Principais alterações hematológicas e bioquímicas presentes em pacientes coinfectados com COVID-19 e dengue no Brasil
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Publicado
Aug 1, 2023
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Resumo
Objetivo: Descrever as principais alterações hematológicas e bioquímicas presentes em pacientes coinfectados com COVID-19 e dengue no Brasil através de uma revisão de literatura. Métodos: Foi realizada uma revisão integrativa a partir de artigos na base de dados Medical Literature Analysis and Retrieval System Online (MEDLINE via PUBMED). Foram utilizados artigos entre 2018 e 2022 e buscados os seguintes descritores: parâmetros laboratoriais, hematologia, bioquímica, dengue, COVID-19, coinfecção pela COVID-19 e dengue combinadas com Brasil. Resultados: Foram selecionados 34 artigos com o foco em descrever as principais características laboratoriais da dengue e da COVID-19 separadamente e em casos de coinfecção. Considerações finais: As principais alterações hematológicas e bioquímicas em pacientes com dengue são leucopenia, trombocitopenia e aumento do hematócrito, da ALT e da AST. Enquanto nos casos da COVID-19, os principais achados são leucopenia, linfopenia, aumento de D-dímero e ferritina. Porém, quando analisados casos de coinfecção, foi possível verificar características combinadas de ambas as doenças, como leucopenia, linfopenia, trombocitopenia e aumento de ALT, AST, D-dímero, ferritina e LDH. Contudo, novos achados como monocitopenia e aumento da glicemia também foram observados.
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Como Citar
SouzaB. L. dos S., SantosN. K. P. dos, AlmeidaC. L. F. de, & SantanaT. I. de. (2023). Principais alterações hematológicas e bioquímicas presentes em pacientes coinfectados com COVID-19 e dengue no Brasil. Revista Eletrônica Acervo Saúde, 23(7), e13179. https://doi.org/10.25248/reas.e13179.2023
Seção
Revisão Bibliográfica
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28. QUENTAL KN, et al. SARS-CoV-2 co-infection with dengue virus in Brazil: A potential case of viral transmission by a health care provider to household members. Travel Medicine and Infectious Disease, 2021; 40: 101975.
29. RAFI A, et al. Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. PLoS Neglected Tropical Diseases, 2020; 14(10): e0008567.
30. RAMOS JFO, et al. The Usefulness of Peripheral Blood Cell Counts to Distinguish COVID-19 from Dengue during Acute Infection. Tropical Medicine and Infectious Medicine, 2022; 7(2): 20.
31. ROSTAMI M e MANSOURITORGHABEH H. D-dimer level in COVID-19 infection: a systematic review, Expert Review of Hematology, 2020; 13(11): 1265-1275.
32. SALLES TS, et al. History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review. Parasites & vectors, 2018; 11(1): 1-12.
33. SALOMÃO R. Infectologia: Bases clínicas e tratamento / Reinaldo Salomão - 1. ed. - Rio de Janeiro: Guanabara Koogan, 2018; 644p.
34. SCHULTE HL, et al. SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil. BMC Infectious Diseases, 2021; 21(1): 1-8.
35. SOUSA DF, et al. Alterações hepáticas em decorrência da infecção pelo vírus da Dengue. Revista Científica Multidisciplinar Núcleo do Conhecimento, 2021; 2: 92-106.
36. SWAMY AM, et al. Liver function in dengue and its correlation with disease severity: a retrospective cross-sectional observational study in a tertiary care center in Coastal India. The Pan African Medical Journal, 2021; 40: 261.
37. TEOTÔNIO IMSN, et al. Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever. Acta tropica, 2021; 214: 105782.
38. TSHETEN T, et al. Clinical features and outcomes of COVID-19 and dengue co-infection: a systematic review. BMC infectious diseases, 2021; 21: 729.
39. YE L, et al. Prognostic value of liver biochemical parameters for COVID-19 mortality. Annals of hepatology, 2021; 21: 100279.
40. YUAN X, et al. Changes of hematological and immunological parameters in COVID-19 patients. International Journal of Hematology, 2020; 112(4): 553–559.
2. AL-SAMKARI H, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood, 2020; 136(4): 489-500.
3. BAIRWA M, et al. Hematological profile and biochemical markers of COVID-19 non-survivors: a retrospective analysis. Clinical Epidemiology and Global Health, 2021; 11: 100770.
4. BICUDO N, et al. Co-infection of SARS-CoV-2 and dengue virus: a clinical challenge. The Brazilian Journal of infectious diseases, 2020; 24(5): 452-454.
5. CHAO CH, et al. Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage. PLoS Pathogens, 2019; 15(4): e1007625.
6. CHENG Y, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney international, 2020; 97(5): 829-838.
7. CODO AC, et al. Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis-dependent axis. Cell metabolism, 2020; 32(3): 437-446.
8. CORREA R, et al. Dengue with hemorrhagic manifestations and acute pancreatitis: case report and review. Cureus, 2019; 11(6): e4895.
9. CUNHA MP, et al. Systemic dengue infection associated with a new dengue virus type 2 introduction in Brazil – a case report. BMC infectious diseases, 2021; 21: 311.
10. ERDINC B, et al. Hematological manifestations and complications of COVID-19. Advances in Clinical and Experimental Medicine, 2021: 30(1): 101-107.
