Status of vitamin D: comparative study among individuals with autoimmune diseases and healthy
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Published
Dec 15, 2023
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Abstract
Objective: To compare vitamin D (VD) values between patients with and without the diagnosis of autoimmune disease, characterizing them according to sex, age, type of disease and level of VD. Methods: Cross-sectional study using data collected among January and August 2019, through medical records of patients over 18 years of age, of both sexes, who underwent serum calcidiol (25(OH)D) and classified with or without diagnosis of autoimmune disease. Data were analyzed using descriptive statistics, t-test, ANOVA and chi-square (p<0.005). Results: In both groups, among individuals in the groups according to the intervals proposed for vitamin evaluation. Regarding sex and age group, there was a predominance of females (90%) and the median age was 57 years. It was observed that rheumatoid arthritis is the autoimmune disease most related to low vitamin D values, followed by lupus erythematosus and multiple sclerosis. Conclusion: The prevalence of VD values below the recommendation for patients with autoimmune diseases found in this study underscores the need for assiduous monitoring and adequate supplementation for this group.
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SilvaA. L. da, de AndradeC. M. T., CorrêaG. B., PaivaG. C., LopesG. A., LimaJ. da S., CalilR. A. S., DiasA. M. N., MendesN. B. do E. S., & FrancoD. C. Z. (2023). Status of vitamin D: comparative study among individuals with autoimmune diseases and healthy. Electronic Journal Collection Health, 23(12), e14006. https://doi.org/10.25248/reas.e14006.2023
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References
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22. PLANTONE D, et al. Vitamin D in Neurological Diseases. International Journal of Molecular Science. 2023; 24(1): 87.
23. PRIETL B, et al. Vitamin D and Immune Function. Nutrients. 2013; 5: 2502-2521.
24. ROSA VD, et al. Nutricional control of immunity: Balancing the metabolic requirements with an appropriate imune function. Seminars in Immunology. 2015; 27(5): 300-309.
25. RUIZ-IRASTORZA G, et al. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology (Oxford). 2008; 47(6): 920-923.
26. SOCIEDADE BRASILEIRA DE ENDOCRINOLOGIA E METABOLOGIA (SBEM). Vitamina D: Novos valores de Referência. 2017. Disponível em: https://www.endocrino.org.br/vitamina-d-novos-valores-de-referencia/. Acessado em 04 de março de 2023.
27. SOCIEDADE BRASILEIRA DE REUMATOLOGIA. Vitamina D. 2022. Disponível em: https://www.reumatologia.org.br/site/wp-content/uploads/2021/05/Normas-Tec-Vitamina-D.pdf. Acessado em 04 de março de 2023.
28. SOUZA VA, et al. Associação de Hipovitaminose D com Lúpus Eritematoso Sistêmico e Inflamação. Jornal Brasileiro de Nefrologia. 2014; 36(4): 430-436.
29. TEIXEIRA TM e COSTA CL. Papel da vitamina D no lúpus eritematoso sistêmico Revista de Nutrição. 2012; 25(4): 531-538.
30. TSUJI M, et al. 1 alpha-hydroxyvitamin D3 inhibits type II collagen-induced arthritis in rats. FEBS Letters. 1994; 337(3): 248-250.
31. VASILEIOU ES, et al. Association of Vitamin D Polygenic Risk Scores and Disease Outcome in People With Multiple Sclerosis. Neurology, Neuroimmunology & Neuroinflammation. 2022; 10(1): e200062.
32. VIRGOLINO SFC, et al. Prevalência de hipovitaminose D em um grupo de pacientes com doenças autoimunes. Braspen Journal. 2017; 32(2): 160-164.
33. WANG X, et al. Low Serum Vitamin D Is Associated with Anti-Thyroid-Globulin Antibody in Female Individuals. International Journal Endocrinology. 2015; 2015: 285290.
34. ZHAO R, et al. Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease. Frontiers in Immunology. 2021; 12.
35. ZOU J, et al. Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease. Frontiers in Immunology. 2021; 11: 616483.
2. ANDJELKOVIC Z, et al. Disease modifying and immunomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients. Clinical and Experimental Rheumatology. 1999; 17(4): 453-456.
3. BORBA VZ, et al. Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporosis International. 2009; 20(3): 427-433.
4. BRUM D, et al. Supplementation and therapeutic use of vitamin D in patients with multiple sclerosis: Consensus of the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology. Arquivos de Neuro-Psiquiatria. 2014; 72(2): 152-156.
5. CASTRO LCGD. O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia & Metabologia. 2011; 55(8): 566-575.
6. CHAROENNGAM N e HOLICK MF. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. 2020; 12: 2097.
7. DUPUIS ML, et al. The role of vitamin D in autoimmune diseases: could sex make the difference? Biology of Sex Differences. 2021; 12(1): 12.
8. FARIAS AS, et al. Vitamin D3 induces IDO+ tolerogenic DCs and enhances Treg, reducing the severity of EAE. CNS Neuroscience & Therapeutics. 2013; 19(4): 269-277.
