literatura. Revista Uningá Review, 2017; 29(1): 227–236.
27. POPESCU MN, et al. Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control. BioMed Research International, 2021: 1–6.
28. R DEVELOPMENT CORE TEAM. R: a language and environment for statistical computing. R Foundation for Statistical Computing, 2021.
29. RAEISSADAT SA, et al. The Effect of Platelet-Rich Plasma on Pain, Function, and Quality of Life of Patients with Knee Osteoarthritis. Pain Research and Treatment, 2013; 1–7.
30. RAHIMZADEH P, et al. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clinical Interventions in Aging, 2018; 13: 73–79.
31. RAMPAL S, et al. A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis? Joint Diseases and Related Surgery, 2022; 33(1): 255–262.
32. RAYEGANI SM, et al. Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial. Orthopedic Reviews, 2014; 6(3).
33. SHEN L, et al. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. Journal of Orthopaedic Surgery and Research, 2017; 12(1): 16.
34. SILVA GA e LANGE ESN. Corporal image: The perception of the concept in obese female. Psicol. Argum., 2010; 28(60): 43–54.
35. TEY RV, et al. Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Comparative Analysis. Stem Cells International, 2022; 1–20.
36. USLU GÜVENDI E. Comparison of Efficiency Between Corticosteroid and Platelet Rich Plasma Injection Therapies in Patients With Knee Osteoarthritis. Archives of Rheumatology, 2019; 33(3): 273–281.
37. WU YT, et al. Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee Osteoarthritis. American Journal of Physical Medicine & Rehabilitation, 2018; 97(4): 248–254.
38. XU Z, et al. Efficacy of Platelet-Rich Plasma in Pain and Self-Report Function in Knee Osteoarthritis. American Journal of Physical Medicine & Rehabilitation, 2017; 96(11): 793–800.