11. ESTOFOLETE CF, et al. Presentation of fatal stroke due to SARS-CoV-2 and dengue virus coinfection. Journal of Medical Virology, 2021; 93(3): 1770-1775.
12. FARASANI A. Biochemical role of sérum ferratin and d-dimer parameters in COVID-19 diagnosis. Saudi Journal of Biological Sciences, 2021; 28(12): 7486-7490.
13. FARIDAH IN, et al. Dynamic changes of platelet and factors related dengue haemorrhagic ferver: a retrospective study in Indonesian. Diagnostics (Basel), 2022; 12(4): 950.
14. FURTADO ANR, et al. Dengue e seus avanços. Rev Brasil de Análises Clínicas, 2019; 51(3): 196-201.
15. HARAPAN H, et al. Dengue: a minireview. Víruses, 2020; 12(8): 829.
16. HEINEMANN M, et al. Case report: acute vision loss in a young returning traveler with dengue fever. The American Journal of Tropical Medicine and Hygiene, 2020; 103(5): 2026-2028.
17. HENRY BM, et al. Anormalidades de biomarcadores hematológicos, bioquímicos e imunológicos associados a doenças graves e mortalidade na doença de coronavírus 2019 (COVID-19): uma meta-análise. Clinical Chemistry and Laboratory Medicine (CCLM), 2020; 58(7): 1021-1028.
18. JAVADI A, et al. Changes of Routine Hematological Parameters in COVID-19 Patients: Correlation with Imaging Findings, RT-PCR and Outcome. Iranian Journal of Pathology, 2022; 17(1): 37-47.
19. JAYADAS TTP, et al. The clinical profile, hematological parameters and liver transaminases of dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka. BMC research notes, 2019; 12(1): 1-5.
20. KAMEDA K, et al. A testagem para COVID-19 no Brasil: esforços fragmentados e desafios para ampliar a capacidade diagnóstica no Sistema Único de Saúde. Cadernos de saúde pública, 2021; 37(3): e00277420.
21. KANTRI A, et al. Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco. Plos one, 2021; 16(2): e0246295.
22. KULARATNAM GAM, et al. Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study. BMC pediatrics, 2019; 19(1): 1-9.
23. KUO HJ, et al. Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: Emphasizing risk of severe dengue in the elderly. J of Microbiology, Immunology and Infection, 2018; 51(6): 740-748.
24. MAPALAGAMAGE M, et al. Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever? Disease Markers, 2018; 1-9.
25. MOHAN K, et al. Clinical profile and atypical manifestation of dengue fever cases between 2011 and 2018 in Chennai, India. Journal of Family Medicine and Primary Care, 2020; 9(2): 1119-1123.
26. NACHER M, et al. Simultaneous dengue and COVID-19 epidemics: Difficult days ahead? PLOS Neglected tropical disease, 2020; 14(8): e0008426.
27. PEREIRA SM, et al. Double Trouble: Dengue Followed by COVID-19 Infection Acquired in Two Different Regions: A Doctor's Case Report and Spatial Distribution of Cases in Presidente Prudente, São Paulo, Brazil. Tropical Medicine and Infectious Disease, 2021; 6(3): 156.
28. QUENTAL KN, et al. SARS-CoV-2 co-infection with dengue virus in Brazil: A potential case of viral transmission by a health care provider to household members. Travel Medicine and Infectious Disease, 2021; 40: 101975.
29. RAFI A, et al. Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients. PLoS Neglected Tropical Diseases, 2020; 14(10): e0008567.
30. RAMOS JFO, et al. The Usefulness of Peripheral Blood Cell Counts to Distinguish COVID-19 from Dengue during Acute Infection. Tropical Medicine and Infectious Medicine, 2022; 7(2): 20.
31. ROSTAMI M e MANSOURITORGHABEH H. D-dimer level in COVID-19 infection: a systematic review, Expert Review of Hematology, 2020; 13(11): 1265-1275.
32. SALLES TS, et al. History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review. Parasites & vectors, 2018; 11(1): 1-12.
33. SALOMÃO R. Infectologia: Bases clínicas e tratamento / Reinaldo Salomão - 1. ed. - Rio de Janeiro: Guanabara Koogan, 2018; 644p.
34. SCHULTE HL, et al. SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil. BMC Infectious Diseases, 2021; 21(1): 1-8.
35. SOUSA DF, et al. Alterações hepáticas em decorrência da infecção pelo vírus da Dengue. Revista Científica Multidisciplinar Núcleo do Conhecimento, 2021; 2: 92-106.
36. SWAMY AM, et al. Liver function in dengue and its correlation with disease severity: a retrospective cross-sectional observational study in a tertiary care center in Coastal India. The Pan African Medical Journal, 2021; 40: 261.
37. TEOTÔNIO IMSN, et al. Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever. Acta tropica, 2021; 214: 105782.
38. TSHETEN T, et al. Clinical features and outcomes of COVID-19 and dengue co-infection: a systematic review. BMC infectious diseases, 2021; 21: 729.
39. YE L, et al. Prognostic value of liver biochemical parameters for COVID-19 mortality. Annals of hepatology, 2021; 21: 100279.
40. YUAN X, et al. Changes of hematological and immunological parameters in COVID-19 patients. International Journal of Hematology, 2020; 112(4): 553–559.