9. HAHN J, et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 2022; 376: e066452.
10. HARRISON SR, et al. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Calcified Tissue International. 2020; 106: 58-75.
11. HOLICK MF, et al. Avaliação, tratamento e prevenção da deficiência de vitamina D: uma diretriz de prática clínica da Endocrine Society. 2011; 96: 1911-1930.
12. KIM D. The Role of Vitamin D in Thyroid Diseases. Internacional Journal of Molecular Sciences. 2017; 18 (9): 1949.
13. KRATZ DB, et al. Deficiência de vitamina D (25OH) e seu impacto na qualidade de vida: uma revisão de literatura. Revista Brasileira de Análises Clínicas. 2018; 50(2): 118-23.
14. LEE YH e BAE SC. Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis. Clinical and Experimental Rheumatology. 2016; 34(5): 827-833.
15. MACEDO RM, et al. Lúpus Eritematoso Sistêmico: relação entre os diferentes tratamentos e evolução clínica. Revista de Medicina. 2020; 99(6): 573-580.
16. MARQUES CDL, et al. A importância dos níveis de vitamina D nas doenças autoimunes. Revista Brasileira de Reumatologia. 2010; 50(1): 67-80.
17. MINISTÉRIO DA SAÚDE. Protocolo Clínico e Diretrizes Terapêuticas da Artrite Reumatoide. 2020. Disponível em: https://www.gov.br/conitec/pt-br/midias/protocolos/20211112_portaria_conjunta_16_pcdt_ar.pdf. Acessado em: 4 de março de 2023.
18. MINISTÉRIO DA SAÚDE. Protocolo Clínico e Diretrizes Terapêuticas Esclerose Múltipla. 2019. Disponível em: https://www.gov.br/conitec/pt-br/midias/protocolos/20220201_portal_portaria_conjunta_1_pcdt_esclerose_multipla.pdf. Acessado em: 4 de março de 2023.
19. MINISTÉRIO DA SAÚDE. Protocolo Clínico e Diretrizes Terapêuticas do Lúpus Eritematoso Sistêmico. 2013. Disponível em: https://www.gov.br/conitec/pt-br/midias/protocolos/20221109_pcdt_lupus.pdf. Acessado em: 04 de março de 2023.
20. MUDARCA G, et al. Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications. Autoimmunity Reviews. 2019; 18(9): 102350.
21. PETRI M, et al. Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis & Rheumatology. 2013; 65 (7): 1865-1871.
22. PLANTONE D, et al. Vitamin D in Neurological Diseases. International Journal of Molecular Science. 2023; 24(1): 87.
23. PRIETL B, et al. Vitamin D and Immune Function. Nutrients. 2013; 5: 2502-2521.
24. ROSA VD, et al. Nutricional control of immunity: Balancing the metabolic requirements with an appropriate imune function. Seminars in Immunology. 2015; 27(5): 300-309.
25. RUIZ-IRASTORZA G, et al. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology (Oxford). 2008; 47(6): 920-923.
26. SOCIEDADE BRASILEIRA DE ENDOCRINOLOGIA E METABOLOGIA (SBEM). Vitamina D: Novos valores de Referência. 2017. Disponível em: https://www.endocrino.org.br/vitamina-d-novos-valores-de-referencia/. Acessado em 04 de março de 2023.
27. SOCIEDADE BRASILEIRA DE REUMATOLOGIA. Vitamina D. 2022. Disponível em: https://www.reumatologia.org.br/site/wp-content/uploads/2021/05/Normas-Tec-Vitamina-D.pdf. Acessado em 04 de março de 2023.
28. SOUZA VA, et al. Associação de Hipovitaminose D com Lúpus Eritematoso Sistêmico e Inflamação. Jornal Brasileiro de Nefrologia. 2014; 36(4): 430-436.
29. TEIXEIRA TM e COSTA CL. Papel da vitamina D no lúpus eritematoso sistêmico Revista de Nutrição. 2012; 25(4): 531-538.
30. TSUJI M, et al. 1 alpha-hydroxyvitamin D3 inhibits type II collagen-induced arthritis in rats. FEBS Letters. 1994; 337(3): 248-250.
31. VASILEIOU ES, et al. Association of Vitamin D Polygenic Risk Scores and Disease Outcome in People With Multiple Sclerosis. Neurology, Neuroimmunology & Neuroinflammation. 2022; 10(1): e200062.
32. VIRGOLINO SFC, et al. Prevalência de hipovitaminose D em um grupo de pacientes com doenças autoimunes. Braspen Journal. 2017; 32(2): 160-164.
33. WANG X, et al. Low Serum Vitamin D Is Associated with Anti-Thyroid-Globulin Antibody in Female Individuals. International Journal Endocrinology. 2015; 2015: 285290.
34. ZHAO R, et al. Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease. Frontiers in Immunology. 2021; 12.
35. ZOU J, et al. Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease. Frontiers in Immunology. 2021; 11: 616483.